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Social disorder, APOE-E4 genotype, and change in cognitive function among older adults living in Chicago

The goal of this paper is to describe the simultaneous influence of social and genetic risk factors on declines in cognitive functioning among older American adults. We use detailed information about the social characteristics of older adults' neighborhoods from the Chicago Health and Aging Project... Full description

Journal Title: Social Science & Medicine May 2012, Vol.74(10), pp.1584-1590
Main Author: Boardman, Jason D
Other Authors: Barnes, Lisa L , Wilson, Robert S , Evans, Denis A , de Leon, Carlos F. Mendes
Format: Electronic Article Electronic Article
Language: English
Subjects:
USA
ID: ISSN: 0277-9536 ; E-ISSN: 1873-5347 ; DOI: 10.1016/j.socscimed.2012.02.012
Link: https://www.sciencedirect.com/science/article/pii/S0277953612001827
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recordid: elsevier_sdoi_10_1016_j_socscimed_2012_02_012
title: Social disorder, APOE-E4 genotype, and change in cognitive function among older adults living in Chicago
format: Article
creator:
  • Boardman, Jason D
  • Barnes, Lisa L
  • Wilson, Robert S
  • Evans, Denis A
  • de Leon, Carlos F. Mendes
subjects:
  • Apoe4
  • Cognitive Decline
  • Neighborhoods
  • Gene-Environment Interaction
  • USA
  • Medicine
  • Social Sciences (General)
  • Public Health
ispartof: Social Science & Medicine, May 2012, Vol.74(10), pp.1584-1590
description: The goal of this paper is to describe the simultaneous influence of social and genetic risk factors on declines in cognitive functioning among older American adults. We use detailed information about the social characteristics of older adults' neighborhoods from the Chicago Health and Aging Project (  = 1655; ages 65+) in conjunction with information about respondent's APOE genotype to predict changes in cognitive function over time. Results indicate that the presence of the ɛ4 allele is associated with a significantly lower cognitive function score at baseline greater declines in cognitive function compared to those without this risk allele. Importantly, we also show significant variation in the effect of the ɛ4 allele across neighborhoods and our results indicate that this genotype is more strongly associated with cognitive function for residents of neighborhoods with the lowest levels of social disorder. Our findings support the non-causal...
language: eng
source:
identifier: ISSN: 0277-9536 ; E-ISSN: 1873-5347 ; DOI: 10.1016/j.socscimed.2012.02.012
fulltext: fulltext
issn:
  • 0277-9536
  • 02779536
  • 1873-5347
  • 18735347
url: Link


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titleSocial disorder, APOE-E4 genotype, and change in cognitive function among older adults living in Chicago
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subjectApoe4 ; Cognitive Decline ; Neighborhoods ; Gene-Environment Interaction ; USA ; Medicine ; Social Sciences (General) ; Public Health
descriptionThe goal of this paper is to describe the simultaneous influence of social and genetic risk factors on declines in cognitive functioning among older American adults. We use detailed information about the social characteristics of older adults' neighborhoods from the Chicago Health and Aging Project (  = 1655; ages 65+) in conjunction with information about respondent's APOE genotype to predict changes in cognitive function over time. Results indicate that the presence of the ɛ4 allele is associated with a significantly lower cognitive function score at baseline greater declines in cognitive function compared to those without this risk allele. Importantly, we also show significant variation in the effect of the ɛ4 allele across neighborhoods and our results indicate that this genotype is more strongly associated with cognitive function for residents of neighborhoods with the lowest levels of social disorder. Our findings support the non-causal...
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The goal of this paper is to describe the simultaneous influence of social and genetic risk factors on declines in cognitive functioning among older American adults. We use detailed information about the social characteristics of older adults' neighborhoods from the Chicago Health and Aging Project (

 = 1655; ages 65+) in conjunction with information about respondent's APOE genotype to predict changes in cognitive function over time. Results indicate that the presence of the ɛ4 allele is associated with a significantly lower cognitive function score at baseline

greater declines in cognitive function compared to those without this risk allele. Importantly, we also show significant variation in the effect of the ɛ4 allele across neighborhoods and our results indicate that this genotype is more strongly associated with cognitive function for residents of neighborhoods with the lowest levels of social disorder. Our findings support the non-causal...

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The goal of this paper is to describe the simultaneous influence of social and genetic risk factors on declines in cognitive functioning among older American adults. We use detailed information about the social characteristics of older adults' neighborhoods from the Chicago Health and Aging Project (

 = 1655; ages 65+) in conjunction with information about respondent's APOE genotype to predict changes in cognitive function over time. Results indicate that the presence of the ɛ4 allele is associated with a significantly lower cognitive function score at baseline

greater declines in cognitive function compared to those without this risk allele. Importantly, we also show significant variation in the effect of the ɛ4 allele across neighborhoods and our results indicate that this genotype is more strongly associated with cognitive function for residents of neighborhoods with the lowest levels of social disorder. Our findings support the non-causal...

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