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Comparison of 3 ad libitum diets for weight-loss maintenance, risk of cardiovascular disease, and diabetes: a 6-mo randomized, controlled trial

BACKGROUND: The optimal dietary content and type of fat and carbohydrate for weight management has been debated for decades. OBJECTIVE: The objective was to compare the effects of 3 ad libitum diets on the maintenance of an initial weight loss of greater-than-or-equal8% and risk factors for CVD and... Full description

Journal Title: American journal of clinical nutrition AJN 2008, Vol.88(5), pp.1232-1241
Main Author: Due , Anette
Other Authors: Larsen , Thomas M. , Mu , Huiling , Hermansen , Kjeld , Stender , Steen , Astrup , Arne
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-9165
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recordid: faoagrisUS201301557499
title: Comparison of 3 ad libitum diets for weight-loss maintenance, risk of cardiovascular disease, and diabetes: a 6-mo randomized, controlled trial
format: Article
creator:
  • Due , Anette
  • Larsen , Thomas M.
  • Mu , Huiling
  • Hermansen , Kjeld
  • Stender , Steen
  • Astrup , Arne
subjects:
  • Obesity-Related Diseases
  • Diet
  • Weight Loss
  • Insulin
  • Psoriasis
  • Cardiovascular Diseases
  • Obesity
  • Body Mass Index
  • Chronic Diseases
  • Food Intake
  • Insulin Resistance
  • Women
  • Cyclosporins
  • Low Calorie Diet
  • Dose Response
  • Patients
  • Noninsulin-Dependent Diabetes Mellitus
  • Overweight
  • Weight Control
  • Drug Therapy
  • Randomized Clinical Trials
  • Nutritional Intervention
  • Risk Factors
  • Monounsaturated Fatty Acids
  • Plaque Psoriasis
ispartof: American journal of clinical nutrition AJN, 2008, Vol.88(5), pp.1232-1241
description: BACKGROUND: The optimal dietary content and type of fat and carbohydrate for weight management has been debated for decades. OBJECTIVE: The objective was to compare the effects of 3 ad libitum diets on the maintenance of an initial weight loss of greater-than-or-equal8% and risk factors for CVD and diabetes during a 6-mo controlled dietary intervention. DESIGN: Nondiabetic overweight or obese [mean ± SD body mass index (in kg/m²): 31.5 ± 2.6] men (n = 55) and women (n = 76) aged 28.2 ± 4.8 y were randomly assigned to a diet providing a moderate amount of fat (35-45% of energy) and >20% of fat as monounsaturated fatty acids (MUFA diet; n = 54), to a low-fat (20-30% of energy) diet (LF diet; n = 51), or to a control diet (35% of energy as fat; n = 26). Protein constituted 10-20% of energy in all 3 diets. All foods were provided free of charge from a purpose-built supermarket. RESULTS: More subjects dropped out of the MUFA (28%) group than out of the LF group (16%) and control group (8%) (MUFA compared with control: P < 0.05). All groups regained weight (MUFA: 2.5 ± 0.7 kg; LF: 2.2 ± 0.7 kg; and control: 3.8 ± 0.8 kg; NS). Body fat regain was lower in the LF (0.6 ± 0.6%) and MUFA (1.6 ± 0.6%) groups than in the control group (2.6 ± 0.5%) (P < 0.05). In the MUFA group, fasting insulin decreased by 2.6 ± 3.5 pmol/L, the homeostasis model assessment of insulin resistance by 0.17 ± 0.13, and the ratio of LDL to HDL by 0.33 ± 0.13; in the LF group, these variables increased by 4.3 ± 3.0 pmol/L (P < 0.08) and 0.17 ± 0.10 (P < 0.05) and decreased by 0.02 ± 0.09 (P = 0.005), respectively; and in the control group, increased by 14.0 ± 4.3 pmol/L (P < 0.001), 0.57 ± 0.17 (P < 0.001), and 0.05 ± 0.14 (P = 0.036), respectively. Dietary adherence was high on the basis of fatty acid changes in adipose tissue. CONCLUSIONS: Diet composition had no major effect on preventing weight regain. However, both the LF and MUFA diets produced less body fat regain than did the control diet, and the dropout rate was lowest in the LF diet group, whereas fasting insulin decreased and the homeostasis model assessment of insulin resistance and ratio of LDL to HDL improved with the MUFA diet. This trial was registered at clinicaltrials.gov as NCT00274729. ; Includes references ; p. 1232-1241.
language: eng
source:
identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 00029165
  • 0002-9165
url: Link


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titleComparison of 3 ad libitum diets for weight-loss maintenance, risk of cardiovascular disease, and diabetes: a 6-mo randomized, controlled trial
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subjectObesity-Related Diseases ; Diet ; Weight Loss ; Insulin ; Psoriasis ; Cardiovascular Diseases ; Obesity ; Body Mass Index ; Chronic Diseases ; Food Intake ; Insulin Resistance ; Women ; Cyclosporins ; Low Calorie Diet ; Dose Response ; Patients ; Noninsulin-Dependent Diabetes Mellitus ; Overweight ; Weight Control ; Drug Therapy ; Randomized Clinical Trials ; Nutritional Intervention ; Risk Factors ; Monounsaturated Fatty Acids ; Plaque Psoriasis
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