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Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis

BACKGROUND: Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic colonic inflammation induces CRC. OBJECTIVE: We conducted this proof-of-principle study to seek evidenc... Full description

Journal Title: American journal of clinical nutrition 2011, Vol.93(2), pp.234-242
Main Author: Pendyala , Swaroop
Other Authors: Neff , Lisa M. , Suárez-Fariñas , Mayte , Holt , Peter R.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-9165
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recordid: faoagrisUS201301933772
title: Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis
format: Article
creator:
  • Pendyala , Swaroop
  • Neff , Lisa M.
  • Suárez-Fariñas , Mayte
  • Holt , Peter R.
subjects:
  • Cytokines
  • Diet
  • Genes
  • Menopause
  • Obesity
  • Tumor Necrosis Factor-Alpha
  • Low Density Lipoprotein
  • Carcinogenesis
  • Prostaglandins
  • Human Nutrition
  • T-Lymphocytes
  • Diet-Related Diseases
  • Macrophages
  • Chemokines
  • Interleukin-1
  • Biochemical Pathways
  • Inflammation
  • Weight Loss
  • Blood Glucose
  • Transcription Factors
  • Colorectal Neoplasms
  • Blood Lipids
  • Women
  • Cholesterol
  • Oxidative Stress
  • Interleukin-8
  • Very Low Calorie Diet
  • Intestinal Mucosa
  • Human Diseases
  • Gene Expression
  • Triacylglycerols
  • Monocyte Chemotactic Protein 1
ispartof: American journal of clinical nutrition, 2011, Vol.93(2), pp.234-242
description: BACKGROUND: Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic colonic inflammation induces CRC. OBJECTIVE: We conducted this proof-of-principle study to seek evidence of obesity-associated colorectal inflammation and to evaluate effects of diet-induced weight loss. DESIGN: We measured inflammatory cytokines, gene arrays, and macrophage infiltration in rectosigmoid mucosal biopsies of 10 obese premenopausal women [mean ± SD body mass index (in kg/m²): 35 ± 3.5] before and after weight loss induced by a very-low-calorie diet. RESULTS: Subjects lost a mean (±SD) of 10.1 ± 1% of their initial weight. Weight loss significantly reduced fasting blood glucose, total cholesterol, triglycerides, LDL, tumor necrosis factor-α (TNF-α), and interleukin (IL)-8 concentrations (P < 0.05). After weight loss, rectosigmoid biopsies showed a 25-57% reduction in TNF-α, IL-1β, IL-8, and monocyte chemotactic protein 1 concentrations (P < 0.05). T cell and macrophage counts decreased by 28% and 42%, respectively (P < 0.05). Gene arrays showed dramatic down-regulation of proinflammatory cytokine and chemokine pathways, prostaglandin metabolism, and the transcription factors STAT3 (signal transducer and activator of transcription 3) and nuclear transcription factor κB. Weight loss reduced expression of FOS and JUN genes and down-regulated oxidative stress pathways and the transcription factors ATF (activating transcription factor) and CREB (cyclic AMP response element-binding). CONCLUSIONS: Our data show that diet-induced weight loss in obese individuals reduces colorectal inflammation and greatly modulates inflammatory and cancer-related gene pathways. These data imply that obesity is accompanied by inflammation in the colorectal mucosa and that diet-induced weight loss reduces this inflammatory state and may thereby lower CRC risk. ; Includes references ; p. 234-242.
language: eng
source:
identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 00029165
  • 0002-9165
url: Link


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titleDiet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis
creatorPendyala , Swaroop ; Neff , Lisa M. ; Suárez-Fariñas , Mayte ; Holt , Peter R.
ispartofAmerican journal of clinical nutrition, 2011, Vol.93(2), pp.234-242
identifierISSN: 0002-9165
subjectCytokines ; Diet ; Genes ; Menopause ; Obesity ; Tumor Necrosis Factor-Alpha ; Low Density Lipoprotein ; Carcinogenesis ; Prostaglandins ; Human Nutrition ; T-Lymphocytes ; Diet-Related Diseases ; Macrophages ; Chemokines ; Interleukin-1 ; Biochemical Pathways ; Inflammation ; Weight Loss ; Blood Glucose ; Transcription Factors ; Colorectal Neoplasms ; Blood Lipids ; Women ; Cholesterol ; Oxidative Stress ; Interleukin-8 ; Very Low Calorie Diet ; Intestinal Mucosa ; Human Diseases ; Gene Expression ; Triacylglycerols ; Monocyte Chemotactic Protein 1
descriptionBACKGROUND: Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic colonic inflammation induces CRC. OBJECTIVE: We conducted this proof-of-principle study to seek evidence of obesity-associated colorectal inflammation and to evaluate effects of diet-induced weight loss. DESIGN: We measured inflammatory cytokines, gene arrays, and macrophage infiltration in rectosigmoid mucosal biopsies of 10 obese premenopausal women [mean ± SD body mass index (in kg/m²): 35 ± 3.5] before and after weight loss induced by a very-low-calorie diet. RESULTS: Subjects lost a mean (±SD) of 10.1 ± 1% of their initial weight. Weight loss significantly reduced fasting blood glucose, total cholesterol, triglycerides, LDL, tumor necrosis factor-α (TNF-α), and interleukin (IL)-8 concentrations (P < 0.05). After weight loss, rectosigmoid biopsies showed a 25-57% reduction in TNF-α, IL-1β, IL-8, and monocyte chemotactic protein 1 concentrations (P < 0.05). T cell and macrophage counts decreased by 28% and 42%, respectively (P < 0.05). Gene arrays showed dramatic down-regulation of proinflammatory cytokine and chemokine pathways, prostaglandin metabolism, and the transcription factors STAT3 (signal transducer and activator of transcription 3) and nuclear transcription factor κB. Weight loss reduced expression of FOS and JUN genes and down-regulated oxidative stress pathways and the transcription factors ATF (activating transcription factor) and CREB (cyclic AMP response element-binding). CONCLUSIONS: Our data show that diet-induced weight loss in obese individuals reduces colorectal inflammation and greatly modulates inflammatory and cancer-related gene pathways. These data imply that obesity is accompanied by inflammation in the colorectal mucosa and that diet-induced weight loss reduces this inflammatory state and may thereby lower CRC risk. ; Includes references ; p. 234-242.
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titleDiet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis
descriptionBACKGROUND: Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic colonic inflammation induces CRC. OBJECTIVE: We conducted this proof-of-principle study to seek evidence of obesity-associated colorectal inflammation and to evaluate effects of diet-induced weight loss. DESIGN: We measured inflammatory cytokines, gene arrays, and macrophage infiltration in rectosigmoid mucosal biopsies of 10 obese premenopausal women [mean ± SD body mass index (in kg/m²): 35 ± 3.5] before and after weight loss induced by a very-low-calorie diet. RESULTS: Subjects lost a mean (±SD) of 10.1 ± 1% of their initial weight. Weight loss significantly reduced fasting blood glucose, total cholesterol, triglycerides, LDL, tumor necrosis factor-α (TNF-α), and interleukin (IL)-8 concentrations (P < 0.05). After weight loss, rectosigmoid biopsies showed a 25-57% reduction in TNF-α, IL-1β, IL-8, and monocyte chemotactic protein 1 concentrations (P < 0.05). T cell and macrophage counts decreased by 28% and 42%, respectively (P < 0.05). Gene arrays showed dramatic down-regulation of proinflammatory cytokine and chemokine pathways, prostaglandin metabolism, and the transcription factors STAT3 (signal transducer and activator of transcription 3) and nuclear transcription factor κB. Weight loss reduced expression of FOS and JUN genes and down-regulated oxidative stress pathways and the transcription factors ATF (activating transcription factor) and CREB (cyclic AMP response element-binding). CONCLUSIONS: Our data show that diet-induced weight loss in obese individuals reduces colorectal inflammation and greatly modulates inflammatory and cancer-related gene pathways. These data imply that obesity is accompanied by inflammation in the colorectal mucosa and that diet-induced weight loss reduces this inflammatory state and may thereby lower CRC risk. ; Includes references ; p. 234-242.
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abstractBACKGROUND: Epidemiologic data have shown that obesity independently increases colorectal cancer (CRC) risk, but the mechanisms are poorly understood. Obesity is an inflammatory state, and chronic colonic inflammation induces CRC. OBJECTIVE: We conducted this proof-of-principle study to seek evidence of obesity-associated colorectal inflammation and to evaluate effects of diet-induced weight loss. DESIGN: We measured inflammatory cytokines, gene arrays, and macrophage infiltration in rectosigmoid mucosal biopsies of 10 obese premenopausal women [mean ± SD body mass index (in kg/m²): 35 ± 3.5] before and after weight loss induced by a very-low-calorie diet. RESULTS: Subjects lost a mean (±SD) of 10.1 ± 1% of their initial weight. Weight loss significantly reduced fasting blood glucose, total cholesterol, triglycerides, LDL, tumor necrosis factor-α (TNF-α), and interleukin (IL)-8 concentrations (P < 0.05). After weight loss, rectosigmoid biopsies showed a 25-57% reduction in TNF-α, IL-1β, IL-8, and monocyte chemotactic protein 1 concentrations (P < 0.05). T cell and macrophage counts decreased by 28% and 42%, respectively (P < 0.05). Gene arrays showed dramatic down-regulation of proinflammatory cytokine and chemokine pathways, prostaglandin metabolism, and the transcription factors STAT3 (signal transducer and activator of transcription 3) and nuclear transcription factor κB. Weight loss reduced expression of FOS and JUN genes and down-regulated oxidative stress pathways and the transcription factors ATF (activating transcription factor) and CREB (cyclic AMP response element-binding). CONCLUSIONS: Our data show that diet-induced weight loss in obese individuals reduces colorectal inflammation and greatly modulates inflammatory and cancer-related gene pathways. These data imply that obesity is accompanied by inflammation in the colorectal mucosa and that diet-induced weight loss reduces this inflammatory state and may thereby lower CRC risk.
pubAmerican Society for Clinical Nutrition
doi10.3945/ajcn.110.002683
eissn19383207
date2011-02-01