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Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene

DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cel... Full description

Journal Title: Vaccine 2007, Vol.25(32), pp.6118-6128
Main Author: Register, Karen B
Other Authors: Sacco, Randy E , Brockmeier, Susan L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2007.05.028
Link: http://dx.doi.org/10.1016/j.vaccine.2007.05.028
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recordid: elsevier_sdoi_10_1016_j_vaccine_2007_05_028
title: Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene
format: Article
creator:
  • Register, Karen B
  • Sacco, Randy E
  • Brockmeier, Susan L
subjects:
  • Pasteurella Multocida
  • Toxin
  • DNA Vaccine
  • Pasteurella Multocida
  • Toxin
  • DNA Vaccine
  • Medicine
  • Biology
  • Veterinary Medicine
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: Vaccine, 2007, Vol.25(32), pp.6118-6128
description: DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-γ following immunization of mice were achieved with pMM4, the construct containing a signal sequence and encoding the entire toxin. Antibody responses were also induced in pigs immunized with pMM4 and levels increased significantly following booster injections and experimental infection with P. multocida. Significantly increased expression of interferon-γ was detected in only a small subset of pMM4-immunized pigs. This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine.
language: eng
source:
identifier: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2007.05.028
fulltext: fulltext
issn:
  • 0264-410X
  • 0264410X
  • 1873-2518
  • 18732518
url: Link


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titleImmune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene
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identifier
subjectPasteurella Multocida ; Toxin ; DNA Vaccine ; Pasteurella Multocida ; Toxin ; DNA Vaccine ; Medicine ; Biology ; Veterinary Medicine ; Pharmacy, Therapeutics, & Pharmacology
descriptionDNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-γ following immunization of mice were achieved with pMM4, the construct containing a signal sequence and encoding the entire toxin. Antibody responses were also induced in pigs immunized with pMM4 and levels increased significantly following booster injections and experimental infection with P. multocida. Significantly increased expression of interferon-γ was detected in only a small subset of pMM4-immunized pigs. This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine.
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DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-γ following immunization of mice were achieved with pMM4, the construct containing a signal sequence and encoding the entire toxin. Antibody responses were also induced in pigs immunized with pMM4 and levels increased significantly following booster injections and experimental infection with P. multocida. Significantly increased expression of interferon-γ was detected in only a small subset of pMM4-immunized pigs. This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine.

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