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Efficacy of Type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs

•Chinese HP-PRRSV JXwn06 isolate induced severe disease in 10-week-old pigs.•Vietnamese HP-PRRSV SRV07 isolate was less severe.•Attenuated Type 2 PRRSV vaccine induced protection against HP-PRRSV challenge.•Vaccine protection was not sterilizing immunity. Porcine reproductive and respiratory syndrom... Full description

Journal Title: Vaccine 12 November 2014, Vol.32(48), pp.6457-6462
Main Author: Lager, Kelly M
Other Authors: Schlink, Sarah N , Brockmeier, Susan L , Miller, Laura C , Henningson, Jamie N , Kappes, Matthew A , Kehrli, Marcus E , Loving, Crystal L , Guo, Baoquing , Swenson, Sabrina L , Yang, Han-Chun , Faaberg, Kay S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2014.09.046
Link: http://dx.doi.org/10.1016/j.vaccine.2014.09.046
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recordid: elsevier_sdoi_10_1016_j_vaccine_2014_09_046
title: Efficacy of Type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs
format: Article
creator:
  • Lager, Kelly M
  • Schlink, Sarah N
  • Brockmeier, Susan L
  • Miller, Laura C
  • Henningson, Jamie N
  • Kappes, Matthew A
  • Kehrli, Marcus E
  • Loving, Crystal L
  • Guo, Baoquing
  • Swenson, Sabrina L
  • Yang, Han-Chun
  • Faaberg, Kay S
subjects:
  • Hp-Prrsv
  • Swine
  • Prrsv Vaccine
  • Hp-Prrsv
  • Swine
  • Prrsv Vaccine
  • Medicine
  • Biology
  • Veterinary Medicine
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: Vaccine, 12 November 2014, Vol.32(48), pp.6457-6462
description: •Chinese HP-PRRSV JXwn06 isolate induced severe disease in 10-week-old pigs.•Vietnamese HP-PRRSV SRV07 isolate was less severe.•Attenuated Type 2 PRRSV vaccine induced protection against HP-PRRSV challenge.•Vaccine protection was not sterilizing immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant reproductive losses in the sow herd and respiratory disease in growing pigs. The virus belongs to the family Arteriviridae and there are two major genotypes. Type 1 is represented by Lelystad virus, the European prototype virus, and Type 2 is represented by the North American prototype virus, VR-2332. Depending on husbandry, immune status of the herd, and virulence of the isolate, the severity of disease and magnitude of economic loss can be variable. Vaccine use is not always successful indicating a lack of cross-protection between vaccine strains and circulating wild-type viruses. To date, there is no clear method to demonstrate...
language: eng
source:
identifier: ISSN: 0264-410X ; E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2014.09.046
fulltext: fulltext
issn:
  • 0264-410X
  • 0264410X
  • 1873-2518
  • 18732518
url: Link


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titleEfficacy of Type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs
creatorLager, Kelly M ; Schlink, Sarah N ; Brockmeier, Susan L ; Miller, Laura C ; Henningson, Jamie N ; Kappes, Matthew A ; Kehrli, Marcus E ; Loving, Crystal L ; Guo, Baoquing ; Swenson, Sabrina L ; Yang, Han-Chun ; Faaberg, Kay S
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description•Chinese HP-PRRSV JXwn06 isolate induced severe disease in 10-week-old pigs.•Vietnamese HP-PRRSV SRV07 isolate was less severe.•Attenuated Type 2 PRRSV vaccine induced protection against HP-PRRSV challenge.•Vaccine protection was not sterilizing immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant reproductive losses in the sow herd and respiratory disease in growing pigs. The virus belongs to the family Arteriviridae and there are two major genotypes. Type 1 is represented by Lelystad virus, the European prototype virus, and Type 2 is represented by the North American prototype virus, VR-2332. Depending on husbandry, immune status of the herd, and virulence of the isolate, the severity of disease and magnitude of economic loss can be variable. Vaccine use is not always successful indicating a lack of cross-protection between vaccine strains and circulating wild-type viruses. To date, there is no clear method to demonstrate...
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titleEfficacy of Type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs
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•Chinese HP-PRRSV JXwn06 isolate induced severe disease in 10-week-old pigs.•Vietnamese HP-PRRSV SRV07 isolate was less severe.•Attenuated Type 2 PRRSV vaccine induced protection against HP-PRRSV challenge.•Vaccine protection was not sterilizing immunity.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant reproductive losses in the sow herd and respiratory disease in growing pigs. The virus belongs to the family Arteriviridae and there are two major genotypes. Type 1 is represented by Lelystad virus, the European prototype virus, and Type 2 is represented by the North American prototype virus, VR-2332. Depending on husbandry, immune status of the herd, and virulence of the isolate, the severity of disease and magnitude of economic loss can be variable. Vaccine use is not always successful indicating a lack of cross-protection between vaccine strains and circulating wild-type viruses. To date, there is no clear method to demonstrate...

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•Chinese HP-PRRSV JXwn06 isolate induced severe disease in 10-week-old pigs.•Vietnamese HP-PRRSV SRV07 isolate was less severe.•Attenuated Type 2 PRRSV vaccine induced protection against HP-PRRSV challenge.•Vaccine protection was not sterilizing immunity.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant reproductive losses in the sow herd and respiratory disease in growing pigs. The virus belongs to the family Arteriviridae and there are two major genotypes. Type 1 is represented by Lelystad virus, the European prototype virus, and Type 2 is represented by the North American prototype virus, VR-2332. Depending on husbandry, immune status of the herd, and virulence of the isolate, the severity of disease and magnitude of economic loss can be variable. Vaccine use is not always successful indicating a lack of cross-protection between vaccine strains and circulating wild-type viruses. To date, there is no clear method to demonstrate...

pubElsevier Ltd
doi10.1016/j.vaccine.2014.09.046
lad01Vaccine
date2014-11-12