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Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene

Abstract DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and s... Full description

Journal Title: Vaccine 2007, Vol.25 (32), p.6118-6128
Main Author: Register, Karen B
Other Authors: Sacco, Randy E , Brockmeier, Susan L
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Quelle: Alma/SFX Local Collection
Publisher: Oxford: Elsevier Ltd
ID: ISSN: 0264-410X
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recordid: cdi_proquest_miscellaneous_70731235
title: Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene
format: Article
creator:
  • Register, Karen B
  • Sacco, Randy E
  • Brockmeier, Susan L
subjects:
  • Allergy and Immunology
  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins - genetics
  • Bacterial Proteins - immunology
  • Bacterial Toxins - genetics
  • Bacterial Toxins - immunology
  • Bacterial Vaccines - adverse effects
  • Bacterial Vaccines - genetics
  • Bacterial Vaccines - immunology
  • Bacteriology
  • Biological and medical sciences
  • Biological response modifiers
  • Bordetella bronchiseptica - isolation & purification
  • Bordetella Infections - microbiology
  • DNA
  • DNA vaccine
  • DNA, Bacterial - genetics
  • Fundamental and applied biological sciences. Psychology
  • Genetic research
  • Mice
  • Microbiology
  • Miscellaneous
  • Molecular Sequence Data
  • Nose - microbiology
  • Pasteurella Infections - immunology
  • Pasteurella Infections - prevention & control
  • Pasteurella Infections - veterinary
  • Pasteurella multocida
  • Pasteurella multocida - genetics
  • Pasteurella multocida - immunology
  • Swine
  • Swine - immunology
  • Toxin
  • Vaccines
  • Vaccines, DNA - adverse effects
  • Vaccines, DNA - genetics
  • Vaccines, DNA - immunology
ispartof: Vaccine, 2007, Vol.25 (32), p.6118-6128
description: Abstract DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-γ following immunization of mice were achieved with pMM4, the construct containing a signal sequence and encoding the entire toxin. Antibody responses were also induced in pigs immunized with pMM4 and levels increased significantly following booster injections and experimental infection with P. multocida . Significantly increased expression of interferon-γ was detected in only a small subset of pMM4-immunized pigs. This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionAbstract DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-γ following immunization of mice were achieved with pMM4, the construct containing a signal sequence and encoding the entire toxin. Antibody responses were also induced in pigs immunized with pMM4 and levels increased significantly following booster injections and experimental infection with P. multocida . Significantly increased expression of interferon-γ was detected in only a small subset of pMM4-immunized pigs. This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine.
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languageeng
publisherOxford: Elsevier Ltd
subjectAllergy and Immunology ; Amino Acid Sequence ; Animals ; Bacterial Proteins - genetics ; Bacterial Proteins - immunology ; Bacterial Toxins - genetics ; Bacterial Toxins - immunology ; Bacterial Vaccines - adverse effects ; Bacterial Vaccines - genetics ; Bacterial Vaccines - immunology ; Bacteriology ; Biological and medical sciences ; Biological response modifiers ; Bordetella bronchiseptica - isolation & purification ; Bordetella Infections - microbiology ; DNA ; DNA vaccine ; DNA, Bacterial - genetics ; Fundamental and applied biological sciences. Psychology ; Genetic research ; Mice ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Nose - microbiology ; Pasteurella Infections - immunology ; Pasteurella Infections - prevention & control ; Pasteurella Infections - veterinary ; Pasteurella multocida ; Pasteurella multocida - genetics ; Pasteurella multocida - immunology ; Swine ; Swine - immunology ; Toxin ; Vaccines ; Vaccines, DNA - adverse effects ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology
ispartofVaccine, 2007, Vol.25 (32), p.6118-6128
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3Bacterial Proteins - genetics
4Bacterial Proteins - immunology
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7Bacterial Vaccines - adverse effects
8Bacterial Vaccines - genetics
9Bacterial Vaccines - immunology
10Bacteriology
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12Biological response modifiers
13Bordetella bronchiseptica - isolation & purification
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16DNA vaccine
17DNA, Bacterial - genetics
18Fundamental and applied biological sciences. Psychology
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20Mice
21Microbiology
22Miscellaneous
23Molecular Sequence Data
24Nose - microbiology
25Pasteurella Infections - immunology
26Pasteurella Infections - prevention & control
27Pasteurella Infections - veterinary
28Pasteurella multocida
29Pasteurella multocida - genetics
30Pasteurella multocida - immunology
31Swine
32Swine - immunology
33Toxin
34Vaccines
35Vaccines, DNA - adverse effects
36Vaccines, DNA - genetics
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abstractAbstract DNA vaccines were constructed with either a 5′-truncated or full-length, genetically detoxified toxin gene from Pasteurella multocida and two different DNA vaccine vectors, distinguished by the presence or absence of a secretion signal sequence. Optimal PMT-specific antibody responses and spleen cell secretion of interferon-γ following immunization of mice were achieved with pMM4, the construct containing a signal sequence and encoding the entire toxin. Antibody responses were also induced in pigs immunized with pMM4 and levels increased significantly following booster injections and experimental infection with P. multocida . Significantly increased expression of interferon-γ was detected in only a small subset of pMM4-immunized pigs. This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine.
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