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Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime

The aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial... Full description

Journal Title: International journal of obesity : journal of the International Association for the Study of Obesity 2008, Vol.32(12), pp.1875-1878
Main Author: Mullerova , D.
Other Authors: Kopecky , J. , Matejkova , D. , Muller , L. , Rosmus , J. , Racek , J. , Sefrna , F. , Opatrna , S. , Kuda , O. , Matejovic , M.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0307-0565
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recordid: faoagrisUS201301592085
title: Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime
format: Article
creator:
  • Mullerova , D.
  • Kopecky , J.
  • Matejkova , D.
  • Muller , L.
  • Rosmus , J.
  • Racek , J.
  • Sefrna , F.
  • Opatrna , S.
  • Kuda , O.
  • Matejovic , M.
subjects:
  • Polychlorinated Biphenyls
  • Adiponectin
  • Blood Plasma
  • Obesity
  • Body Mass Index
  • Blood Chemistry
  • Nutritional Intervention
  • Energy Balance
  • Women
  • Longitudinal Studies
  • Low Calorie Diet
  • Polychlorinated Biphenyl 153
ispartof: International journal of obesity : journal of the International Association for the Study of Obesity, 2008, Vol.32(12), pp.1875-1878
description: The aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)>30 kg/m2; age 21-74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19-25 kg/m2; age 21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3+/-3.0 kg/m2. Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes. ; Includes references ; p. 1875-1878.
language: eng
source:
identifier: ISSN: 0307-0565
fulltext: fulltext
issn:
  • 03070565
  • 0307-0565
url: Link


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titleNegative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime
creatorMullerova , D. ; Kopecky , J. ; Matejkova , D. ; Muller , L. ; Rosmus , J. ; Racek , J. ; Sefrna , F. ; Opatrna , S. ; Kuda , O. ; Matejovic , M.
ispartofInternational journal of obesity : journal of the International Association for the Study of Obesity, 2008, Vol.32(12), pp.1875-1878
identifierISSN: 0307-0565
subjectPolychlorinated Biphenyls ; Adiponectin ; Blood Plasma ; Obesity ; Body Mass Index ; Blood Chemistry ; Nutritional Intervention ; Energy Balance ; Women ; Longitudinal Studies ; Low Calorie Diet ; Polychlorinated Biphenyl 153
descriptionThe aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)>30 kg/m2; age 21-74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19-25 kg/m2; age 21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3+/-3.0 kg/m2. Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes. ; Includes references ; p. 1875-1878.
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titleNegative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime
descriptionThe aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)>30 kg/m2; age 21-74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19-25 kg/m2; age 21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3+/-3.0 kg/m2. Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes. ; Includes references ; p. 1875-1878.
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titleNegative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime
authorMullerova , D. ; Kopecky , J. ; Matejkova , D. ; Muller , L. ; Rosmus , J. ; Racek , J. ; Sefrna , F. ; Opatrna , S. ; Kuda , O. ; Matejovic , M.
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10Low Calorie Diet
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abstractThe aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)>30 kg/m2; age 21-74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19-25 kg/m2; age 21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3+/-3.0 kg/m2. Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes.
doi10.1038/ijo.2008.169
eissn14765497