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Neonatal outcomes of intrauterine nonylphenol exposure—A longitudinal cohort study in Taiwan

BACKGROUND: Nonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intraute... Full description

Journal Title: Science of the total environment 2013, Vol.458, pp.367-373
Main Author: Tsai , Ming-Song
Other Authors: Chang , Chia-Huang , Tsai , Yen-An , Liao , Kai-Wei , Mao , I-Fang , Wang , Tzu-Hao , Hwang , Shiaw-Min , Chang , Yu-Jen , Chen , Mei-Lien
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: AGRIS (Food and Agriculture Organization of the United Nations)
ID: ISSN: 0048-9697
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recordid: faoagrisUS201400175752
title: Neonatal outcomes of intrauterine nonylphenol exposure—A longitudinal cohort study in Taiwan
format: Article
creator:
  • Tsai , Ming-Song
  • Chang , Chia-Huang
  • Tsai , Yen-An
  • Liao , Kai-Wei
  • Mao , I-Fang
  • Wang , Tzu-Hao
  • Hwang , Shiaw-Min
  • Chang , Yu-Jen
  • Chen , Mei-Lien
subjects:
  • Small For Gestational Age
  • Estrogenic Properties
  • Pregnant Women
  • Gestational Age
  • Humans
  • Urine
  • Adverse Effects
  • Odds Ratio
  • Pregnancy
  • Body Length
  • Neonates
  • Parturition
  • Weight Gain
  • High Performance Liquid Chromatography
  • Regression Analysis
  • Longitudinal Studies
ispartof: Science of the total environment, 2013, Vol.458, pp.367-373
description: BACKGROUND: Nonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intrauterine NP exposure on neonates. METHODS: A cohort of pregnant women was established in a medical centre in northern Taiwan. Urine samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. Neonatal outcomes were evaluated immediately after delivery. A mixed-effects model using a generalised estimating equation was applied to assess the association between gestational age, maternal body weight, and maternal NP concentration throughout the three trimesters. A multivariable regression model was used to determine the association between maternal NP level in urine in each trimester and neonatal outcomes. RESULTS: In total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27μg/g, 4.21μg/g, and 4.10μg/g in the first, second, and third trimesters, respectively. Pregnant women whose urinary NP concentrations were above the median in the second trimester had low maternal weight gain (β=−1.55kg, p=0.02) and short neonatal body length (β=−0.47cm, p=0.04). Women with an above-median urinary NP concentration had an odds ratio of having a small for gestational age (SGA) neonate of 7.81 (p
language: eng
source: AGRIS (Food and Agriculture Organization of the United Nations)
identifier: ISSN: 0048-9697
fulltext: fulltext
issn:
  • 00489697
  • 0048-9697
url: Link


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titleNeonatal outcomes of intrauterine nonylphenol exposure—A longitudinal cohort study in Taiwan
creatorTsai , Ming-Song ; Chang , Chia-Huang ; Tsai , Yen-An ; Liao , Kai-Wei ; Mao , I-Fang ; Wang , Tzu-Hao ; Hwang , Shiaw-Min ; Chang , Yu-Jen ; Chen , Mei-Lien
ispartofScience of the total environment, 2013, Vol.458, pp.367-373
identifierISSN: 0048-9697
subjectSmall For Gestational Age ; Estrogenic Properties ; Pregnant Women ; Gestational Age ; Humans ; Urine ; Adverse Effects ; Odds Ratio ; Pregnancy ; Body Length ; Neonates ; Parturition ; Weight Gain ; High Performance Liquid Chromatography ; Regression Analysis ; Longitudinal Studies
descriptionBACKGROUND: Nonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intrauterine NP exposure on neonates. METHODS: A cohort of pregnant women was established in a medical centre in northern Taiwan. Urine samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. Neonatal outcomes were evaluated immediately after delivery. A mixed-effects model using a generalised estimating equation was applied to assess the association between gestational age, maternal body weight, and maternal NP concentration throughout the three trimesters. A multivariable regression model was used to determine the association between maternal NP level in urine in each trimester and neonatal outcomes. RESULTS: In total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27μg/g, 4.21μg/g, and 4.10μg/g in the first, second, and third trimesters, respectively. Pregnant women whose urinary NP concentrations were above the median in the second trimester had low maternal weight gain (β=−1.55kg, p=0.02) and short neonatal body length (β=−0.47cm, p=0.04). Women with an above-median urinary NP concentration had an odds ratio of having a small for gestational age (SGA) neonate of 7.81 (p<0.05). CONCLUSIONS: This study indicates that maternal high NP exposure in the second trimester is associated with SGA, decreased foetal body length at birth, and low maternal weight gain. The effects of this endocrine-disrupting substance on pregnant women and foetuses should be a concern during gestation. ; p. 367-373.
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titleNeonatal outcomes of intrauterine nonylphenol exposure—A longitudinal cohort study in Taiwan
descriptionBACKGROUND: Nonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intrauterine NP exposure on neonates. METHODS: A cohort of pregnant women was established in a medical centre in northern Taiwan. Urine samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. Neonatal outcomes were evaluated immediately after delivery. A mixed-effects model using a generalised estimating equation was applied to assess the association between gestational age, maternal body weight, and maternal NP concentration throughout the three trimesters. A multivariable regression model was used to determine the association between maternal NP level in urine in each trimester and neonatal outcomes. RESULTS: In total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27μg/g, 4.21μg/g, and 4.10μg/g in the first, second, and third trimesters, respectively. Pregnant women whose urinary NP concentrations were above the median in the second trimester had low maternal weight gain (β=−1.55kg, p=0.02) and short neonatal body length (β=−0.47cm, p=0.04). Women with an above-median urinary NP concentration had an odds ratio of having a small for gestational age (SGA) neonate of 7.81 (p<0.05). CONCLUSIONS: This study indicates that maternal high NP exposure in the second trimester is associated with SGA, decreased foetal body length at birth, and low maternal weight gain. The effects of this endocrine-disrupting substance on pregnant women and foetuses should be a concern during gestation. ; p. 367-373.
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authorTsai , Ming-Song ; Chang , Chia-Huang ; Tsai , Yen-An ; Liao , Kai-Wei ; Mao , I-Fang ; Wang , Tzu-Hao ; Hwang , Shiaw-Min ; Chang , Yu-Jen ; Chen , Mei-Lien
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abstractBACKGROUND: Nonylphenol (NP) is an environmental hormone with proven estrogenic effects. Although its adverse effects on animals are well documented, the effects of NP exposure on humans remain unclear, and those on the human foetus are completely unknown. This study explores the effects of intrauterine NP exposure on neonates. METHODS: A cohort of pregnant women was established in a medical centre in northern Taiwan. Urine samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. Neonatal outcomes were evaluated immediately after delivery. A mixed-effects model using a generalised estimating equation was applied to assess the association between gestational age, maternal body weight, and maternal NP concentration throughout the three trimesters. A multivariable regression model was used to determine the association between maternal NP level in urine in each trimester and neonatal outcomes. RESULTS: In total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27μg/g, 4.21μg/g, and 4.10μg/g in the first, second, and third trimesters, respectively. Pregnant women whose urinary NP concentrations were above the median in the second trimester had low maternal weight gain (β=−1.55kg, p=0.02) and short neonatal body length (β=−0.47cm, p=0.04). Women with an above-median urinary NP concentration had an odds ratio of having a small for gestational age (SGA) neonate of 7.81 (p<0.05). CONCLUSIONS: This study indicates that maternal high NP exposure in the second trimester is associated with SGA, decreased foetal body length at birth, and low maternal weight gain. The effects of this endocrine-disrupting substance on pregnant women and foetuses should be a concern during gestation.
pubElsevier B.V.