schliessen

Filtern

 

Bibliotheken

Adipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft

Adipose-derived mesenchymal stem cells (ADSCs) possess a liver regeneration capacity and immunosuppressive activity and hold promise in autologous cell-based technology. This study aimed to determine whether autologous ADSCs can improve outcomes in the rat reduced size liver transplantation model. A... Full description

Journal Title: Transplant Immunology December 2017, Vol.45, pp.1-7
Main Author: Gao, Wei
Other Authors: Zhang, Luzhou , Zhang, Yanyan , Sun, Chao , Chen, Xiaobo , Wang, Yuliang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0966-3274 ; E-ISSN: 1878-5492 ; DOI: 10.1016/j.trim.2017.07.005
Link: http://dx.doi.org/10.1016/j.trim.2017.07.005
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_trim_2017_07_005
title: Adipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft
format: Article
creator:
  • Gao, Wei
  • Zhang, Luzhou
  • Zhang, Yanyan
  • Sun, Chao
  • Chen, Xiaobo
  • Wang, Yuliang
subjects:
  • Adipose-Derived Mesenchymal Stem Cells
  • Reduced Size Liver Transplantation
  • Liver Regeneration
  • Acute Rejection
  • Adipose-Derived Mesenchymal Stem Cells
  • Reduced Size Liver Transplantation
  • Liver Regeneration
  • Acute Rejection
  • Medicine
  • Biology
ispartof: Transplant Immunology, December 2017, Vol.45, pp.1-7
description: Adipose-derived mesenchymal stem cells (ADSCs) possess a liver regeneration capacity and immunosuppressive activity and hold promise in autologous cell-based technology. This study aimed to determine whether autologous ADSCs can improve outcomes in the rat reduced size liver transplantation model. Allogeneic 50% orthotopic liver transplantation followed by administration of autologous ADSCs delivered into the portal vein system was conducted in LEW donor rats and BN recipient rats with phosphate buffered solution (PBS) infusion used as the control. Liver grafts and recipient serum were obtained. We assessed histopathology, regeneration, apoptosis, serum liver enzymes, serum cytokines, and circulating regulatory T cells (Tregs) on postoperative day (POD) 7 and 14. It was found that ADSCs significantly reduced acute rejection and improved the allograft's survival times (median, 24days). Liver function, as assessed by the levels of alanine aminotransferase, aspartate aminotransferase,...
language: eng
source:
identifier: ISSN: 0966-3274 ; E-ISSN: 1878-5492 ; DOI: 10.1016/j.trim.2017.07.005
fulltext: fulltext
issn:
  • 0966-3274
  • 09663274
  • 1878-5492
  • 18785492
url: Link


@attributes
ID1926249054
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_trim_2017_07_005
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_trim_2017_07_005
sourcesystemPC
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
13AAAJQ
14AAEDT
15AAKOC
16AAOAW
17AAQFI
18AARKO
19ABBQC
20ABLVK
21ABMZM
22ABYKQ
23ACDAQ
24ACIUM
25ACRLP
26ADALY
27AEKER
28AEVXI
29AFKWA
30AFTJW
31AFXIZ
32AGEKW
33AGHFR
34AGUBO
35AGYEJ
36AHHHB
37AIKHN
38AITUG
39AJBFU
40AJOXV
41AJRQY
42AJUYK
43AMFUW
44AMRAJ
45ANZVX
46BLXMC
47BNPGV
48CJTIS
49EO8
50EO9
51EP2
52EP3
53FDB
54FGOYB
55FIRID
56FNPLU
57G-Q
58GBLVA
59HDU
60HMG
61HMK
62HMO
63J1W
64KOM
65LCYCR
66LUGTX
67O9~
68OAUVE
69OK0
70P-8
71P-9
72PC.
73Q38
74R2-
75RPZ
76SAE
77SDF
78SDG
79SES
80SEW
81SIN
82SSH
83SSI
84SSZ
85T5K
86Z5R
87~G-
pqid1926687434
galeid523041213
display
typearticle
titleAdipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft
creatorGao, Wei ; Zhang, Luzhou ; Zhang, Yanyan ; Sun, Chao ; Chen, Xiaobo ; Wang, Yuliang
ispartofTransplant Immunology, December 2017, Vol.45, pp.1-7
identifier
subjectAdipose-Derived Mesenchymal Stem Cells ; Reduced Size Liver Transplantation ; Liver Regeneration ; Acute Rejection ; Adipose-Derived Mesenchymal Stem Cells ; Reduced Size Liver Transplantation ; Liver Regeneration ; Acute Rejection ; Medicine ; Biology
descriptionAdipose-derived mesenchymal stem cells (ADSCs) possess a liver regeneration capacity and immunosuppressive activity and hold promise in autologous cell-based technology. This study aimed to determine whether autologous ADSCs can improve outcomes in the rat reduced size liver transplantation model. Allogeneic 50% orthotopic liver transplantation followed by administration of autologous ADSCs delivered into the portal vein system was conducted in LEW donor rats and BN recipient rats with phosphate buffered solution (PBS) infusion used as the control. Liver grafts and recipient serum were obtained. We assessed histopathology, regeneration, apoptosis, serum liver enzymes, serum cytokines, and circulating regulatory T cells (Tregs) on postoperative day (POD) 7 and 14. It was found that ADSCs significantly reduced acute rejection and improved the allograft's survival times (median, 24days). Liver function, as assessed by the levels of alanine aminotransferase, aspartate aminotransferase,...
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1016/j.trim.2017.07.005$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Gao, Wei
1Zhang, Luzhou
2Zhang, Yanyan
3Sun, Chao
4Chen, Xiaobo
5Wang, Yuliang
titleAdipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft
description

Adipose-derived mesenchymal stem cells (ADSCs) possess a liver regeneration capacity and immunosuppressive activity and hold promise in autologous cell-based technology. This study aimed to determine whether autologous ADSCs can improve outcomes in the rat reduced size liver transplantation model. Allogeneic 50% orthotopic liver transplantation followed by administration of autologous ADSCs delivered into the portal vein system was conducted in LEW donor rats and BN recipient rats with phosphate buffered solution (PBS) infusion used as the control. Liver grafts and recipient serum were obtained. We assessed histopathology, regeneration, apoptosis, serum liver enzymes, serum cytokines, and circulating regulatory T cells (Tregs) on postoperative day (POD) 7 and 14. It was found that ADSCs significantly reduced acute rejection and improved the allograft's survival times (median, 24days). Liver function, as assessed by the levels of alanine aminotransferase, aspartate aminotransferase,...

subject
0Adipose-Derived Mesenchymal Stem Cells
1Reduced Size Liver Transplantation
2Liver Regeneration
3Acute Rejection
4Medicine
5Biology
general
0English
1Elsevier B.V
210.1016/j.trim.2017.07.005
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_trim_2017_07_005
issn
00966-3274
109663274
21878-5492
318785492
rsrctypearticle
creationdate2017
addtitleTransplant Immunology
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
13AAAJQ
14AAEDT
15AAKOC
16AAOAW
17AAQFI
18AARKO
19ABBQC
20ABLVK
21ABMZM
22ABYKQ
23ACDAQ
24ACIUM
25ACRLP
26ADALY
27AEKER
28AEVXI
29AFKWA
30AFTJW
31AFXIZ
32AGEKW
33AGHFR
34AGUBO
35AGYEJ
36AHHHB
37AIKHN
38AITUG
39AJBFU
40AJOXV
41AJRQY
42AJUYK
43AMFUW
44AMRAJ
45ANZVX
46BLXMC
47BNPGV
48CJTIS
49EO8
50EO9
51EP2
52EP3
53FDB
54FGOYB
55FIRID
56FNPLU
57G-Q
58GBLVA
59HDU
60HMG
61HMK
62HMO
63J1W
64KOM
65LCYCR
66LUGTX
67O9~
68OAUVE
69OK0
70P-8
71P-9
72PC.
73Q38
74R2-
75RPZ
76SAE
77SDF
78SDG
79SES
80SEW
81SIN
82SSH
83SSI
84SSZ
85T5K
86Z5R
87~G-
startdate20171201
enddate20171231
lsr40Transplant Immunology, December 2017, Vol.45, pp.1-7
doi10.1016/j.trim.2017.07.005
citationpf 1 pt 7 vol 45
lsr30VSR-Enriched:[pqid, galeid]
sort
titleAdipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft
authorGao, Wei ; Zhang, Luzhou ; Zhang, Yanyan ; Sun, Chao ; Chen, Xiaobo ; Wang, Yuliang
creationdate20171200
lso0120171200
facets
frbrgroupid8237994008857328438
frbrtype5
newrecords20190904
languageeng
topic
0Adipose-Derived Mesenchymal Stem Cells
1Reduced Size Liver Transplantation
2Liver Regeneration
3Acute Rejection
4Medicine
5Biology
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Gao, Wei
1Zhang, Luzhou
2Zhang, Yanyan
3Sun, Chao
4Chen, Xiaobo
5Wang, Yuliang
jtitleTransplant Immunology
creationdate2017
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Gao
1Zhang
2Sun
3Chen
4Wang
aufirst
0Wei
1Luzhou
2Yanyan
3Chao
4Xiaobo
5Yuliang
auinitW
auinit1W
au
0Gao, Wei
1Zhang, Luzhou
2Zhang, Yanyan
3Sun, Chao
4Chen, Xiaobo
5Wang, Yuliang
atitleAdipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft
jtitleTransplant Immunology
risdate201712
volume45
spage1
epage7
pages1-7
issn0966-3274
eissn1878-5492
formatjournal
genrearticle
ristypeJOUR
abstract

Adipose-derived mesenchymal stem cells (ADSCs) possess a liver regeneration capacity and immunosuppressive activity and hold promise in autologous cell-based technology. This study aimed to determine whether autologous ADSCs can improve outcomes in the rat reduced size liver transplantation model. Allogeneic 50% orthotopic liver transplantation followed by administration of autologous ADSCs delivered into the portal vein system was conducted in LEW donor rats and BN recipient rats with phosphate buffered solution (PBS) infusion used as the control. Liver grafts and recipient serum were obtained. We assessed histopathology, regeneration, apoptosis, serum liver enzymes, serum cytokines, and circulating regulatory T cells (Tregs) on postoperative day (POD) 7 and 14. It was found that ADSCs significantly reduced acute rejection and improved the allograft's survival times (median, 24days). Liver function, as assessed by the levels of alanine aminotransferase, aspartate aminotransferase,...

pubElsevier B.V
doi10.1016/j.trim.2017.07.005
lad01Transplant Immunology
date2017-12