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A Bioprinted Liver-on-a-Chip for Drug Screening Applications

The need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in... Full description

Journal Title: Trends in Biotechnology September 2016, Vol.34(9), pp.681-682
Main Author: Knowlton, Stephanie
Other Authors: Tasoglu, Savas
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0167-7799 ; E-ISSN: 1879-3096 ; DOI: 10.1016/j.tibtech.2016.05.014
Link: https://www.sciencedirect.com/science/article/pii/S0167779916300609
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recordid: elsevier_sdoi_10_1016_j_tibtech_2016_05_014
title: A Bioprinted Liver-on-a-Chip for Drug Screening Applications
format: Article
creator:
  • Knowlton, Stephanie
  • Tasoglu, Savas
subjects:
  • Tissue Engineering
  • Bioprinting
  • 3d Cell Cultures
  • Liver Tissue Engineering
  • Organ-on-a-Chip
  • Microfluidics
  • Engineering
  • Chemistry
ispartof: Trends in Biotechnology, September 2016, Vol.34(9), pp.681-682
description: The need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in a hydrogel scaffold into a microfluidic device.
language: eng
source:
identifier: ISSN: 0167-7799 ; E-ISSN: 1879-3096 ; DOI: 10.1016/j.tibtech.2016.05.014
fulltext: no_fulltext
issn:
  • 0167-7799
  • 01677799
  • 1879-3096
  • 18793096
url: Link


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subjectTissue Engineering ; Bioprinting ; 3d Cell Cultures ; Liver Tissue Engineering ; Organ-on-a-Chip ; Microfluidics ; Engineering ; Chemistry
descriptionThe need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in a hydrogel scaffold into a microfluidic device.
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abstract

The need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in a hydrogel scaffold into a microfluidic device.

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lad01Trends in Biotechnology
date2016-09