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Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4

Three new cyclopentapeptides, versicoloritides A–C ( – ), a new orcinol tetramer, tetraorcinol A ( ), and two new lactones, versicolactones A and B ( and ) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated... Full description

Journal Title: Tetrahedron 2011, Vol.67(37), pp.7085-7089
Main Author: Zhuang, Yibin
Other Authors: Teng, Xiancun , Wang, Yi , Liu, Peipei , Wang, Hui , Li, Jing , Li, Guoqiang , Zhu, Weiming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0040-4020 ; E-ISSN: 1464-5416 ; DOI: 10.1016/j.tet.2011.07.003
Link: https://www.sciencedirect.com/science/article/pii/S0040402011010064
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recordid: elsevier_sdoi_10_1016_j_tet_2011_07_003
title: Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4
format: Article
creator:
  • Zhuang, Yibin
  • Teng, Xiancun
  • Wang, Yi
  • Liu, Peipei
  • Wang, Hui
  • Li, Jing
  • Li, Guoqiang
  • Zhu, Weiming
subjects:
  • Coral-Associated Fungus
  • Cyclopentapeptides
  • Polyketides
  • Aspergillus Versicolor
  • Cladiella Sp
  • Chemistry
ispartof: Tetrahedron, 2011, Vol.67(37), pp.7085-7089
description: Three new cyclopentapeptides, versicoloritides A–C ( – ), a new orcinol tetramer, tetraorcinol A ( ), and two new lactones, versicolactones A and B ( and ) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds – were evaluated for their radical-scavenging activity and antimicrobial activity against , , a , , , and and cytotoxicity against P388 and Hela cell lines. Compound showed weak radical-scavenging activity against the DPPH radical with an IC value of 67 μM.
language: eng
source:
identifier: ISSN: 0040-4020 ; E-ISSN: 1464-5416 ; DOI: 10.1016/j.tet.2011.07.003
fulltext: fulltext
issn:
  • 0040-4020
  • 00404020
  • 1464-5416
  • 14645416
url: Link


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titleCyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4
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descriptionThree new cyclopentapeptides, versicoloritides A–C ( – ), a new orcinol tetramer, tetraorcinol A ( ), and two new lactones, versicolactones A and B ( and ) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds – were evaluated for their radical-scavenging activity and antimicrobial activity against , , a , , , and and cytotoxicity against P388 and Hela cell lines. Compound showed weak radical-scavenging activity against the DPPH radical with an IC value of 67 μM.
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