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Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs

The pharmacokinetics of dexamethasone (DEX) were investigated after an intravenous (IV) or intramuscular (IM) bolus injection of 0.3 mg/kg bodyweight DEX sodium phosphate in pigs. The plasma concentrations of DEX were determined using a validated high-performance liquid chromatography–tandem mass sp... Full description

Journal Title: The Veterinary Journal October 2013, Vol.198(1), pp.286-288
Main Author: Wyns, Heidi
Other Authors: Meyer, Evelyne , Watteyn, Anneleen , Plessers, Elke , De Baere, Siegrid , De Backer, Patrick , Croubels, Siska
Format: Electronic Article Electronic Article
Language: English
Subjects:
Pig
ID: ISSN: 1090-0233 ; E-ISSN: 1532-2971 ; DOI: 10.1016/j.tvjl.2013.06.015
Link: https://www.sciencedirect.com/science/article/pii/S1090023313002992
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recordid: elsevier_sdoi_10_1016_j_tvjl_2013_06_015
title: Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs
format: Article
creator:
  • Wyns, Heidi
  • Meyer, Evelyne
  • Watteyn, Anneleen
  • Plessers, Elke
  • De Baere, Siegrid
  • De Backer, Patrick
  • Croubels, Siska
subjects:
  • Dexamethasone
  • Pharmacokinetics
  • Pig
  • Bioavailability
  • Intramuscular
  • Veterinary Medicine
ispartof: The Veterinary Journal, October 2013, Vol.198(1), pp.286-288
description: The pharmacokinetics of dexamethasone (DEX) were investigated after an intravenous (IV) or intramuscular (IM) bolus injection of 0.3 mg/kg bodyweight DEX sodium phosphate in pigs. The plasma concentrations of DEX were determined using a validated high-performance liquid chromatography–tandem mass spectrometry (LC–MS/MS) method and the pharmacokinetics were determined by one-compartmental analysis. The mean area under the plasma concentration–time curve and the mean elimination half-life were 133.07 ± 39.59 ng.h/mL and 0.77 h, and 173.24 ± 53.59 ng h/mL and 1.06 h following IV and IM administration, respectively. The volume of distribution and clearance recorded after IV administration were 2.78 ± 0.88 L/kg and 2.39...
language: eng
source:
identifier: ISSN: 1090-0233 ; E-ISSN: 1532-2971 ; DOI: 10.1016/j.tvjl.2013.06.015
fulltext: fulltext
issn:
  • 1090-0233
  • 10900233
  • 1532-2971
  • 15322971
url: Link


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subjectDexamethasone ; Pharmacokinetics ; Pig ; Bioavailability ; Intramuscular ; Veterinary Medicine
descriptionThe pharmacokinetics of dexamethasone (DEX) were investigated after an intravenous (IV) or intramuscular (IM) bolus injection of 0.3 mg/kg bodyweight DEX sodium phosphate in pigs. The plasma concentrations of DEX were determined using a validated high-performance liquid chromatography–tandem mass spectrometry (LC–MS/MS) method and the pharmacokinetics were determined by one-compartmental analysis. The mean area under the plasma concentration–time curve and the mean elimination half-life were 133.07 ± 39.59 ng.h/mL and 0.77 h, and 173.24 ± 53.59 ng h/mL and 1.06 h following IV and IM administration, respectively. The volume of distribution and clearance recorded after IV administration were 2.78 ± 0.88 L/kg and 2.39...
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