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Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica

We have provided a detailed structural analysis of porcine alveolar macrophage TLR3 extracellular domain (ECD). The porcine TLR3-ECD contains 18 leucine-rich repeats (LRRs) consisting of blocks of consensus motifs and non-consensus motifs containing insertions. Excluding the N-terminal and C-termina... Full description

Journal Title: Veterinary Immunology and Immunopathology 2011, Vol.142(1), pp.57-63
Main Author: Sacco, Randy E
Other Authors: Nicholson, Tracy L , Waters, Theresa E , Brockmeier, Susan L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0165-2427 ; E-ISSN: 1873-2534 ; DOI: 10.1016/j.vetimm.2011.04.008
Link: https://www.sciencedirect.com/science/article/pii/S0165242711001255
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recordid: elsevier_sdoi_10_1016_j_vetimm_2011_04_008
title: Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica
format: Article
creator:
  • Sacco, Randy E
  • Nicholson, Tracy L
  • Waters, Theresa E
  • Brockmeier, Susan L
subjects:
  • Porcine
  • Toll-Like Receptor
  • Leucine-Rich Repeat
  • Influenza Virus
  • Bordetella
  • Medicine
  • Veterinary Medicine
ispartof: Veterinary Immunology and Immunopathology, 2011, Vol.142(1), pp.57-63
description: We have provided a detailed structural analysis of porcine alveolar macrophage TLR3 extracellular domain (ECD). The porcine TLR3-ECD contains 18 leucine-rich repeats (LRRs) consisting of blocks of consensus motifs and non-consensus motifs containing insertions. Excluding the N-terminal and C-terminal LRRs, porcine TLR3 has two LRRs with insertions, resulting in one LRR of 39 amino acids and another LRR of 34 amino acids. Furthermore, we have conducted the first examination of the regulated expression of porcine alveolar macrophage TLR3 during in vivo co-infection with influenza virus and . There was a bi-phasic upregulation of porcine TLR3 during influenza virus infection (day 1 and day 10 post-infection). Co-infection resulted in an enhanced expression of porcine TLR3 only at day 1 post-infection. Interestingly, induced an upregulation in alveolar macrophage TLR3 expression at day 10 post-infection. Based on our work and that of...
language: eng
source:
identifier: ISSN: 0165-2427 ; E-ISSN: 1873-2534 ; DOI: 10.1016/j.vetimm.2011.04.008
fulltext: fulltext
issn:
  • 0165-2427
  • 01652427
  • 1873-2534
  • 18732534
url: Link


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titlePorcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica
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subjectPorcine ; Toll-Like Receptor ; Leucine-Rich Repeat ; Influenza Virus ; Bordetella ; Medicine ; Veterinary Medicine
descriptionWe have provided a detailed structural analysis of porcine alveolar macrophage TLR3 extracellular domain (ECD). The porcine TLR3-ECD contains 18 leucine-rich repeats (LRRs) consisting of blocks of consensus motifs and non-consensus motifs containing insertions. Excluding the N-terminal and C-terminal LRRs, porcine TLR3 has two LRRs with insertions, resulting in one LRR of 39 amino acids and another LRR of 34 amino acids. Furthermore, we have conducted the first examination of the regulated expression of porcine alveolar macrophage TLR3 during in vivo co-infection with influenza virus and . There was a bi-phasic upregulation of porcine TLR3 during influenza virus infection (day 1 and day 10 post-infection). Co-infection resulted in an enhanced expression of porcine TLR3 only at day 1 post-infection. Interestingly, induced an upregulation in alveolar macrophage TLR3 expression at day 10 post-infection. Based on our work and that of...
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We have provided a detailed structural analysis of porcine alveolar macrophage TLR3 extracellular domain (ECD). The porcine TLR3-ECD contains 18 leucine-rich repeats (LRRs) consisting of blocks of consensus motifs and non-consensus motifs containing insertions. Excluding the N-terminal and C-terminal LRRs, porcine TLR3 has two LRRs with insertions, resulting in one LRR of 39 amino acids and another LRR of 34 amino acids. Furthermore, we have conducted the first examination of the regulated expression of porcine alveolar macrophage TLR3 during in vivo co-infection with influenza virus and

. There was a bi-phasic upregulation of porcine TLR3 during influenza virus infection (day 1 and day 10 post-infection). Co-infection resulted in an enhanced expression of porcine TLR3 only at day 1 post-infection. Interestingly,

induced an upregulation in alveolar macrophage TLR3 expression at day 10 post-infection. Based on our work and that of...

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We have provided a detailed structural analysis of porcine alveolar macrophage TLR3 extracellular domain (ECD). The porcine TLR3-ECD contains 18 leucine-rich repeats (LRRs) consisting of blocks of consensus motifs and non-consensus motifs containing insertions. Excluding the N-terminal and C-terminal LRRs, porcine TLR3 has two LRRs with insertions, resulting in one LRR of 39 amino acids and another LRR of 34 amino acids. Furthermore, we have conducted the first examination of the regulated expression of porcine alveolar macrophage TLR3 during in vivo co-infection with influenza virus and

. There was a bi-phasic upregulation of porcine TLR3 during influenza virus infection (day 1 and day 10 post-infection). Co-infection resulted in an enhanced expression of porcine TLR3 only at day 1 post-infection. Interestingly,

induced an upregulation in alveolar macrophage TLR3 expression at day 10 post-infection. Based on our work and that of...

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