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Highly effective generic adjuvant systems for orphan or poverty-related vaccines

Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold... Full description

Journal Title: Vaccine 29 January 2011, Vol.29(5), pp.873-877
Main Author: Rao, Mangala
Other Authors: Peachman, Kristina K , Li, Qin , Matyas, Gary R , Shivachandra, Sathish B , Borschel, Richard , Morthole, Venee I , Fernandez-Prada, Carmen , Alving, Carl R , Rao, Venigalla B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2010.11.049
Link: https://www.sciencedirect.com/science/article/pii/S0264410X1001683X
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recordid: elsevier_sdoi_10_1016_j_vaccine_2010_11_049
title: Highly effective generic adjuvant systems for orphan or poverty-related vaccines
format: Article
creator:
  • Rao, Mangala
  • Peachman, Kristina K
  • Li, Qin
  • Matyas, Gary R
  • Shivachandra, Sathish B
  • Borschel, Richard
  • Morthole, Venee I
  • Fernandez-Prada, Carmen
  • Alving, Carl R
  • Rao, Venigalla B
subjects:
  • Adjuvants
  • Liposomes
  • Monophosphoryl Lipid A
  • Bacteriophage T4
  • Anthrax
  • Non-Human Primates
  • Medicine
  • Biology
  • Veterinary Medicine
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: Vaccine, 29 January 2011, Vol.29(5), pp.873-877
description: Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
language: eng
source:
identifier: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2010.11.049
fulltext: fulltext
issn:
  • 0264-410X
  • 0264410X
  • 1873-2518
  • 18732518
url: Link


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titleHighly effective generic adjuvant systems for orphan or poverty-related vaccines
creatorRao, Mangala ; Peachman, Kristina K ; Li, Qin ; Matyas, Gary R ; Shivachandra, Sathish B ; Borschel, Richard ; Morthole, Venee I ; Fernandez-Prada, Carmen ; Alving, Carl R ; Rao, Venigalla B
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subjectAdjuvants ; Liposomes ; Monophosphoryl Lipid A ; Bacteriophage T4 ; Anthrax ; Non-Human Primates ; Medicine ; Biology ; Veterinary Medicine ; Pharmacy, Therapeutics, & Pharmacology
descriptionSafe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
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Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.

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Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.

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