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Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men

Objective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year... Full description

Journal Title: International journal of obesity : journal of the International Association for the Study of Obesity 2007, Vol.31(2), pp.245-253
Main Author: Linna , M.S.
Other Authors: Borg , P. , Kukkonen-Harjula , K. , Fogelholm , M. , Nenonen , A. , Ahotupa , M. , Vasankari , T.J.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Men
ID: ISSN: 0307-0565
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recordid: faoagrisUS201300779674
title: Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men
format: Article
creator:
  • Linna , M.S.
  • Borg , P.
  • Kukkonen-Harjula , K.
  • Fogelholm , M.
  • Nenonen , A.
  • Ahotupa , M.
  • Vasankari , T.J.
subjects:
  • Very Low Calorie Diet
  • Weight Loss
  • Weight Control
  • Cardiovascular Diseases
  • Obesity
  • Dienoic Fatty Acids
  • Blood Lipids
  • Atherosclerosis
  • Men
  • Lipid Peroxidation
  • Risk Factors
  • Low Density Lipoprotein
ispartof: International journal of obesity : journal of the International Association for the Study of Obesity, 2007, Vol.31(2), pp.245-253
description: Objective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year follow-up. Ninety men entered and 68 (76%) completed the study. Subjects were analyzed as one group and after division into two subgroups: 20 most successful men in maintaining the lost weight (subgroup 1) and the remaining (n=48) men (subgroup 2). Ox-LDL was measured by quantifying the amount of conjugated dienes in LDL particles. Results: The mean (+/-s.d.) weight reduction at the end of the WRP (n=68) was 14% (confidence interval (CI) 12.9-14.7%, 14.5+/-4.2 kg, P
language: eng
source:
identifier: ISSN: 0307-0565
fulltext: fulltext
issn:
  • 03070565
  • 0307-0565
url: Link


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titleSuccessful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men
creatorLinna , M.S. ; Borg , P. ; Kukkonen-Harjula , K. ; Fogelholm , M. ; Nenonen , A. ; Ahotupa , M. ; Vasankari , T.J.
ispartofInternational journal of obesity : journal of the International Association for the Study of Obesity, 2007, Vol.31(2), pp.245-253
identifierISSN: 0307-0565
subjectVery Low Calorie Diet ; Weight Loss ; Weight Control ; Cardiovascular Diseases ; Obesity ; Dienoic Fatty Acids ; Blood Lipids ; Atherosclerosis ; Men ; Lipid Peroxidation ; Risk Factors ; Low Density Lipoprotein
descriptionObjective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year follow-up. Ninety men entered and 68 (76%) completed the study. Subjects were analyzed as one group and after division into two subgroups: 20 most successful men in maintaining the lost weight (subgroup 1) and the remaining (n=48) men (subgroup 2). Ox-LDL was measured by quantifying the amount of conjugated dienes in LDL particles. Results: The mean (+/-s.d.) weight reduction at the end of the WRP (n=68) was 14% (confidence interval (CI) 12.9-14.7%, 14.5+/-4.2 kg, P<0.001). Ox-LDL decreased by 22% (CI 16.9-28.1, 12.3+/-15.4 micromol/l, P<0.001). At the end of the 2-year follow-up, the regain in weight from the end of the WRP was 11% (CI 9.0-12.4, 9.6+/-6.2 kg, P<0.001). The regain in ox-LDL was 30% (CI 18.7-41.2, 8.2+/-15.4 micromol/l, P<0.001). In subgroup 1 vs 2, the respective regains were 3% (CI 0.9-4.2, 2.2+/-3.0 kg, P=0.006) vs 14% (CI 12.7-15.6, 12.9+/-4.0 kg, P<0.001) regarding weight and 9% (2.0+/-6.9 micromol/l, P=NS) vs 39% (CI 23.7-53.9, 11.2+/-17.2 micromol/l, P less than or equal to 0.001) in ox-LDL. Conclusion: The favorable changes seen in ox-LDL particles and serum lipids during weight reduction could be maintained by keeping the weight reduced, which may indicate decreased risk of atherosclerosis. But weight regain causes a resurge of ox-LDL. ; Includes references ; p. 245-253.
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titleSuccessful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men
descriptionObjective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year follow-up. Ninety men entered and 68 (76%) completed the study. Subjects were analyzed as one group and after division into two subgroups: 20 most successful men in maintaining the lost weight (subgroup 1) and the remaining (n=48) men (subgroup 2). Ox-LDL was measured by quantifying the amount of conjugated dienes in LDL particles. Results: The mean (+/-s.d.) weight reduction at the end of the WRP (n=68) was 14% (confidence interval (CI) 12.9-14.7%, 14.5+/-4.2 kg, P<0.001). Ox-LDL decreased by 22% (CI 16.9-28.1, 12.3+/-15.4 micromol/l, P<0.001). At the end of the 2-year follow-up, the regain in weight from the end of the WRP was 11% (CI 9.0-12.4, 9.6+/-6.2 kg, P<0.001). The regain in ox-LDL was 30% (CI 18.7-41.2, 8.2+/-15.4 micromol/l, P<0.001). In subgroup 1 vs 2, the respective regains were 3% (CI 0.9-4.2, 2.2+/-3.0 kg, P=0.006) vs 14% (CI 12.7-15.6, 12.9+/-4.0 kg, P<0.001) regarding weight and 9% (2.0+/-6.9 micromol/l, P=NS) vs 39% (CI 23.7-53.9, 11.2+/-17.2 micromol/l, P less than or equal to 0.001) in ox-LDL. Conclusion: The favorable changes seen in ox-LDL particles and serum lipids during weight reduction could be maintained by keeping the weight reduced, which may indicate decreased risk of atherosclerosis. But weight regain causes a resurge of ox-LDL. ; Includes references ; p. 245-253.
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5Dienoic Fatty Acids
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10Risk Factors
11Low Density Lipoprotein
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abstractObjective: We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men. Methods: A 2-month weight reduction phase (WRP) with a very-low-energy diet was followed by a 6-month weight maintenance period and an unsupervised 2-year follow-up. Ninety men entered and 68 (76%) completed the study. Subjects were analyzed as one group and after division into two subgroups: 20 most successful men in maintaining the lost weight (subgroup 1) and the remaining (n=48) men (subgroup 2). Ox-LDL was measured by quantifying the amount of conjugated dienes in LDL particles. Results: The mean (+/-s.d.) weight reduction at the end of the WRP (n=68) was 14% (confidence interval (CI) 12.9-14.7%, 14.5+/-4.2 kg, P<0.001). Ox-LDL decreased by 22% (CI 16.9-28.1, 12.3+/-15.4 micromol/l, P<0.001). At the end of the 2-year follow-up, the regain in weight from the end of the WRP was 11% (CI 9.0-12.4, 9.6+/-6.2 kg, P<0.001). The regain in ox-LDL was 30% (CI 18.7-41.2, 8.2+/-15.4 micromol/l, P<0.001). In subgroup 1 vs 2, the respective regains were 3% (CI 0.9-4.2, 2.2+/-3.0 kg, P=0.006) vs 14% (CI 12.7-15.6, 12.9+/-4.0 kg, P<0.001) regarding weight and 9% (2.0+/-6.9 micromol/l, P=NS) vs 39% (CI 23.7-53.9, 11.2+/-17.2 micromol/l, P less than or equal to 0.001) in ox-LDL. Conclusion: The favorable changes seen in ox-LDL particles and serum lipids during weight reduction could be maintained by keeping the weight reduced, which may indicate decreased risk of atherosclerosis. But weight regain causes a resurge of ox-LDL.
doi10.1038/sj.ijo.0803413
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