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Modifications of abdominal fat and hepatic insulin clearance during severe caloric restriction

Using computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose... Full description

Journal Title: Annals of nutrition and metabolism 1990, Vol.34(6), pp.359-365
Main Author: Bosello , O.
Other Authors: Zamboni , M. , Armellini , F. , Zocca , I. , Bergamo Andreis , I.A. , Smacchia , C. , Milani , M.P. , Cominacini , L.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0250-6807
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recordid: faoagrisUS201301729160
title: Modifications of abdominal fat and hepatic insulin clearance during severe caloric restriction
format: Article
creator:
  • Bosello , O.
  • Zamboni , M.
  • Armellini , F.
  • Zocca , I.
  • Bergamo Andreis , I.A.
  • Smacchia , C.
  • Milani , M.P.
  • Cominacini , L.
subjects:
  • Tomography
  • Very Low Calorie Diet
  • Blood Glucose
  • Insulin
  • C-Peptide
  • Obesity
  • Body Mass Index
  • Abdominal Fat
  • Women
  • Body Weight
  • Low Calorie Diet
  • Lean Body Mass
ispartof: Annals of nutrition and metabolism, 1990, Vol.34(6), pp.359-365
description: Using computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose and insulin levels, oral glucose tolerance test, basal pancreatic insulin secretion estimated by fasting C peptide (Cp), and fasting insulin hepatic clearance calculated by Cp/insulin molar ratio. After VLCD the body weight and body mass index significantly declined (p < 0.01); whereas abdominal adipose tissue and visceral abdominal tissue (VAT) significantly decreased (p < 0.01), modifications of subcutaneus abdominal tissue (SAT) were not significant. Fasting insulin levels and plasma glucose response to oral glucose load significantly decreased (p < 0.05). Insulin response remained unchanged. Cp immunoreactive insulin (IRI) significantly increased (p < 0.01). A significant positive correlation was found between delta VAT and delta Cp/IRI before and after VLCD (p < 0.01). Our data seem to suggest that the weight loss induced by VLCD fundamentally involves a decrease in VAT. The reduction in visceral fat could be associated with an increase in hepatic insulin clearance. ; Includes 24 references. ; p. 359-365. charts.
language: eng
source:
identifier: ISSN: 0250-6807
fulltext: fulltext
issn:
  • 02506807
  • 0250-6807
url: Link


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titleModifications of abdominal fat and hepatic insulin clearance during severe caloric restriction
creatorBosello , O. ; Zamboni , M. ; Armellini , F. ; Zocca , I. ; Bergamo Andreis , I.A. ; Smacchia , C. ; Milani , M.P. ; Cominacini , L.
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identifierISSN: 0250-6807
subjectTomography ; Very Low Calorie Diet ; Blood Glucose ; Insulin ; C-Peptide ; Obesity ; Body Mass Index ; Abdominal Fat ; Women ; Body Weight ; Low Calorie Diet ; Lean Body Mass
descriptionUsing computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose and insulin levels, oral glucose tolerance test, basal pancreatic insulin secretion estimated by fasting C peptide (Cp), and fasting insulin hepatic clearance calculated by Cp/insulin molar ratio. After VLCD the body weight and body mass index significantly declined (p < 0.01); whereas abdominal adipose tissue and visceral abdominal tissue (VAT) significantly decreased (p < 0.01), modifications of subcutaneus abdominal tissue (SAT) were not significant. Fasting insulin levels and plasma glucose response to oral glucose load significantly decreased (p < 0.05). Insulin response remained unchanged. Cp immunoreactive insulin (IRI) significantly increased (p < 0.01). A significant positive correlation was found between delta VAT and delta Cp/IRI before and after VLCD (p < 0.01). Our data seem to suggest that the weight loss induced by VLCD fundamentally involves a decrease in VAT. The reduction in visceral fat could be associated with an increase in hepatic insulin clearance. ; Includes 24 references. ; p. 359-365. charts.
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titleModifications of abdominal fat and hepatic insulin clearance during severe caloric restriction
descriptionUsing computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose and insulin levels, oral glucose tolerance test, basal pancreatic insulin secretion estimated by fasting C peptide (Cp), and fasting insulin hepatic clearance calculated by Cp/insulin molar ratio. After VLCD the body weight and body mass index significantly declined (p < 0.01); whereas abdominal adipose tissue and visceral abdominal tissue (VAT) significantly decreased (p < 0.01), modifications of subcutaneus abdominal tissue (SAT) were not significant. Fasting insulin levels and plasma glucose response to oral glucose load significantly decreased (p < 0.05). Insulin response remained unchanged. Cp immunoreactive insulin (IRI) significantly increased (p < 0.01). A significant positive correlation was found between delta VAT and delta Cp/IRI before and after VLCD (p < 0.01). Our data seem to suggest that the weight loss induced by VLCD fundamentally involves a decrease in VAT. The reduction in visceral fat could be associated with an increase in hepatic insulin clearance. ; Includes 24 references. ; p. 359-365. charts.
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notesIncludes 24 references.
abstractUsing computed tomography on 19 obese female subjects, we determined abdominal adipose tissue, both subcutaneous and visceral adipose tissue, before and after 2 weeks of a very low caloric diet (VLCD). The following parameters were also determined before and after 15-20 days of VLCD: plasma glucose and insulin levels, oral glucose tolerance test, basal pancreatic insulin secretion estimated by fasting C peptide (Cp), and fasting insulin hepatic clearance calculated by Cp/insulin molar ratio. After VLCD the body weight and body mass index significantly declined (p < 0.01); whereas abdominal adipose tissue and visceral abdominal tissue (VAT) significantly decreased (p < 0.01), modifications of subcutaneus abdominal tissue (SAT) were not significant. Fasting insulin levels and plasma glucose response to oral glucose load significantly decreased (p < 0.05). Insulin response remained unchanged. Cp immunoreactive insulin (IRI) significantly increased (p < 0.01). A significant positive correlation was found between delta VAT and delta Cp/IRI before and after VLCD (p < 0.01). Our data seem to suggest that the weight loss induced by VLCD fundamentally involves a decrease in VAT. The reduction in visceral fat could be associated with an increase in hepatic insulin clearance.
doi10.1159/000177610
eissn14219697