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Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans

Background: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass. Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether... Full description

Journal Title: International journal of obesity : journal of the International Association for the Study of Obesity 2009, Vol.33(11), p.1227–1234
Main Author: Grau , K.
Other Authors: Hansen , T. , Holst , C. , Astrup , A. , Saris , W.H.M. , Arner , P. , Rössner , S. , Macdonald , I. , Polak , J. , Oppert , J.M. , Langin , D. , Martinez , J.A. , Pedersen , O. , Sørensen , T.I.A.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Men
ID: ISSN: 0307-0565
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title: Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
format: Article
creator:
  • Grau , K.
  • Hansen , T.
  • Holst , C.
  • Astrup , A.
  • Saris , W.H.M.
  • Arner , P.
  • Rössner , S.
  • Macdonald , I.
  • Polak , J.
  • Oppert , J.M.
  • Langin , D.
  • Martinez , J.A.
  • Pedersen , O.
  • Sørensen , T.I.A.
subjects:
  • High Fat Diet
  • Fat Intake
  • Diet
  • Genes
  • Obesity
  • Low Carbohydrate Diet
  • Genotype
  • Gender Differences
  • Nutrient Intake
  • Body Composition
  • Nutrition-Genotype Interaction
  • Human Nutrition
  • Fat Free Mass
  • Diet-Related Diseases
  • Men
  • Nutritional Intervention
  • Randomized Clinical Trials
  • Body Weight
  • Resting Energy Expenditure
  • Alleles
  • Cohort Studies
  • Phenotype
  • Europeans
  • Insulin Resistance
  • Women
  • Experimental Diets
  • Lipid Peroxidation
  • Low Calorie Diet
  • Insulin Secretion
  • Carbohydrate Intake
  • Waist Circumference
  • Risk Factors
  • Fat Mass And Obesity-Associated (Fto)
  • Nugenob Study
ispartof: International journal of obesity : journal of the International Association for the Study of Obesity, 2009, Vol.33(11), p.1227–1234
description: Background: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass. Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content. Design: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20–25% of energy (%E) from fat, 60–65%E from CHO) or HF (40–45%E from fat, 40–45%E from CHO), hypo-energetic diet (measured resting metabolic rate multiplied by 1.3–600 kcal day-1). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-) and a surrogate measure of insulin resistance (HOMA-IR) were measured at baseline and after the intervention. In all, 764 individuals were genotyped for FTO rs9939609. Results: For A-allele carriers the drop-out rate was higher on HF than LF diet (in AT, P=0.002; in AT/AA combined, P=0.003). Among those individuals completing the intervention, we found no effect of FTO rs9939609 genotype on weight, FM, FFM, WC or FatOx. However, participants with TT had a smaller reduction in REE on LF than on HF diet (75 kcal/24 h; interaction: P=0.0055). These individuals also showed the greatest reduction in HOMA- and HOMA-IR (interaction: P=0.0083 and P=0.047). Conclusion: The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways; carriers of the A allele on LF diet appear to have a lower risk for drop out, and TT individuals have a smaller decrease in REE and greater decrease in HOMA- and HOMA-IR on LF than on HF diet. ; Includes references ; p. 1227–1234.
language: eng
source:
identifier: ISSN: 0307-0565
fulltext: fulltext
issn:
  • 03070565
  • 0307-0565
url: Link


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titleMacronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
creatorGrau , K. ; Hansen , T. ; Holst , C. ; Astrup , A. ; Saris , W.H.M. ; Arner , P. ; Rössner , S. ; Macdonald , I. ; Polak , J. ; Oppert , J.M. ; Langin , D. ; Martinez , J.A. ; Pedersen , O. ; Sørensen , T.I.A.
ispartofInternational journal of obesity : journal of the International Association for the Study of Obesity, 2009, Vol.33(11), p.1227–1234
identifierISSN: 0307-0565
subjectHigh Fat Diet ; Fat Intake ; Diet ; Genes ; Obesity ; Low Carbohydrate Diet ; Genotype ; Gender Differences ; Nutrient Intake ; Body Composition ; Nutrition-Genotype Interaction ; Human Nutrition ; Fat Free Mass ; Diet-Related Diseases ; Men ; Nutritional Intervention ; Randomized Clinical Trials ; Body Weight ; Resting Energy Expenditure ; Alleles ; Cohort Studies ; Phenotype ; Europeans ; Insulin Resistance ; Women ; Experimental Diets ; Lipid Peroxidation ; Low Calorie Diet ; Insulin Secretion ; Carbohydrate Intake ; Waist Circumference ; Risk Factors ; Fat Mass And Obesity-Associated (Fto) ; Nugenob Study
descriptionBackground: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass. Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content. Design: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20–25% of energy (%E) from fat, 60–65%E from CHO) or HF (40–45%E from fat, 40–45%E from CHO), hypo-energetic diet (measured resting metabolic rate multiplied by 1.3–600 kcal day-1). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-) and a surrogate measure of insulin resistance (HOMA-IR) were measured at baseline and after the intervention. In all, 764 individuals were genotyped for FTO rs9939609. Results: For A-allele carriers the drop-out rate was higher on HF than LF diet (in AT, P=0.002; in AT/AA combined, P=0.003). Among those individuals completing the intervention, we found no effect of FTO rs9939609 genotype on weight, FM, FFM, WC or FatOx. However, participants with TT had a smaller reduction in REE on LF than on HF diet (75 kcal/24 h; interaction: P=0.0055). These individuals also showed the greatest reduction in HOMA- and HOMA-IR (interaction: P=0.0083 and P=0.047). Conclusion: The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways; carriers of the A allele on LF diet appear to have a lower risk for drop out, and TT individuals have a smaller decrease in REE and greater decrease in HOMA- and HOMA-IR on LF than on HF diet. ; Includes references ; p. 1227–1234.
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8Polak , J.
9Oppert , J.M.
10Langin , D.
11Martinez , J.A.
12Pedersen , O.
13Sørensen , T.I.A.
titleMacronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
descriptionBackground: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass. Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content. Design: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20–25% of energy (%E) from fat, 60–65%E from CHO) or HF (40–45%E from fat, 40–45%E from CHO), hypo-energetic diet (measured resting metabolic rate multiplied by 1.3–600 kcal day-1). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-) and a surrogate measure of insulin resistance (HOMA-IR) were measured at baseline and after the intervention. In all, 764 individuals were genotyped for FTO rs9939609. Results: For A-allele carriers the drop-out rate was higher on HF than LF diet (in AT, P=0.002; in AT/AA combined, P=0.003). Among those individuals completing the intervention, we found no effect of FTO rs9939609 genotype on weight, FM, FFM, WC or FatOx. However, participants with TT had a smaller reduction in REE on LF than on HF diet (75 kcal/24 h; interaction: P=0.0055). These individuals also showed the greatest reduction in HOMA- and HOMA-IR (interaction: P=0.0083 and P=0.047). Conclusion: The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways; carriers of the A allele on LF diet appear to have a lower risk for drop out, and TT individuals have a smaller decrease in REE and greater decrease in HOMA- and HOMA-IR on LF than on HF diet. ; Includes references ; p. 1227–1234.
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30Waist Circumference
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titleMacronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans
authorGrau , K. ; Hansen , T. ; Holst , C. ; Astrup , A. ; Saris , W.H.M. ; Arner , P. ; Rössner , S. ; Macdonald , I. ; Polak , J. ; Oppert , J.M. ; Langin , D. ; Martinez , J.A. ; Pedersen , O. ; Sørensen , T.I.A.
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5Low Carbohydrate Diet
6Genotype
7Gender Differences
8Nutrient Intake
9Body Composition
10Nutrition-Genotype Interaction
11Human Nutrition
12Fat Free Mass
13Diet-Related Diseases
14Men
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16Randomized Clinical Trials
17Body Weight
18Resting Energy Expenditure
19Alleles
20Cohort Studies
21Phenotype
22Europeans
23Insulin Resistance
24Women
25Experimental Diets
26Lipid Peroxidation
27Low Calorie Diet
28Insulin Secretion
29Carbohydrate Intake
30Waist Circumference
31Risk Factors
32Fat Mass And Obesity-Associated (Fto)
33Nugenob Study
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1Hansen , T.
2Holst , C.
3Astrup , A.
4Saris , W.H.M.
5Arner , P.
6Rössner , S.
7Macdonald , I.
8Polak , J.
9Oppert , J.M.
10Langin , D.
11Martinez , J.A.
12Pedersen , O.
13Sørensen , T.I.A.
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1Hansen, T.
2Holst, C.
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6Rössner, S.
7Macdonald, I.
8Polak, J.
9Oppert, J.M.
10Langin, D.
11Martinez, J.A.
12Pedersen, O.
13Sørensen, T.I.A.
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abstractBackground: The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass. Objective: To examine whether FTO rs9939609 affects obese individuals' response to a high-fat, low-carbohydrate (CHO) (HF) or low-fat, high-CHO (LF), hypo-energetic diet and whether the effect of the FTO variant depends on dietary fat and CHO content. Design: In a 10-week, European, multi-centre dietary intervention study 771 obese women and men were randomized to either LF (20–25% of energy (%E) from fat, 60–65%E from CHO) or HF (40–45%E from fat, 40–45%E from CHO), hypo-energetic diet (measured resting metabolic rate multiplied by 1.3–600 kcal day-1). Body weight, fat mass (FM), fat-free mass (FFM), waist circumference (WC), resting energy expenditure (REE), fasting fat oxidation as % of REE (FatOx), insulin release (HOMA-) and a surrogate measure of insulin resistance (HOMA-IR) were measured at baseline and after the intervention. In all, 764 individuals were genotyped for FTO rs9939609. Results: For A-allele carriers the drop-out rate was higher on HF than LF diet (in AT, P=0.002; in AT/AA combined, P=0.003). Among those individuals completing the intervention, we found no effect of FTO rs9939609 genotype on weight, FM, FFM, WC or FatOx. However, participants with TT had a smaller reduction in REE on LF than on HF diet (75 kcal/24 h; interaction: P=0.0055). These individuals also showed the greatest reduction in HOMA- and HOMA-IR (interaction: P=0.0083 and P=0.047). Conclusion: The FTO rs9939609 may interact with the macronutrient composition in weight loss diets in various ways; carriers of the A allele on LF diet appear to have a lower risk for drop out, and TT individuals have a smaller decrease in REE and greater decrease in HOMA- and HOMA-IR on LF than on HF diet.
doi10.1038/ijo.2009.159
orcidid0000-0002-2669-7825
pages1227-12234
eissn14765497