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Predicting missing biomarker data in a longitudinal study of Alzheimer disease

Objective:To investigate predictors of missing data in a longitudinal study of Alzheimer disease (AD).Methods:The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a clinic-based, multicenter, longitudinal study with blood, CSF, PET, and MRI scans repeatedly measured in 229 participants with nor... Full description

Main Author: Lo, Raymond Y.
Other Authors: Jagust, William J. , Aisen, Paul , Jack, Clifford R. , Toga, Arthur W. , Beckett, Laurel , Gamst, Anthony , Soares, Holly , C. Green, Robert , Montine, Tom , Thomas, Ronald G. , Donohue, Michael , Walter, Sarah , Dale, Anders , Bernstein, Matthew , Felmlee, Joel , Fox, Nick , Thompson, Paul , Schuff, Norbert , Alexander, Gene , DeCarli, Charles , Bandy, Dan , Chen, Kewei , Morris, John , Lee, Virginia M.-Y. , Korecka, Magdalena , Crawford, Karen , Neu, Scott , Harvey, Danielle , Kornak, John , Saykin, Andrew J. , Foroud, Tatiana M. , Potkin, Steven , Shen, Li , Buckholtz, Neil , Kaye, Jeffrey , Dolen, Sara , Quinn, Joseph , Schneider, Lon , Pawluczyk, Sonia , Spann, Bryan M. , Brewer, James , Vanderswag, Helen , Heidebrink, Judith L. , Lord, Joanne L. , Petersen, Ronald , Johnson, Kris , Doody, Rachelle S. , Villanueva-Meyer, Javier , Chowdhury, Munir , Stern, Yaakov , Honig, Lawrence S. , Bell, Karen L. , Morris, John C. , Mintun, Mark A. , Schneider, Stacy , Marson, Daniel , Griffith, Randall , Clark, David , Grossman, Hillel , Tang, Cheuk , Marzloff, George , Toledo-Morrell, Leylade , Shah, Raj C. , Duara, Ranjan , Varon, Daniel , Roberts, Peggy , Albert, Marilyn S. , Pedroso, Julia , Toroney, Jaimie , Rusinek, Henry , de Leon, Mony J , De Santi, Susan M , Doraiswamy, P. Murali , Petrella, Jeffrey R. , Aiello, Marilyn , Clark, Christopher M. , Pham, Cassie , Nunez, Jessica , Smith, Charles D. , Given, Curtis A. , Hardy, Peter , Lopez, Oscar L. , Oakley, MaryAnn , Simpson, Donna M. , Ismail, M. Saleem , Brand, Connie , Richard, Jennifer , Mulnard, Ruth A. , Thai, Gaby , Mc-Adams-Ortiz, Catherine , Diaz-Arrastia, Ramon , Martin-Cook, Kristen , DeVous, Michael , Levey, Allan I. , Lah, James J. , Cellar, Janet S. , Burns, Jeffrey M. , Anderson, Heather S. , Laubinger, Mary M. , Bartzokis, George , Silverman, Daniel H.S. , Lu, Po H. , Graff-Radford MBBCH, Neill R , Parfitt, Francine , Johnson, Heather , Farlow, Martin , Herring, Scott , Hake, Ann M. , van Dyck, Christopher H. , MacAvoy, Martha G. , Benincasa, Amanda L. , Chertkow, Howard , Bergman, Howard , Hosein, Chris , Black, Sandra , Graham, Simon , Caldwell, Curtis , Hsiung, Ging-Yuek Robin , Feldman, Howard , Assaly, Michele , Kertesz, Andrew , Rogers, John , Trost, Dick , Bernick, Charles , Munic, Donna , Wu, Chuang-Kuo , Johnson, Nancy , Mesulam, Marsel , Sadowsky, Carl , Martinez, Walter , Villena, Teresa , Turner, Scott , Johnson, Kathleen B. , Behan, Kelly E. , Sperling, Reisa A. , Rentz, Dorene M. , Johnson, Keith A. , Rosen, Allyson , Tinklenberg, Jared , Ashford, Wes , Sabbagh, Marwan , Connor, Donald , Jacobson, Sandra , Killiany, Ronald , Norbash, Alexander , Nair, Anil , Obisesan, Thomas O. , Jayam-Trouth, Annapurni , Wang, Paul , Lerner, Alan , Hudson, Leon , Ogrocki, Paula , DeCarli, Charles , Fletcher, Evan , Carmichael, Owen , Kittur, Smita , Mirje, Seema , Borrie, Michael , Lee, T-Y , Bartha, Dr Rob , Johnson, Sterling , Asthana, Sanjay , Carlsson, Cynthia M. , Potkin, Steven G. , Preda, Adrian , Nguyen, Dana , Tariot, Pierre , Fleisher, Adam , Reeder, Stephanie , Bates, Vernice , Capote, Horacio , Rainka, Michelle , Hendin, Barry A. , Scharre, Douglas W. , Kataki, Maria , Zimmerman, Earl A. , Celmins, Dzintra , Brown, Alice D. , Gandy, Sam , Marenberg, Marjorie E. , Rovner, Barry W. , Pearlson, Godfrey , Anderson, Karen , Saykin, Andrew J. , Santulli, Robert B. , Englert, Jessica , Williamson, Jeff D. , Sink, Kaycee M. , Watkins, Franklin , Ott, Brian R. , Wu, Chuang-Kuo , Cohen, Ronald , Salloway, Stephen , Malloy, Paul , Correia, Stephen , Rosen, Howard J. , Miller, Bruce L. , Mintzer, Jacobo
Format: Electronic Article Electronic Article
Language: English
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Quelle: eScholarship
Created: 2012
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title: Predicting missing biomarker data in a longitudinal study of Alzheimer disease
format: Article
creator:
  • Lo, Raymond Y.
  • Jagust, William J.
  • Aisen, Paul
  • Jack, Clifford R.
  • Toga, Arthur W.
  • Beckett, Laurel
  • Gamst, Anthony
  • Soares, Holly
  • C. Green, Robert
  • Montine, Tom
  • Thomas, Ronald G.
  • Donohue, Michael
  • Walter, Sarah
  • Dale, Anders
  • Bernstein, Matthew
  • Felmlee, Joel
  • Fox, Nick
  • Thompson, Paul
  • Schuff, Norbert
  • Alexander, Gene
  • DeCarli, Charles
  • Bandy, Dan
  • Chen, Kewei
  • Morris, John
  • Lee, Virginia M.-Y.
  • Korecka, Magdalena
  • Crawford, Karen
  • Neu, Scott
  • Harvey, Danielle
  • Kornak, John
  • Saykin, Andrew J.
  • Foroud, Tatiana M.
  • Potkin, Steven
  • Shen, Li
  • Buckholtz, Neil
  • Kaye, Jeffrey
  • Dolen, Sara
  • Quinn, Joseph
  • Schneider, Lon
  • Pawluczyk, Sonia
  • Spann, Bryan M.
  • Brewer, James
  • Vanderswag, Helen
  • Heidebrink, Judith L.
  • Lord, Joanne L.
  • Petersen, Ronald
  • Johnson, Kris
  • Doody, Rachelle S.
  • Villanueva-Meyer, Javier
  • Chowdhury, Munir
  • Stern, Yaakov
  • Honig, Lawrence S.
  • Bell, Karen L.
  • Morris, John C.
  • Mintun, Mark A.
  • Schneider, Stacy
  • Marson, Daniel
  • Griffith, Randall
  • Clark, David
  • Grossman, Hillel
  • Tang, Cheuk
  • Marzloff, George
  • Toledo-Morrell, Leylade
  • Shah, Raj C.
  • Duara, Ranjan
  • Varon, Daniel
  • Roberts, Peggy
  • Albert, Marilyn S.
  • Pedroso, Julia
  • Toroney, Jaimie
  • Rusinek, Henry
  • de Leon, Mony J
  • De Santi, Susan M
  • Doraiswamy, P. Murali
  • Petrella, Jeffrey R.
  • Aiello, Marilyn
  • Clark, Christopher M.
  • Pham, Cassie
  • Nunez, Jessica
  • Smith, Charles D.
  • Given, Curtis A.
  • Hardy, Peter
  • Lopez, Oscar L.
  • Oakley, MaryAnn
  • Simpson, Donna M.
  • Ismail, M. Saleem
  • Brand, Connie
  • Richard, Jennifer
  • Mulnard, Ruth A.
  • Thai, Gaby
  • Mc-Adams-Ortiz, Catherine
  • Diaz-Arrastia, Ramon
  • Martin-Cook, Kristen
  • DeVous, Michael
  • Levey, Allan I.
  • Lah, James J.
  • Cellar, Janet S.
  • Burns, Jeffrey M.
  • Anderson, Heather S.
  • Laubinger, Mary M.
  • Bartzokis, George
  • Silverman, Daniel H.S.
  • Lu, Po H.
  • Graff-Radford MBBCH, Neill R
  • Parfitt, Francine
  • Johnson, Heather
  • Farlow, Martin
  • Herring, Scott
  • Hake, Ann M.
  • van Dyck, Christopher H.
  • MacAvoy, Martha G.
  • Benincasa, Amanda L.
  • Chertkow, Howard
  • Bergman, Howard
  • Hosein, Chris
  • Black, Sandra
  • Graham, Simon
  • Caldwell, Curtis
  • Hsiung, Ging-Yuek Robin
  • Feldman, Howard
  • Assaly, Michele
  • Kertesz, Andrew
  • Rogers, John
  • Trost, Dick
  • Bernick, Charles
  • Munic, Donna
  • Wu, Chuang-Kuo
  • Johnson, Nancy
  • Mesulam, Marsel
  • Sadowsky, Carl
  • Martinez, Walter
  • Villena, Teresa
  • Turner, Scott
  • Johnson, Kathleen B.
  • Behan, Kelly E.
  • Sperling, Reisa A.
  • Rentz, Dorene M.
  • Johnson, Keith A.
  • Rosen, Allyson
  • Tinklenberg, Jared
  • Ashford, Wes
  • Sabbagh, Marwan
  • Connor, Donald
  • Jacobson, Sandra
  • Killiany, Ronald
  • Norbash, Alexander
  • Nair, Anil
  • Obisesan, Thomas O.
  • Jayam-Trouth, Annapurni
  • Wang, Paul
  • Lerner, Alan
  • Hudson, Leon
  • Ogrocki, Paula
  • DeCarli, Charles
  • Fletcher, Evan
  • Carmichael, Owen
  • Kittur, Smita
  • Mirje, Seema
  • Borrie, Michael
  • Lee, T-Y
  • Bartha, Dr Rob
  • Johnson, Sterling
  • Asthana, Sanjay
  • Carlsson, Cynthia M.
  • Potkin, Steven G.
  • Preda, Adrian
  • Nguyen, Dana
  • Tariot, Pierre
  • Fleisher, Adam
  • Reeder, Stephanie
  • Bates, Vernice
  • Capote, Horacio
  • Rainka, Michelle
  • Hendin, Barry A.
  • Scharre, Douglas W.
  • Kataki, Maria
  • Zimmerman, Earl A.
  • Celmins, Dzintra
  • Brown, Alice D.
  • Gandy, Sam
  • Marenberg, Marjorie E.
  • Rovner, Barry W.
  • Pearlson, Godfrey
  • Anderson, Karen
  • Saykin, Andrew J.
  • Santulli, Robert B.
  • Englert, Jessica
  • Williamson, Jeff D.
  • Sink, Kaycee M.
  • Watkins, Franklin
  • Ott, Brian R.
  • Wu, Chuang-Kuo
  • Cohen, Ronald
  • Salloway, Stephen
  • Malloy, Paul
  • Correia, Stephen
  • Rosen, Howard J.
  • Miller, Bruce L.
  • Mintzer, Jacobo
subjects:
  • Medicine and Health Sciences
ispartof:
description: Objective:To investigate predictors of missing data in a longitudinal study of Alzheimer disease (AD).Methods:The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a clinic-based, multicenter, longitudinal study with blood, CSF, PET, and MRI scans repeatedly measured in 229 participants with normal cognition (NC), 397 with mild cognitive impairment (MCI), and 193 with mild AD during 2005–2007. We used univariate and multivariable logistic regression models to examine the associations between baseline demographic/clinical features and loss of biomarker follow-ups in ADNI.Results:CSF studies tended to recruit and retain patients with MCI with more AD-like features, including lower levels of baseline CSF Aβ42. Depression was the major predictor for MCI dropouts, while family history of AD kept more patients with AD enrolled in PET and MRI studies. Poor cognitive performance was associated with loss of follow-up in most biomarker studies, even among NC participants. The presence of vascular risk factors seemed more critical than cognitive function for predicting dropouts in AD.Conclusion:The missing data are not missing completely at random in ADNI and likely conditional on certain features in addition to cognitive function. Missing data predictors vary across biomarkers and even MCI and AD groups do not share the same missing data pattern. Understanding the missing data structure may help in the design of future longitudinal studies and clinical trials in AD.
language: eng
source: eScholarship
identifier:
fulltext: fulltext_linktorsrc
url: Link


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titlePredicting missing biomarker data in a longitudinal study of Alzheimer disease
creatorLo, Raymond Y. ; Jagust, William J. ; Aisen, Paul ; Jack, Clifford R. ; Toga, Arthur W. ; Beckett, Laurel ; Gamst, Anthony ; Soares, Holly ; C. Green, Robert ; Montine, Tom ; Thomas, Ronald G. ; Donohue, Michael ; Walter, Sarah ; Dale, Anders ; Bernstein, Matthew ; Felmlee, Joel ; Fox, Nick ; Thompson, Paul ; Schuff, Norbert ; Alexander, Gene ; DeCarli, Charles ; Bandy, Dan ; Chen, Kewei ; Morris, John ; Lee, Virginia M.-Y. ; Korecka, Magdalena ; Crawford, Karen ; Neu, Scott ; Harvey, Danielle ; Kornak, John ; Saykin, Andrew J. ; Foroud, Tatiana M. ; Potkin, Steven ; Shen, Li ; Buckholtz, Neil ; Kaye, Jeffrey ; Dolen, Sara ; Quinn, Joseph ; Schneider, Lon ; Pawluczyk, Sonia ; Spann, Bryan M. ; Brewer, James ; Vanderswag, Helen ; Heidebrink, Judith L. ; Lord, Joanne L. ; Petersen, Ronald ; Johnson, Kris ; Doody, Rachelle S. ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Stern, Yaakov ; Honig, Lawrence S. ; Bell, Karen L. ; Morris, John C. ; Mintun, Mark A. ; Schneider, Stacy ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Grossman, Hillel ; Tang, Cheuk ; Marzloff, George ; Toledo-Morrell, Leylade ; Shah, Raj C. ; Duara, Ranjan ; Varon, Daniel ; Roberts, Peggy ; Albert, Marilyn S. ; Pedroso, Julia ; Toroney, Jaimie ; Rusinek, Henry ; de Leon, Mony J ; De Santi, Susan M ; Doraiswamy, P. Murali ; Petrella, Jeffrey R. ; Aiello, Marilyn ; Clark, Christopher M. ; Pham, Cassie ; Nunez, Jessica ; Smith, Charles D. ; Given, Curtis A. ; Hardy, Peter ; Lopez, Oscar L. ; Oakley, MaryAnn ; Simpson, Donna M. ; Ismail, M. Saleem ; Brand, Connie ; Richard, Jennifer ; Mulnard, Ruth A. ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Diaz-Arrastia, Ramon ; Martin-Cook, Kristen ; DeVous, Michael ; Levey, Allan I. ; Lah, James J. ; Cellar, Janet S. ; Burns, Jeffrey M. ; Anderson, Heather S. ; Laubinger, Mary M. ; Bartzokis, George ; Silverman, Daniel H.S. ; Lu, Po H. ; Graff-Radford MBBCH, Neill R ; Parfitt, Francine ; Johnson, Heather ; Farlow, Martin ; Herring, Scott ; Hake, Ann M. ; van Dyck, Christopher H. ; MacAvoy, Martha G. ; Benincasa, Amanda L. ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Graham, Simon ; Caldwell, Curtis ; Hsiung, Ging-Yuek Robin ; Feldman, Howard ; Assaly, Michele ; Kertesz, Andrew ; Rogers, John ; Trost, Dick ; Bernick, Charles ; Munic, Donna ; Wu, Chuang-Kuo ; Johnson, Nancy ; Mesulam, Marsel ; Sadowsky, Carl ; Martinez, Walter ; Villena, Teresa ; Turner, Scott ; Johnson, Kathleen B. ; Behan, Kelly E. ; Sperling, Reisa A. ; Rentz, Dorene M. ; Johnson, Keith A. ; Rosen, Allyson ; Tinklenberg, Jared ; Ashford, Wes ; Sabbagh, Marwan ; Connor, Donald ; Jacobson, Sandra ; Killiany, Ronald ; Norbash, Alexander ; Nair, Anil ; Obisesan, Thomas O. ; Jayam-Trouth, Annapurni ; Wang, Paul ; Lerner, Alan ; Hudson, Leon ; Ogrocki, Paula ; DeCarli, Charles ; Fletcher, Evan ; Carmichael, Owen ; Kittur, Smita ; Mirje, Seema ; Borrie, Michael ; Lee, T-Y ; Bartha, Dr Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia M. ; Potkin, Steven G. ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Fleisher, Adam ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Hendin, Barry A. ; Scharre, Douglas W. ; Kataki, Maria ; Zimmerman, Earl A. ; Celmins, Dzintra ; Brown, Alice D. ; Gandy, Sam ; Marenberg, Marjorie E. ; Rovner, Barry W. ; Pearlson, Godfrey ; Anderson, Karen ; Saykin, Andrew J. ; Santulli, Robert B. ; Englert, Jessica ; Williamson, Jeff D. ; Sink, Kaycee M. ; Watkins, Franklin ; Ott, Brian R. ; Wu, Chuang-Kuo ; Cohen, Ronald ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen ; Rosen, Howard J. ; Miller, Bruce L. ; Mintzer, Jacobo
creationdate2012
subjectMedicine and Health Sciences
descriptionObjective:To investigate predictors of missing data in a longitudinal study of Alzheimer disease (AD).Methods:The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a clinic-based, multicenter, longitudinal study with blood, CSF, PET, and MRI scans repeatedly measured in 229 participants with normal cognition (NC), 397 with mild cognitive impairment (MCI), and 193 with mild AD during 2005–2007. We used univariate and multivariable logistic regression models to examine the associations between baseline demographic/clinical features and loss of biomarker follow-ups in ADNI.Results:CSF studies tended to recruit and retain patients with MCI with more AD-like features, including lower levels of baseline CSF Aβ42. Depression was the major predictor for MCI dropouts, while family history of AD kept more patients with AD enrolled in PET and MRI studies. Poor cognitive performance was associated with loss of follow-up in most biomarker studies, even among NC participants. The presence of vascular risk factors seemed more critical than cognitive function for predicting dropouts in AD.Conclusion:The missing data are not missing completely at random in ADNI and likely conditional on certain features in addition to cognitive function. Missing data predictors vary across biomarkers and even MCI and AD groups do not share the same missing data pattern. Understanding the missing data structure may help in the design of future longitudinal studies and clinical trials in AD.
languageeng
relationLo, Raymond Y.; Jagust, William J.; Aisen, Paul; Jack, Clifford R.; Toga, Arthur W.; Beckett, Laurel;  et al.(2012). Predicting missing biomarker data in a longitudinal study of Alzheimer disease. Neurology, 78(18), 1376 - 1382. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6000433n
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0Lo, Raymond Y.
1Jagust, William J.
2Aisen, Paul
3Jack, Clifford R.
4Toga, Arthur W.
5Beckett, Laurel
6Gamst, Anthony
7Soares, Holly
8C. Green, Robert
9Montine, Tom
10Thomas, Ronald G.
11Donohue, Michael
12Walter, Sarah
13Dale, Anders
14Bernstein, Matthew
15Felmlee, Joel
16Fox, Nick
17Thompson, Paul
18Schuff, Norbert
19Alexander, Gene
20DeCarli, Charles
21Bandy, Dan
22Chen, Kewei
23Morris, John
24Lee, Virginia M.-Y.
25Korecka, Magdalena
26Crawford, Karen
27Neu, Scott
28Harvey, Danielle
29Kornak, John
30Saykin, Andrew J.
31Foroud, Tatiana M.
32Potkin, Steven
33Shen, Li
34Buckholtz, Neil
35Kaye, Jeffrey
36Dolen, Sara
37Quinn, Joseph
38Schneider, Lon
39Pawluczyk, Sonia
40Spann, Bryan M.
41Brewer, James
42Vanderswag, Helen
43Heidebrink, Judith L.
44Lord, Joanne L.
45Petersen, Ronald
46Johnson, Kris
47Doody, Rachelle S.
48Villanueva-Meyer, Javier
49Chowdhury, Munir
50Stern, Yaakov
51Honig, Lawrence S.
52Bell, Karen L.
53Morris, John C.
54Mintun, Mark A.
55Schneider, Stacy
56Marson, Daniel
57Griffith, Randall
58Clark, David
59Grossman, Hillel
60Tang, Cheuk
61Marzloff, George
62Toledo-Morrell, Leylade
63Shah, Raj C.
64Duara, Ranjan
65Varon, Daniel
66Roberts, Peggy
67Albert, Marilyn S.
68Pedroso, Julia
69Toroney, Jaimie
70Rusinek, Henry
71de Leon, Mony J
72De Santi, Susan M
73Doraiswamy, P. Murali
74Petrella, Jeffrey R.
75Aiello, Marilyn
76Clark, Christopher M.
77Pham, Cassie
78Nunez, Jessica
79Smith, Charles D.
80Given, Curtis A.
81Hardy, Peter
82Lopez, Oscar L.
83Oakley, MaryAnn
84Simpson, Donna M.
85Ismail, M. Saleem
86Brand, Connie
87Richard, Jennifer
88Mulnard, Ruth A.
89Thai, Gaby
90Mc-Adams-Ortiz, Catherine
91Diaz-Arrastia, Ramon
92Martin-Cook, Kristen
93DeVous, Michael
94Levey, Allan I.
95Lah, James J.
96Cellar, Janet S.
97Burns, Jeffrey M.
98Anderson, Heather S.
99Laubinger, Mary M.
100...
titlePredicting missing biomarker data in a longitudinal study of Alzheimer disease
descriptionObjective:To investigate predictors of missing data in a longitudinal study of Alzheimer disease (AD).Methods:The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a clinic-based, multicenter, longitudinal study with blood, CSF, PET, and MRI scans repeatedly measured in 229 participants with normal cognition (NC), 397 with mild cognitive impairment (MCI), and 193 with mild AD during 2005–2007. We used univariate and multivariable logistic regression models to examine the associations between baseline demographic/clinical features and loss of biomarker follow-ups in ADNI.Results:CSF studies tended to recruit and retain patients with MCI with more AD-like features, including lower levels of baseline CSF Aβ42. Depression was the major predictor for MCI dropouts, while family history of AD kept more patients with AD enrolled in PET and MRI studies. Poor cognitive performance was associated with loss of follow-up in most biomarker studies, even among NC participants. The presence of vascular risk factors seemed more critical than cognitive function for predicting dropouts in AD.Conclusion:The missing data are not missing completely at random in ADNI and likely conditional on certain features in addition to cognitive function. Missing data predictors vary across biomarkers and even MCI and AD groups do not share the same missing data pattern. Understanding the missing data structure may help in the design of future longitudinal studies and clinical trials in AD.
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titlePredicting missing biomarker data in a longitudinal study of Alzheimer disease
authorLo, Raymond Y. ; Jagust, William J. ; Aisen, Paul ; Jack, Clifford R. ; Toga, Arthur W. ; Beckett, Laurel ; Gamst, Anthony ; Soares, Holly ; C. Green, Robert ; Montine, Tom ; Thomas, Ronald G. ; Donohue, Michael ; Walter, Sarah ; Dale, Anders ; Bernstein, Matthew ; Felmlee, Joel ; Fox, Nick ; Thompson, Paul ; Schuff, Norbert ; Alexander, Gene ; DeCarli, Charles ; Bandy, Dan ; Chen, Kewei ; Morris, John ; Lee, Virginia M.-Y. ; Korecka, Magdalena ; Crawford, Karen ; Neu, Scott ; Harvey, Danielle ; Kornak, John ; Saykin, Andrew J. ; Foroud, Tatiana M. ; Potkin, Steven ; Shen, Li ; Buckholtz, Neil ; Kaye, Jeffrey ; Dolen, Sara ; Quinn, Joseph ; Schneider, Lon ; Pawluczyk, Sonia ; Spann, Bryan M. ; Brewer, James ; Vanderswag, Helen ; Heidebrink, Judith L. ; Lord, Joanne L. ; Petersen, Ronald ; Johnson, Kris ; Doody, Rachelle S. ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Stern, Yaakov ; Honig, Lawrence S. ; Bell, Karen L. ; Morris, John C. ; Mintun, Mark A. ; Schneider, Stacy ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Grossman, Hillel ; Tang, Cheuk ; Marzloff, George ; Toledo-Morrell, Leylade ; Shah, Raj C. ; Duara, Ranjan ; Varon, Daniel ; Roberts, Peggy ; Albert, Marilyn S. ; Pedroso, Julia ; Toroney, Jaimie ; Rusinek, Henry ; de Leon, Mony J ; De Santi, Susan M ; Doraiswamy, P. Murali ; Petrella, Jeffrey R. ; Aiello, Marilyn ; Clark, Christopher M. ; Pham, Cassie ; Nunez, Jessica ; Smith, Charles D. ; Given, Curtis A. ; Hardy, Peter ; Lopez, Oscar L. ; Oakley, MaryAnn ; Simpson, Donna M. ; Ismail, M. Saleem ; Brand, Connie ; Richard, Jennifer ; Mulnard, Ruth A. ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Diaz-Arrastia, Ramon ; Martin-Cook, Kristen ; DeVous, Michael ; Levey, Allan I. ; Lah, James J. ; Cellar, Janet S. ; Burns, Jeffrey M. ; Anderson, Heather S. ; Laubinger, Mary M. ; Bartzokis, George ; Silverman, Daniel H.S. ; Lu, Po H. ; Graff-Radford MBBCH, Neill R ; Parfitt, Francine ; Johnson, Heather ; Farlow, Martin ; Herring, Scott ; Hake, Ann M. ; van Dyck, Christopher H. ; MacAvoy, Martha G. ; Benincasa, Amanda L. ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Graham, Simon ; Caldwell, Curtis ; Hsiung, Ging-Yuek Robin ; Feldman, Howard ; Assaly, Michele ; Kertesz, Andrew ; Rogers, John ; Trost, Dick ; Bernick, Charles ; Munic, Donna ; Wu, Chuang-Kuo ; Johnson, Nancy ; Mesulam, Marsel ; Sadowsky, Carl ; Martinez, Walter ; Villena, Teresa ; Turner, Scott ; Johnson, Kathleen B. ; Behan, Kelly E. ; Sperling, Reisa A. ; Rentz, Dorene M. ; Johnson, Keith A. ; Rosen, Allyson ; Tinklenberg, Jared ; Ashford, Wes ; Sabbagh, Marwan ; Connor, Donald ; Jacobson, Sandra ; Killiany, Ronald ; Norbash, Alexander ; Nair, Anil ; Obisesan, Thomas O. ; Jayam-Trouth, Annapurni ; Wang, Paul ; Lerner, Alan ; Hudson, Leon ; Ogrocki, Paula ; DeCarli, Charles ; Fletcher, Evan ; Carmichael, Owen ; Kittur, Smita ; Mirje, Seema ; Borrie, Michael ; Lee, T-Y ; Bartha, Dr Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia M. ; Potkin, Steven G. ; Preda, Adrian ; Nguyen, Dana ; Tariot, Pierre ; Fleisher, Adam ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Hendin, Barry A. ; Scharre, Douglas W. ; Kataki, Maria ; Zimmerman, Earl A. ; Celmins, Dzintra ; Brown, Alice D. ; Gandy, Sam ; Marenberg, Marjorie E. ; Rovner, Barry W. ; Pearlson, Godfrey ; Anderson, Karen ; Saykin, Andrew J. ; Santulli, Robert B. ; Englert, Jessica ; Williamson, Jeff D. ; Sink, Kaycee M. ; Watkins, Franklin ; Ott, Brian R. ; Wu, Chuang-Kuo ; Cohen, Ronald ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen ; Rosen, Howard J. ; Miller, Bruce L. ; Mintzer, Jacobo
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topicMedicine and Health Sciences
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creatorcontrib
0Lo, Raymond Y.
1Jagust, William J.
2Aisen, Paul
3Jack, Clifford R.
4Toga, Arthur W.
5Beckett, Laurel
6Gamst, Anthony
7Soares, Holly
8C. Green, Robert
9Montine, Tom
10Thomas, Ronald G.
11Donohue, Michael
12Walter, Sarah
13Dale, Anders
14Bernstein, Matthew
15Felmlee, Joel
16Fox, Nick
17Thompson, Paul
18Schuff, Norbert
19Alexander, Gene
20DeCarli, Charles
21Bandy, Dan
22Chen, Kewei
23Morris, John
24Lee, Virginia M.-Y.
25Korecka, Magdalena
26Crawford, Karen
27Neu, Scott
28Harvey, Danielle
29Kornak, John
30Saykin, Andrew J.
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38Schneider, Lon
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41Brewer, James
42Vanderswag, Helen
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47Doody, Rachelle S.
48Villanueva-Meyer, Javier
49Chowdhury, Munir
50Stern, Yaakov
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52Bell, Karen L.
53Morris, John C.
54Mintun, Mark A.
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56Marson, Daniel
57Griffith, Randall
58Clark, David
59Grossman, Hillel
60Tang, Cheuk
61Marzloff, George
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68Pedroso, Julia
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70Rusinek, Henry
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72De Santi, Susan M
73Doraiswamy, P. Murali
74Petrella, Jeffrey R.
75Aiello, Marilyn
76Clark, Christopher M.
77Pham, Cassie
78Nunez, Jessica
79Smith, Charles D.
80Given, Curtis A.
81Hardy, Peter
82Lopez, Oscar L.
83Oakley, MaryAnn
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87Richard, Jennifer
88Mulnard, Ruth A.
89Thai, Gaby
90Mc-Adams-Ortiz, Catherine
91Diaz-Arrastia, Ramon
92Martin-Cook, Kristen
93DeVous, Michael
94Levey, Allan I.
95Lah, James J.
96Cellar, Janet S.
97Burns, Jeffrey M.
98Anderson, Heather S.
99Laubinger, Mary M.
100...
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1Jagust, William J.
2Aisen, Paul
3Jack, Clifford R.
4Toga, Arthur W.
5Beckett, Laurel
6Gamst, Anthony
7Soares, Holly
8C. Green, Robert
9Montine, Tom
10Thomas, Ronald G.
11Donohue, Michael
12Walter, Sarah
13Dale, Anders
14Bernstein, Matthew
15Felmlee, Joel
16Fox, Nick
17Thompson, Paul
18Schuff, Norbert
19Alexander, Gene
20DeCarli, Charles
21Bandy, Dan
22Chen, Kewei
23Morris, John
24Lee, Virginia M.-Y.
25Korecka, Magdalena
26Crawford, Karen
27Neu, Scott
28Harvey, Danielle
29Kornak, John
30Saykin, Andrew J.
31Foroud, Tatiana M.
32Potkin, Steven
33Shen, Li
34Buckholtz, Neil
35Kaye, Jeffrey
36Dolen, Sara
37Quinn, Joseph
38Schneider, Lon
39Pawluczyk, Sonia
40Spann, Bryan M.
41Brewer, James
42Vanderswag, Helen
43Heidebrink, Judith L.
44Lord, Joanne L.
45Petersen, Ronald
46Johnson, Kris
47Doody, Rachelle S.
48Villanueva-Meyer, Javier
49Chowdhury, Munir
50Stern, Yaakov
51Honig, Lawrence S.
52Bell, Karen L.
53Morris, John C.
54Mintun, Mark A.
55Schneider, Stacy
56Marson, Daniel
57Griffith, Randall
58Clark, David
59Grossman, Hillel
60Tang, Cheuk
61Marzloff, George
62Toledo-Morrell, Leylade
63Shah, Raj C.
64Duara, Ranjan
65Varon, Daniel
66Roberts, Peggy
67Albert, Marilyn S.
68Pedroso, Julia
69Toroney, Jaimie
70Rusinek, Henry
71de Leon, Mony J
72De Santi, Susan M
73Doraiswamy, P. Murali
74Petrella, Jeffrey R.
75Aiello, Marilyn
76Clark, Christopher M.
77Pham, Cassie
78Nunez, Jessica
79Smith, Charles D.
80Given, Curtis A.
81Hardy, Peter
82Lopez, Oscar L.
83Oakley, MaryAnn
84Simpson, Donna M.
85Ismail, M. Saleem
86Brand, Connie
87Richard, Jennifer
88Mulnard, Ruth A.
89Thai, Gaby
90Mc-Adams-Ortiz, Catherine
91Diaz-Arrastia, Ramon
92Martin-Cook, Kristen
93DeVous, Michael
94Levey, Allan I.
95Lah, James J.
96Cellar, Janet S.
97Burns, Jeffrey M.
98Anderson, Heather S.
99Laubinger, Mary M.
100...
atitlePredicting missing biomarker data in a longitudinal study of Alzheimer disease
risdateJOUR
pages1376 - 1382
formatjournal
genrearticle
ristypeJOUR
abstractObjective:To investigate predictors of missing data in a longitudinal study of Alzheimer disease (AD).Methods:The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a clinic-based, multicenter, longitudinal study with blood, CSF, PET, and MRI scans repeatedly measured in 229 participants with normal cognition (NC), 397 with mild cognitive impairment (MCI), and 193 with mild AD during 2005–2007. We used univariate and multivariable logistic regression models to examine the associations between baseline demographic/clinical features and loss of biomarker follow-ups in ADNI.Results:CSF studies tended to recruit and retain patients with MCI with more AD-like features, including lower levels of baseline CSF Aβ42. Depression was the major predictor for MCI dropouts, while family history of AD kept more patients with AD enrolled in PET and MRI studies. Poor cognitive performance was associated with loss of follow-up in most biomarker studies, even among NC participants. The presence of vascular risk factors seemed more critical than cognitive function for predicting dropouts in AD.Conclusion:The missing data are not missing completely at random in ADNI and likely conditional on certain features in addition to cognitive function. Missing data predictors vary across biomarkers and even MCI and AD groups do not share the same missing data pattern. Understanding the missing data structure may help in the design of future longitudinal studies and clinical trials in AD.
copUniversity of California
pubeScholarship
urlhttp://www.escholarship.org/uc/item/6000433n
oafree_for_read
date2012-05-01