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Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs

In order to create an effective immunization approach for a potential vaccine to heroin, liposomes containing monophosphoryl lipid A [L(MPLA)] were tested as an adjuvant system to induce antibodies to heroin hapten analogs. Four synthetic haptens and two immunization strategies were employed. In the... Full description

Journal Title: Vaccine 10 June 2013, Vol.31(26), pp.2804-2810
Main Author: Matyas, Gary R
Other Authors: Mayorov, Alexander V , Rice, Kenner C , Jacobson, Arthur E , Cheng, Kejun , Iyer, Malliga R , Li, Fuying , Beck, Zoltan , Janda, Kim D , Alving, Carl R
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2013.04.027
Link: https://www.sciencedirect.com/science/article/pii/S0264410X13004660
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recordid: elsevier_sdoi_10_1016_j_vaccine_2013_04_027
title: Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs
format: Article
creator:
  • Matyas, Gary R
  • Mayorov, Alexander V
  • Rice, Kenner C
  • Jacobson, Arthur E
  • Cheng, Kejun
  • Iyer, Malliga R
  • Li, Fuying
  • Beck, Zoltan
  • Janda, Kim D
  • Alving, Carl R
subjects:
  • Liposomes Containing Monophosphoryl Lipid A
  • Adjuvant System
  • Opiate Vaccine
  • Antibodies to Heroin Haptens
  • Medicine
  • Biology
  • Veterinary Medicine
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: Vaccine, 10 June 2013, Vol.31(26), pp.2804-2810
description: In order to create an effective immunization approach for a potential vaccine to heroin, liposomes containing monophosphoryl lipid A [L(MPLA)] were tested as an adjuvant system to induce antibodies to heroin hapten analogs. Four synthetic haptens and two immunization strategies were employed. In the strategy, a hydrophobic 23 amino acid immunogenic peptide derived from the membrane proximal external region of gp41 from HIV-1 envelope protein was embedded as a carrier in the outer surface of L(MPLA), to which was conjugated a 15 amino acid universal T cell epitope and a terminal heroin hapten analog. In the strategy, tetanus toxoid (TT) carrier protein was decorated with haptens by conjugation, and the hapten-conjugated protein was mixed with L(MPLA). After immunization of mice, each of the immunization strategies was effective for induction of IgG anti-hapten antibodies. The immunization strategy induced a mean end-point...
language: eng
source:
identifier: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2013.04.027
fulltext: fulltext
issn:
  • 0264-410X
  • 0264410X
  • 1873-2518
  • 18732518
url: Link


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titleLiposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs
creatorMatyas, Gary R ; Mayorov, Alexander V ; Rice, Kenner C ; Jacobson, Arthur E ; Cheng, Kejun ; Iyer, Malliga R ; Li, Fuying ; Beck, Zoltan ; Janda, Kim D ; Alving, Carl R
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subjectLiposomes Containing Monophosphoryl Lipid A ; Adjuvant System ; Opiate Vaccine ; Antibodies to Heroin Haptens ; Medicine ; Biology ; Veterinary Medicine ; Pharmacy, Therapeutics, & Pharmacology
descriptionIn order to create an effective immunization approach for a potential vaccine to heroin, liposomes containing monophosphoryl lipid A [L(MPLA)] were tested as an adjuvant system to induce antibodies to heroin hapten analogs. Four synthetic haptens and two immunization strategies were employed. In the strategy, a hydrophobic 23 amino acid immunogenic peptide derived from the membrane proximal external region of gp41 from HIV-1 envelope protein was embedded as a carrier in the outer surface of L(MPLA), to which was conjugated a 15 amino acid universal T cell epitope and a terminal heroin hapten analog. In the strategy, tetanus toxoid (TT) carrier protein was decorated with haptens by conjugation, and the hapten-conjugated protein was mixed with L(MPLA). After immunization of mice, each of the immunization strategies was effective for induction of IgG anti-hapten antibodies. The immunization strategy induced a mean end-point...
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