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Effects of necrotic enteritis challenge on intestinal micro-architecture and mucin profile

1. This study investigated the effect of Eimeria spp./Clostridium perfringens induced necrotic enteritis and traditional antibiotic preventatives on intestinal micro-architecture and mucin profile.2. A total of 600 Cobb 500 broiler chickens were randomly assigned to the following three groups: (i) u... Full description

Journal Title: British poultry science 2011, Vol.52(4), pp.500-506
Main Author: Golder , H.M.
Other Authors: Geier , M.S. , Forder , R.E.A. , Hynd , P.I. , Hughes , R.J.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1466-1799
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recordid: faoagrisUS201400122047
title: Effects of necrotic enteritis challenge on intestinal micro-architecture and mucin profile
format: Article
creator:
  • Golder , H.M.
  • Geier , M.S.
  • Forder , R.E.A.
  • Hynd , P.I.
  • Hughes , R.J.
subjects:
  • Zinc
  • Arachis Hypogaea
  • Necrotic Enteritis
  • Broiler Chickens
  • Mucins
  • Bacitracin
  • Monensin
  • Eimeria Acervulina
  • Lectins
  • Villi
ispartof: British poultry science, 2011, Vol.52(4), pp.500-506
description: 1. This study investigated the effect of Eimeria spp./Clostridium perfringens induced necrotic enteritis and traditional antibiotic preventatives on intestinal micro-architecture and mucin profile.2. A total of 600 Cobb 500 broiler chickens were randomly assigned to the following three groups: (i) unchallenged, (ii) challenged, and (iii) zinc bacitracin/monensin (ZnB/monensin) (n = 25 chickens/pen, 8 pens/group). The challenged and ZnB/monensin chickens were individually inoculated with Eimeria acervulina, E. maxima and E. tenella and C. perfringens type A (EHE-NE18) at 9 and 15 d post-hatch respectively, to induce necrotic enteritis.3. The challenge procedure significantly decreased villus height, increased villus width and increased crypt depth in the challenged compared to the unchallenged chickens. Zinc bacitracin and monensin maintained villus-crypt structure similar to that of the unchallenged chickens.4. Mucin profile was not affected by Eimeria spp./C. perfringens challenge as demonstrated by periodic acid-Schiff and high iron diamine-alcian blue pH 2·5 staining. Zinc bacitracin and monensin decreased the number of intestinal mucin-containing goblet cells.5. Lectin histochemistry showed a trend towards greater Arachis hypogea (PNA) reactivity in unchallenged chickens.6. In summary, Eimeria spp./C. perfringens challenge disrupted intestinal micro-architecture; however, challenge did not appear to affect intestinal mucin profile. Traditional antibiotics, zinc bacitracin and monensin maintained micro-architecture. ; p. 500-506.
language: eng
source:
identifier: ISSN: 1466-1799
fulltext: fulltext
issn:
  • 14661799
  • 1466-1799
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titleEffects of necrotic enteritis challenge on intestinal micro-architecture and mucin profile
creatorGolder , H.M. ; Geier , M.S. ; Forder , R.E.A. ; Hynd , P.I. ; Hughes , R.J.
ispartofBritish poultry science, 2011, Vol.52(4), pp.500-506
identifierISSN: 1466-1799
subjectZinc ; Arachis Hypogaea ; Necrotic Enteritis ; Broiler Chickens ; Mucins ; Bacitracin ; Monensin ; Eimeria Acervulina ; Lectins ; Villi
description1. This study investigated the effect of Eimeria spp./Clostridium perfringens induced necrotic enteritis and traditional antibiotic preventatives on intestinal micro-architecture and mucin profile.2. A total of 600 Cobb 500 broiler chickens were randomly assigned to the following three groups: (i) unchallenged, (ii) challenged, and (iii) zinc bacitracin/monensin (ZnB/monensin) (n = 25 chickens/pen, 8 pens/group). The challenged and ZnB/monensin chickens were individually inoculated with Eimeria acervulina, E. maxima and E. tenella and C. perfringens type A (EHE-NE18) at 9 and 15 d post-hatch respectively, to induce necrotic enteritis.3. The challenge procedure significantly decreased villus height, increased villus width and increased crypt depth in the challenged compared to the unchallenged chickens. Zinc bacitracin and monensin maintained villus-crypt structure similar to that of the unchallenged chickens.4. Mucin profile was not affected by Eimeria spp./C. perfringens challenge as demonstrated by periodic acid-Schiff and high iron diamine-alcian blue pH 2·5 staining. Zinc bacitracin and monensin decreased the number of intestinal mucin-containing goblet cells.5. Lectin histochemistry showed a trend towards greater Arachis hypogea (PNA) reactivity in unchallenged chickens.6. In summary, Eimeria spp./C. perfringens challenge disrupted intestinal micro-architecture; however, challenge did not appear to affect intestinal mucin profile. Traditional antibiotics, zinc bacitracin and monensin maintained micro-architecture. ; p. 500-506.
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titleEffects of necrotic enteritis challenge on intestinal micro-architecture and mucin profile
description1. This study investigated the effect of Eimeria spp./Clostridium perfringens induced necrotic enteritis and traditional antibiotic preventatives on intestinal micro-architecture and mucin profile.2. A total of 600 Cobb 500 broiler chickens were randomly assigned to the following three groups: (i) unchallenged, (ii) challenged, and (iii) zinc bacitracin/monensin (ZnB/monensin) (n = 25 chickens/pen, 8 pens/group). The challenged and ZnB/monensin chickens were individually inoculated with Eimeria acervulina, E. maxima and E. tenella and C. perfringens type A (EHE-NE18) at 9 and 15 d post-hatch respectively, to induce necrotic enteritis.3. The challenge procedure significantly decreased villus height, increased villus width and increased crypt depth in the challenged compared to the unchallenged chickens. Zinc bacitracin and monensin maintained villus-crypt structure similar to that of the unchallenged chickens.4. Mucin profile was not affected by Eimeria spp./C. perfringens challenge as demonstrated by periodic acid-Schiff and high iron diamine-alcian blue pH 2·5 staining. Zinc bacitracin and monensin decreased the number of intestinal mucin-containing goblet cells.5. Lectin histochemistry showed a trend towards greater Arachis hypogea (PNA) reactivity in unchallenged chickens.6. In summary, Eimeria spp./C. perfringens challenge disrupted intestinal micro-architecture; however, challenge did not appear to affect intestinal mucin profile. Traditional antibiotics, zinc bacitracin and monensin maintained micro-architecture. ; p. 500-506.
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abstract1. This study investigated the effect of Eimeria spp./Clostridium perfringens induced necrotic enteritis and traditional antibiotic preventatives on intestinal micro-architecture and mucin profile.2. A total of 600 Cobb 500 broiler chickens were randomly assigned to the following three groups: (i) unchallenged, (ii) challenged, and (iii) zinc bacitracin/monensin (ZnB/monensin) (n = 25 chickens/pen, 8 pens/group). The challenged and ZnB/monensin chickens were individually inoculated with Eimeria acervulina, E. maxima and E. tenella and C. perfringens type A (EHE-NE18) at 9 and 15 d post-hatch respectively, to induce necrotic enteritis.3. The challenge procedure significantly decreased villus height, increased villus width and increased crypt depth in the challenged compared to the unchallenged chickens. Zinc bacitracin and monensin maintained villus-crypt structure similar to that of the unchallenged chickens.4. Mucin profile was not affected by Eimeria spp./C. perfringens challenge as demonstrated by periodic acid-Schiff and high iron diamine-alcian blue pH 2·5 staining. Zinc bacitracin and monensin decreased the number of intestinal mucin-containing goblet cells.5. Lectin histochemistry showed a trend towards greater Arachis hypogea (PNA) reactivity in unchallenged chickens.6. In summary, Eimeria spp./C. perfringens challenge disrupted intestinal micro-architecture; however, challenge did not appear to affect intestinal mucin profile. Traditional antibiotics, zinc bacitracin and monensin maintained micro-architecture.
pubTaylor & Francis Group
doi10.1080/00071668.2011.587183