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Phosphatidylinositol 4-kinases: Function, structure, and inhibition

The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (α and β) and t... Full description

Journal Title: Experimental Cell Research 01 October 2015, Vol.337(2), pp.136-145
Main Author: Boura, Evzen
Other Authors: Nencka, Radim
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0014-4827 ; E-ISSN: 1090-2422 ; DOI: 10.1016/j.yexcr.2015.03.028
Link: https://www.sciencedirect.com/science/article/pii/S0014482715002323
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recordid: elsevier_sdoi_10_1016_j_yexcr_2015_03_028
title: Phosphatidylinositol 4-kinases: Function, structure, and inhibition
format: Article
creator:
  • Boura, Evzen
  • Nencka, Radim
subjects:
  • Phosphatidylinositol 4-Kinase
  • Inhibitor
  • Crystal Structure
  • Virus
  • Biology
ispartof: Experimental Cell Research, 01 October 2015, Vol.337(2), pp.136-145
description: The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (α and β) and two type III enzymes (α and β). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.
language: eng
source:
identifier: ISSN: 0014-4827 ; E-ISSN: 1090-2422 ; DOI: 10.1016/j.yexcr.2015.03.028
fulltext: fulltext
issn:
  • 0014-4827
  • 00144827
  • 1090-2422
  • 10902422
url: Link


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descriptionThe phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (α and β) and two type III enzymes (α and β). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.
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