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Engineering custom-designed osteochondral tissue grafts

Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disabilit... Full description

Journal Title: Trends in Biotechnology 2008, Vol.26(4), pp.181-189
Main Author: Grayson, Warren L
Other Authors: Chao, Pen-Hsiu Grace , Marolt, Darja , Kaplan, David L , Vunjak-Novakovic, Gordana
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0167-7799 ; E-ISSN: 1879-3096 ; DOI: 10.1016/j.tibtech.2007.12.009
Link: https://www.sciencedirect.com/science/article/pii/S0167779908000577
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recordid: elsevier_sdoi_10_1016_j_tibtech_2007_12_009
title: Engineering custom-designed osteochondral tissue grafts
format: Article
creator:
  • Grayson, Warren L
  • Chao, Pen-Hsiu Grace
  • Marolt, Darja
  • Kaplan, David L
  • Vunjak-Novakovic, Gordana
subjects:
  • Engineering
  • Chemistry
ispartof: Trends in Biotechnology, 2008, Vol.26(4), pp.181-189
description: Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).
language: eng
source:
identifier: ISSN: 0167-7799 ; E-ISSN: 1879-3096 ; DOI: 10.1016/j.tibtech.2007.12.009
fulltext: no_fulltext
issn:
  • 0167-7799
  • 01677799
  • 1879-3096
  • 18793096
url: Link


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titleEngineering custom-designed osteochondral tissue grafts
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descriptionTissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).
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Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).

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Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).

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