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Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro

The purpose of this study was to evaluate the effects of recombinant human relaxin on the uterine artery and myometrial contractility in pregnant rats. Uterine artery and myometrial rings from mid and term pregnant rats were used. Relaxin effect was studied on phenylephrine-induced contraction in th... Full description

Journal Title: American Journal of Obstetrics and Gynecology June 2003, Vol.188(6), pp.1468-1476
Main Author: Longo, Monica
Other Authors: Jain, Venu , Vedernikov, Yuri P , Garfield, Robert E , Saade, George R
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-9378 ; E-ISSN: 1097-6868 ; DOI: 10.1067/mob.2003.454
Link: https://www.sciencedirect.com/science/article/pii/S0002937803004101
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recordid: elsevier_sdoi_10_1067_mob_2003_454
title: Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro
format: Article
creator:
  • Longo, Monica
  • Jain, Venu
  • Vedernikov, Yuri P
  • Garfield, Robert E
  • Saade, George R
subjects:
  • Myometrium
  • Nitric Oxide
  • Pregnant Rat
  • Relaxin
  • Uterine Artery
  • Medicine
ispartof: American Journal of Obstetrics and Gynecology, June 2003, Vol.188(6), pp.1468-1476
description: The purpose of this study was to evaluate the effects of recombinant human relaxin on the uterine artery and myometrial contractility in pregnant rats. Uterine artery and myometrial rings from mid and term pregnant rats were used. Relaxin effect was studied on phenylephrine-induced contraction in the presence or absence of nitric oxide synthase inhibitor, nitro-l-arginine methyl ester, soluble guanylate cyclase inhibitor, 1H-oxadiazolo-quinoxaline-1-one, or adenylate cyclase inhibitor, SQ-22,536. The myometrial inhibitory effect of relaxin was studied on spontaneous and oxytocin- or protein kinase C activator-induced contractions. Uterine artery relaxation by relaxin was greater at mid pregnancy compared with term. Relaxin effect was decreased by SQ-22,536, 1H-oxadiazolo-quinoxaline-1-one and nitro-l-arginine methyl ester at mid pregnancy. Relaxin inhibited spontaneous contractions at mid pregnancy...
language: eng
source:
identifier: ISSN: 0002-9378 ; E-ISSN: 1097-6868 ; DOI: 10.1067/mob.2003.454
fulltext: fulltext
issn:
  • 0002-9378
  • 00029378
  • 1097-6868
  • 10976868
url: Link


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titleEffects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro
creatorLongo, Monica ; Jain, Venu ; Vedernikov, Yuri P ; Garfield, Robert E ; Saade, George R
ispartofAmerican Journal of Obstetrics and Gynecology, June 2003, Vol.188(6), pp.1468-1476
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subjectMyometrium ; Nitric Oxide ; Pregnant Rat ; Relaxin ; Uterine Artery ; Medicine
descriptionThe purpose of this study was to evaluate the effects of recombinant human relaxin on the uterine artery and myometrial contractility in pregnant rats. Uterine artery and myometrial rings from mid and term pregnant rats were used. Relaxin effect was studied on phenylephrine-induced contraction in the presence or absence of nitric oxide synthase inhibitor, nitro-l-arginine methyl ester, soluble guanylate cyclase inhibitor, 1H-oxadiazolo-quinoxaline-1-one, or adenylate cyclase inhibitor, SQ-22,536. The myometrial inhibitory effect of relaxin was studied on spontaneous and oxytocin- or protein kinase C activator-induced contractions. Uterine artery relaxation by relaxin was greater at mid pregnancy compared with term. Relaxin effect was decreased by SQ-22,536, 1H-oxadiazolo-quinoxaline-1-one and nitro-l-arginine methyl ester at mid pregnancy. Relaxin inhibited spontaneous contractions at mid pregnancy...
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