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Calcium and dairy products inhibit weight and fat regain during ad libitum consumption following energy restriction in Ap2-Agouti transgenic mice

We demonstrated previously that dietary calcium suppression of calcitriol reduces adipocyte Ca(2+), suppresses lipogenesis, and increases lipid utilization during energy restriction. Notably, dairy calcium sources exert markedly greater effects. To determine the effects of dietary calcium and dairy... Full description

Journal Title: Journal of nutrition 2004, Vol.134(11), pp.3054-3060
Main Author: Sun , X.
Other Authors: Zemel , M.B.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-3166
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recordid: faoagrisUS201300961054
title: Calcium and dairy products inhibit weight and fat regain during ad libitum consumption following energy restriction in Ap2-Agouti transgenic mice
format: Article
creator:
  • Sun , X.
  • Zemel , M.B.
subjects:
  • Calcium
  • Body Fat
  • Dairy Products
  • Obesity
  • Dietary Minerals
  • Lipogenesis
  • Animal Models
  • Adipocytes
  • Low Calorie Diet
  • Mineral Content
  • Mice
  • Repletion
  • Energy Intake
  • Lipid Content
  • Ad Libitum Feeding
  • Enzyme Activity
  • Nutrient Partitioning
  • Transgenic Animals
  • Weight Gain
  • Nutritional Status
ispartof: Journal of nutrition, 2004, Vol.134(11), pp.3054-3060
description: We demonstrated previously that dietary calcium suppression of calcitriol reduces adipocyte Ca(2+), suppresses lipogenesis, and increases lipid utilization during energy restriction. Notably, dairy calcium sources exert markedly greater effects. To determine the effects of dietary calcium and dairy products on energy partitioning during subsequent refeeding, we induced obesity in aP2-agouti transgenic mice with a high-fat/high-sucrose diet, then restricted energy intake from a high-calcium (1.3%) diet for 6 wk to induce fat loss, and then provided free access to a low-calcium (0.4%) diet or to high-calcium (1.3%) diets that utilized either calcium-fortified foods or dairy products (milk or yogurt) for 6 wk. Refeeding the low-calcium diet caused the regain of all weight and fat, whereas all high-calcium diets reduced fat gain by 55% (P 10-fold, P < 0.001) increase in skeletal muscle peroxisome proliferator-activated receptor-alpha expression. All 3 high-calcium diets produced significant increases in lipolysis, decreases in fatty acid synthase expression and activity, and reduced fat regain (P < 0.03), but the 2 dairy-containing high-calcium diets exerted significantly greater effects on regain (P < 0.01). Thus, high-Ca diets elicit a shift in energy partitioning and reduction of weight gain during refeeding, with dairy Ca sources exerting markedly greater effects. ; Includes references ; p. 3054-3060.
language: eng
source:
identifier: ISSN: 0022-3166
fulltext: fulltext
issn:
  • 00223166
  • 0022-3166
url: Link


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titleCalcium and dairy products inhibit weight and fat regain during ad libitum consumption following energy restriction in Ap2-Agouti transgenic mice
creatorSun , X. ; Zemel , M.B.
ispartofJournal of nutrition, 2004, Vol.134(11), pp.3054-3060
identifierISSN: 0022-3166
subjectCalcium ; Body Fat ; Dairy Products ; Obesity ; Dietary Minerals ; Lipogenesis ; Animal Models ; Adipocytes ; Low Calorie Diet ; Mineral Content ; Mice ; Repletion ; Energy Intake ; Lipid Content ; Ad Libitum Feeding ; Enzyme Activity ; Nutrient Partitioning ; Transgenic Animals ; Weight Gain ; Nutritional Status
descriptionWe demonstrated previously that dietary calcium suppression of calcitriol reduces adipocyte Ca(2+), suppresses lipogenesis, and increases lipid utilization during energy restriction. Notably, dairy calcium sources exert markedly greater effects. To determine the effects of dietary calcium and dairy products on energy partitioning during subsequent refeeding, we induced obesity in aP2-agouti transgenic mice with a high-fat/high-sucrose diet, then restricted energy intake from a high-calcium (1.3%) diet for 6 wk to induce fat loss, and then provided free access to a low-calcium (0.4%) diet or to high-calcium (1.3%) diets that utilized either calcium-fortified foods or dairy products (milk or yogurt) for 6 wk. Refeeding the low-calcium diet caused the regain of all weight and fat, whereas all high-calcium diets reduced fat gain by 55% (P 10-fold, P < 0.001) increase in skeletal muscle peroxisome proliferator-activated receptor-alpha expression. All 3 high-calcium diets produced significant increases in lipolysis, decreases in fatty acid synthase expression and activity, and reduced fat regain (P < 0.03), but the 2 dairy-containing high-calcium diets exerted significantly greater effects on regain (P < 0.01). Thus, high-Ca diets elicit a shift in energy partitioning and reduction of weight gain during refeeding, with dairy Ca sources exerting markedly greater effects. ; Includes references ; p. 3054-3060.
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titleCalcium and dairy products inhibit weight and fat regain during ad libitum consumption following energy restriction in Ap2-Agouti transgenic mice
descriptionWe demonstrated previously that dietary calcium suppression of calcitriol reduces adipocyte Ca(2+), suppresses lipogenesis, and increases lipid utilization during energy restriction. Notably, dairy calcium sources exert markedly greater effects. To determine the effects of dietary calcium and dairy products on energy partitioning during subsequent refeeding, we induced obesity in aP2-agouti transgenic mice with a high-fat/high-sucrose diet, then restricted energy intake from a high-calcium (1.3%) diet for 6 wk to induce fat loss, and then provided free access to a low-calcium (0.4%) diet or to high-calcium (1.3%) diets that utilized either calcium-fortified foods or dairy products (milk or yogurt) for 6 wk. Refeeding the low-calcium diet caused the regain of all weight and fat, whereas all high-calcium diets reduced fat gain by 55% (P 10-fold, P < 0.001) increase in skeletal muscle peroxisome proliferator-activated receptor-alpha expression. All 3 high-calcium diets produced significant increases in lipolysis, decreases in fatty acid synthase expression and activity, and reduced fat regain (P < 0.03), but the 2 dairy-containing high-calcium diets exerted significantly greater effects on regain (P < 0.01). Thus, high-Ca diets elicit a shift in energy partitioning and reduction of weight gain during refeeding, with dairy Ca sources exerting markedly greater effects. ; Includes references ; p. 3054-3060.
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15Enzyme Activity
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abstractWe demonstrated previously that dietary calcium suppression of calcitriol reduces adipocyte Ca(2+), suppresses lipogenesis, and increases lipid utilization during energy restriction. Notably, dairy calcium sources exert markedly greater effects. To determine the effects of dietary calcium and dairy products on energy partitioning during subsequent refeeding, we induced obesity in aP2-agouti transgenic mice with a high-fat/high-sucrose diet, then restricted energy intake from a high-calcium (1.3%) diet for 6 wk to induce fat loss, and then provided free access to a low-calcium (0.4%) diet or to high-calcium (1.3%) diets that utilized either calcium-fortified foods or dairy products (milk or yogurt) for 6 wk. Refeeding the low-calcium diet caused the regain of all weight and fat, whereas all high-calcium diets reduced fat gain by 55% (P 10-fold, P < 0.001) increase in skeletal muscle peroxisome proliferator-activated receptor-alpha expression. All 3 high-calcium diets produced significant increases in lipolysis, decreases in fatty acid synthase expression and activity, and reduced fat regain (P < 0.03), but the 2 dairy-containing high-calcium diets exerted significantly greater effects on regain (P < 0.01). Thus, high-Ca diets elicit a shift in energy partitioning and reduction of weight gain during refeeding, with dairy Ca sources exerting markedly greater effects.
doi10.1093/jn/134.11.3054
eissn15416100