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Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and Its glucuronide conjugates in mice

A series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietar... Full description

Journal Title: Journal of agricultural and food chemistry 2005, Vol.53(18), pp.7302-7306
Main Author: Asai , A.
Other Authors: Nakano , T. , Takahashi , M. , Nagao , A.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0021-8561
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recordid: faoagrisUS201301026130
title: Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and Its glucuronide conjugates in mice
format: Article
creator:
  • Asai , A.
  • Nakano , T.
  • Takahashi , M.
  • Nagao , A.
subjects:
  • Mice
  • Gardenia Jasminoides
  • Fruits (Plant Anatomy)
  • Glycosides
  • Blood Plasma
  • Blood Chemistry
  • Carotenoids
  • Intestinal Absorption
  • Oral Administration
  • Crocins
  • Crocetin
  • Glucuronides
ispartof: Journal of agricultural and food chemistry, 2005, Vol.53(18), pp.7302-7306
description: A series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietary crocetin and crocins remains unknown. In the present study, we investigated the intestinal absorption of orally administered crocetin and crocins in mice. Orally administered crocetin was rapidly absorbed into the blood circulation and was present in plasma as an intact free form and as glucuronide conjugates (crocetin-monoglucuronide and -diglucuronide). Crocetin and its glucuronide conjugates were also found in crocins-administered mouse plasma, whereas intact crocins (glycoside forms) were not detected. These results indicate that orally administered crocins are hydrolyzed to crocetin before or during intestinal absorption, and absorbed crocetin is partly metabolized to mono- and diglucuronide conjugates. ; Includes references ; p. 7302-7306.
language: eng
source:
identifier: ISSN: 0021-8561
fulltext: fulltext
issn:
  • 00218561
  • 0021-8561
url: Link


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titleOrally administered crocetin and crocins are absorbed into blood plasma as crocetin and Its glucuronide conjugates in mice
creatorAsai , A. ; Nakano , T. ; Takahashi , M. ; Nagao , A.
ispartofJournal of agricultural and food chemistry, 2005, Vol.53(18), pp.7302-7306
identifierISSN: 0021-8561
subjectMice ; Gardenia Jasminoides ; Fruits (Plant Anatomy) ; Glycosides ; Blood Plasma ; Blood Chemistry ; Carotenoids ; Intestinal Absorption ; Oral Administration ; Crocins ; Crocetin ; Glucuronides
descriptionA series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietary crocetin and crocins remains unknown. In the present study, we investigated the intestinal absorption of orally administered crocetin and crocins in mice. Orally administered crocetin was rapidly absorbed into the blood circulation and was present in plasma as an intact free form and as glucuronide conjugates (crocetin-monoglucuronide and -diglucuronide). Crocetin and its glucuronide conjugates were also found in crocins-administered mouse plasma, whereas intact crocins (glycoside forms) were not detected. These results indicate that orally administered crocins are hydrolyzed to crocetin before or during intestinal absorption, and absorbed crocetin is partly metabolized to mono- and diglucuronide conjugates. ; Includes references ; p. 7302-7306.
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titleOrally administered crocetin and crocins are absorbed into blood plasma as crocetin and Its glucuronide conjugates in mice
descriptionA series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietary crocetin and crocins remains unknown. In the present study, we investigated the intestinal absorption of orally administered crocetin and crocins in mice. Orally administered crocetin was rapidly absorbed into the blood circulation and was present in plasma as an intact free form and as glucuronide conjugates (crocetin-monoglucuronide and -diglucuronide). Crocetin and its glucuronide conjugates were also found in crocins-administered mouse plasma, whereas intact crocins (glycoside forms) were not detected. These results indicate that orally administered crocins are hydrolyzed to crocetin before or during intestinal absorption, and absorbed crocetin is partly metabolized to mono- and diglucuronide conjugates. ; Includes references ; p. 7302-7306.
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abstractA series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietary crocetin and crocins remains unknown. In the present study, we investigated the intestinal absorption of orally administered crocetin and crocins in mice. Orally administered crocetin was rapidly absorbed into the blood circulation and was present in plasma as an intact free form and as glucuronide conjugates (crocetin-monoglucuronide and -diglucuronide). Crocetin and its glucuronide conjugates were also found in crocins-administered mouse plasma, whereas intact crocins (glycoside forms) were not detected. These results indicate that orally administered crocins are hydrolyzed to crocetin before or during intestinal absorption, and absorbed crocetin is partly metabolized to mono- and diglucuronide conjugates.
doi10.1021/jf0509355
eissn15205118
date2005-09-07