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Lysophospholipid mediators in the vasculature

Acting through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [1–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable... Full description

Journal Title: Experimental Cell Research 01 May 2015, Vol.333(2), pp.190-194
Main Author: Mueller, Paul
Other Authors: Ye, Shaojing , Morris, Andrew , Smyth, Susan S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0014-4827 ; E-ISSN: 1090-2422 ; DOI: 10.1016/j.yexcr.2015.03.016
Link: http://dx.doi.org/10.1016/j.yexcr.2015.03.016
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recordid: elsevier_sdoi_10_1016_j_yexcr_2015_03_016
title: Lysophospholipid mediators in the vasculature
format: Article
creator:
  • Mueller, Paul
  • Ye, Shaojing
  • Morris, Andrew
  • Smyth, Susan S
subjects:
  • Lysophosphatidic Acid
  • Autotaxin
  • Lipid Phosphate Phosphatase
  • Endothelial Cells
  • Smooth Muscle Cells
  • Atherosclerosis
  • Lysophosphatidic Acid
  • Autotaxin
  • Lipid Phosphate Phosphatase
  • Endothelial Cells
  • Smooth Muscle Cells
  • Atherosclerosis
  • Biology
ispartof: Experimental Cell Research, 01 May 2015, Vol.333(2), pp.190-194
description: Acting through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [1–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable responses to LPA [11, 12], which likely regulate blood vessel development and contribute to vascular pathology. The bioactive effects of LPA are mediated by a family of G-protein coupled receptors with at least six members (termed LPA1-6 that are encoded by the LPAR genes in humans and Lpar in mice) [1–3]. LPA may also serve as a ligand for the receptor for advanced glycation end products (RAGE) [13]. This review summarizes evidence to support a role for LPA signaling in vascular biology based on studies of LPA receptors and enzymes that produce or metabolize the lipid (Figure 1).
language: eng
source:
identifier: ISSN: 0014-4827 ; E-ISSN: 1090-2422 ; DOI: 10.1016/j.yexcr.2015.03.016
fulltext: fulltext
issn:
  • 0014-4827
  • 00144827
  • 1090-2422
  • 10902422
url: Link


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subjectLysophosphatidic Acid ; Autotaxin ; Lipid Phosphate Phosphatase ; Endothelial Cells ; Smooth Muscle Cells ; Atherosclerosis ; Lysophosphatidic Acid ; Autotaxin ; Lipid Phosphate Phosphatase ; Endothelial Cells ; Smooth Muscle Cells ; Atherosclerosis ; Biology
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descriptionActing through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [1–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable responses to LPA [11, 12], which likely regulate blood vessel development and contribute to vascular pathology. The bioactive effects of LPA are mediated by a family of G-protein coupled receptors with at least six members (termed LPA1-6 that are encoded by the LPAR genes in humans and Lpar in mice) [1–3]. LPA may also serve as a ligand for the receptor for advanced glycation end products (RAGE) [13]. This review summarizes evidence to support a role for LPA signaling in vascular biology based on studies of LPA receptors and enzymes that produce or metabolize the lipid (Figure 1).
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