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Cochlea Radiation Dose Correlates with Hearing Loss After Stereotactic Radiosurgery of Vestibular Schwannoma

For multisession radiosurgery, no published data relate the volume and dose of cochlear irradiation to quantified risk of hearing loss. We conducted a retrospective, dosimetric study to evaluate the relationship between hearing loss after stereotactic radiosurgery (SRS) and the dose-volume of irradi... Full description

Journal Title: World Neurosurgery September 2013, Vol.80(3-4), pp.359-363
Main Author: Hayden Gephart, Melanie G
Other Authors: Hansasuta, Ake , Balise, Raymond R , Choi, Clara , Sakamoto, Gordon T , Venteicher, Andrew S , Soltys, Scott G , Gibbs, Iris C , Harsh, Griffith R , Adler, John R , Chang, Steven D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1878-8750 ; E-ISSN: 1878-8769 ; DOI: 10.1016/j.wneu.2012.04.001
Link: https://www.sciencedirect.com/science/article/pii/S1878875012004536
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recordid: elsevier_sdoi_10_1016_j_wneu_2012_04_001
title: Cochlea Radiation Dose Correlates with Hearing Loss After Stereotactic Radiosurgery of Vestibular Schwannoma
format: Article
creator:
  • Hayden Gephart, Melanie G
  • Hansasuta, Ake
  • Balise, Raymond R
  • Choi, Clara
  • Sakamoto, Gordon T
  • Venteicher, Andrew S
  • Soltys, Scott G
  • Gibbs, Iris C
  • Harsh, Griffith R
  • Adler, John R
  • Chang, Steven D
subjects:
  • Cochlea
  • Hearing Preservation
  • Radiation
  • Stereotactic Radiosurgery
  • Vestibular Schwannoma
ispartof: World Neurosurgery, September 2013, Vol.80(3-4), pp.359-363
description: For multisession radiosurgery, no published data relate the volume and dose of cochlear irradiation to quantified risk of hearing loss. We conducted a retrospective, dosimetric study to evaluate the relationship between hearing loss after stereotactic radiosurgery (SRS) and the dose-volume of irradiated cochlea. Cochlear dose data were retrospectively collected on consecutive patients who underwent SRS (18 Gy in 3 sessions) for vestibular schwanoma between 1999 and 2005 at Stanford University Hospital. Inclusion criteria included Gardner-Robertson (GR) grade I or II hearing prior to radiosurgical treatment, complete audiograms, and magnetic resonance imaging (MRI) follow-up. A cochlea dose-volume histogram was generated for each of the 94 patients who qualified for this study. GR grade I-II hearing posttreatment was maintained in 74% of patients (70/94). Median time to last follow-up audiogram was 2.4 years (range 0.4–8.9) and to last MRI was 3.6 years (range 0.5–9.4). Each higher level of cochlear irradiation was associated with increased risk of hearing loss. Larger cochlear volume was associated with lower risk of hearing loss. Controlling for differences in cochlear volume among subjects, each additional mm of cochlea receiving 10 to 16 Gy (single session equivalent doses of 6.6–10.1 Gy ) significantly increased the odds of hearing loss by approximately 5%. Larger cochlear volume is associated with lower risk of hearing loss following trisession SRS for vestibular schwannoma. Controlling for this phenomenon, higher radiation dose and larger irradiated cochlear volume are significantly associated with higher risk of hearing loss. This study confirms and quantifies the risk of hearing loss following trisession SRS for vestibular schwannoma.
language: eng
source:
identifier: ISSN: 1878-8750 ; E-ISSN: 1878-8769 ; DOI: 10.1016/j.wneu.2012.04.001
fulltext: fulltext
issn:
  • 1878-8750
  • 18788750
  • 1878-8769
  • 18788769
url: Link


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titleCochlea Radiation Dose Correlates with Hearing Loss After Stereotactic Radiosurgery of Vestibular Schwannoma
creatorHayden Gephart, Melanie G ; Hansasuta, Ake ; Balise, Raymond R ; Choi, Clara ; Sakamoto, Gordon T ; Venteicher, Andrew S ; Soltys, Scott G ; Gibbs, Iris C ; Harsh, Griffith R ; Adler, John R ; Chang, Steven D
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subjectCochlea ; Hearing Preservation ; Radiation ; Stereotactic Radiosurgery ; Vestibular Schwannoma
descriptionFor multisession radiosurgery, no published data relate the volume and dose of cochlear irradiation to quantified risk of hearing loss. We conducted a retrospective, dosimetric study to evaluate the relationship between hearing loss after stereotactic radiosurgery (SRS) and the dose-volume of irradiated cochlea. Cochlear dose data were retrospectively collected on consecutive patients who underwent SRS (18 Gy in 3 sessions) for vestibular schwanoma between 1999 and 2005 at Stanford University Hospital. Inclusion criteria included Gardner-Robertson (GR) grade I or II hearing prior to radiosurgical treatment, complete audiograms, and magnetic resonance imaging (MRI) follow-up. A cochlea dose-volume histogram was generated for each of the 94 patients who qualified for this study. GR grade I-II hearing posttreatment was maintained in 74% of patients (70/94). Median time to last follow-up audiogram was 2.4 years (range 0.4–8.9) and to last MRI was 3.6 years (range 0.5–9.4). Each higher level of cochlear irradiation was associated with increased risk of hearing loss. Larger cochlear volume was associated with lower risk of hearing loss. Controlling for differences in cochlear volume among subjects, each additional mm of cochlea receiving 10 to 16 Gy (single session equivalent doses of 6.6–10.1 Gy ) significantly increased the odds of hearing loss by approximately 5%. Larger cochlear volume is associated with lower risk of hearing loss following trisession SRS for vestibular schwannoma. Controlling for this phenomenon, higher radiation dose and larger irradiated cochlear volume are significantly associated with higher risk of hearing loss. This study confirms and quantifies the risk of hearing loss following trisession SRS for vestibular schwannoma.
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