schliessen

Filtern

 

Bibliotheken

Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes

Background: Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids (NEFAs) raise plasma ANGPTL4 concentrations in humans.Objective: The objective was to assess plasma ANGPTL4 concentrations after... Full description

Journal Title: American journal of clinical nutrition 2013, Vol.97(2), pp.255-260
Main Author: Jonker , Jacqueline T
Other Authors: Smit , Johannes Wa , Hammer , Sebastiaan , Snel , Marieke , Van Der Meer , Rutger W , Lamb , Hildo J , Mattijssen , Frits , Mudde , Karin , Jazet , Ingrid M , Dekkers , Olaf M , De Roos , Albert , Romijn , Johannes A , Kersten , Sander , Rensen , Patrick Cn
Format: Electronic Article Electronic Article
Language: English
Subjects:
Men
ID: ISSN: 0002-9165
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: faoagrisUS201500150598
title: Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
format: Article
creator:
  • Jonker , Jacqueline T
  • Smit , Johannes Wa
  • Hammer , Sebastiaan
  • Snel , Marieke
  • Van Der Meer , Rutger W
  • Lamb , Hildo J
  • Mattijssen , Frits
  • Mudde , Karin
  • Jazet , Ingrid M
  • Dekkers , Olaf M
  • De Roos , Albert
  • Romijn , Johannes A
  • Kersten , Sander
  • Rensen , Patrick Cn
subjects:
  • Lipoprotein Lipase
  • Free Fatty Acids
  • Very Low Calorie Diet
  • Patients
  • Noninsulin-Dependent Diabetes Mellitus
  • Clinical Nutrition
  • Volunteers
  • Fasting
  • Correlation
  • Men
  • High Energy Diet
  • Triacylglycerols
ispartof: American journal of clinical nutrition, 2013, Vol.97(2), pp.255-260
description: Background: Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids (NEFAs) raise plasma ANGPTL4 concentrations in humans.Objective: The objective was to assess plasma ANGPTL4 concentrations after various nutritional interventions that increase NEFA concentrations in healthy subjects and in patients with type 2 diabetes mellitus.Design: We studied 4 groups, both at baseline and after 3 d of either fasting (n = 22 healthy men), a very-low-calorie diet (VLCD; n = 10 healthy men and n = 10 patients with diabetes), or a high-fat, high-energy diet (HFED; n = 15 healthy men). Plasma ANGPTL4, NEFA, and triglyceride concentrations were measured.Results: In healthy men, a VLCD increased ANGPTL4 from 13.2 (IQR: 8.1–24.2) at baseline to 18.2 (16.7–33.4) ng/mL (P < 0.05), fasting increased ANGPTL4 from 10.6 (7.6–17.6) to 28.0 (23.1–35.0) ng/mL (P < 0.05), and an HFED increased ANGPTL4 from 13.9 (8.2–22.0) to 17.2 (11.2–23.6) ng/mL (P < 0.05). In men with diabetes, a VLCD also increased ANGPTL4, from 10.9 ± 2.4 to 19.2 ± 3.2 ng/mL (P < 0.05). All interventions significantly increased plasma NEFAs in both healthy men and patients with diabetes. The change in ANGPTL4 positively correlated with the change in NEFA concentrations (β = 0.048, P < 0.001) and negatively correlated with the change in plasma triglycerides (β = −0.051, P = 0.01).Conclusions: Three days of either fasting, a VLCD, or an HFED increased plasma ANGPTL4 concentrations in healthy men, concomitantly with increased plasma NEFA concentrations. Similarly, a VLCD in patients with diabetes increased ANGPTL4 concentrations, concomitantly with increased NEFA concentrations. ; p. 255-260.
language: eng
source:
identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 00029165
  • 0002-9165
url: Link


@attributes
ID1568601120
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordidUS201500150598
sourceidfaoagris
recordidTN_faoagrisUS201500150598
sourcesystemOther
pqid1273697465
galeid317074529
display
typearticle
titleDietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
creatorJonker , Jacqueline T ; Smit , Johannes Wa ; Hammer , Sebastiaan ; Snel , Marieke ; Van Der Meer , Rutger W ; Lamb , Hildo J ; Mattijssen , Frits ; Mudde , Karin ; Jazet , Ingrid M ; Dekkers , Olaf M ; De Roos , Albert ; Romijn , Johannes A ; Kersten , Sander ; Rensen , Patrick Cn
ispartofAmerican journal of clinical nutrition, 2013, Vol.97(2), pp.255-260
identifierISSN: 0002-9165
subjectLipoprotein Lipase ; Free Fatty Acids ; Very Low Calorie Diet ; Patients ; Noninsulin-Dependent Diabetes Mellitus ; Clinical Nutrition ; Volunteers ; Fasting ; Correlation ; Men ; High Energy Diet ; Triacylglycerols
descriptionBackground: Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids (NEFAs) raise plasma ANGPTL4 concentrations in humans.Objective: The objective was to assess plasma ANGPTL4 concentrations after various nutritional interventions that increase NEFA concentrations in healthy subjects and in patients with type 2 diabetes mellitus.Design: We studied 4 groups, both at baseline and after 3 d of either fasting (n = 22 healthy men), a very-low-calorie diet (VLCD; n = 10 healthy men and n = 10 patients with diabetes), or a high-fat, high-energy diet (HFED; n = 15 healthy men). Plasma ANGPTL4, NEFA, and triglyceride concentrations were measured.Results: In healthy men, a VLCD increased ANGPTL4 from 13.2 (IQR: 8.1–24.2) at baseline to 18.2 (16.7–33.4) ng/mL (P < 0.05), fasting increased ANGPTL4 from 10.6 (7.6–17.6) to 28.0 (23.1–35.0) ng/mL (P < 0.05), and an HFED increased ANGPTL4 from 13.9 (8.2–22.0) to 17.2 (11.2–23.6) ng/mL (P < 0.05). In men with diabetes, a VLCD also increased ANGPTL4, from 10.9 ± 2.4 to 19.2 ± 3.2 ng/mL (P < 0.05). All interventions significantly increased plasma NEFAs in both healthy men and patients with diabetes. The change in ANGPTL4 positively correlated with the change in NEFA concentrations (β = 0.048, P < 0.001) and negatively correlated with the change in plasma triglycerides (β = −0.051, P = 0.01).Conclusions: Three days of either fasting, a VLCD, or an HFED increased plasma ANGPTL4 concentrations in healthy men, concomitantly with increased plasma NEFA concentrations. Similarly, a VLCD in patients with diabetes increased ANGPTL4 concentrations, concomitantly with increased NEFA concentrations. ; p. 255-260.
languageeng
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
linktorsrc$$Uhttp://dx.doi.org/10.3945/ajcn.112.043687$$EView_full_text_(authentication_may_be_required)
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Jonker , Jacqueline T
1Smit , Johannes Wa
2Hammer , Sebastiaan
3Snel , Marieke
4Van Der Meer , Rutger W
5Lamb , Hildo J
6Mattijssen , Frits
7Mudde , Karin
8Jazet , Ingrid M
9Dekkers , Olaf M
10De Roos , Albert
11Romijn , Johannes A
12Kersten , Sander
13Rensen , Patrick Cn
titleDietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
descriptionBackground: Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids (NEFAs) raise plasma ANGPTL4 concentrations in humans.Objective: The objective was to assess plasma ANGPTL4 concentrations after various nutritional interventions that increase NEFA concentrations in healthy subjects and in patients with type 2 diabetes mellitus.Design: We studied 4 groups, both at baseline and after 3 d of either fasting (n = 22 healthy men), a very-low-calorie diet (VLCD; n = 10 healthy men and n = 10 patients with diabetes), or a high-fat, high-energy diet (HFED; n = 15 healthy men). Plasma ANGPTL4, NEFA, and triglyceride concentrations were measured.Results: In healthy men, a VLCD increased ANGPTL4 from 13.2 (IQR: 8.1–24.2) at baseline to 18.2 (16.7–33.4) ng/mL (P < 0.05), fasting increased ANGPTL4 from 10.6 (7.6–17.6) to 28.0 (23.1–35.0) ng/mL (P < 0.05), and an HFED increased ANGPTL4 from 13.9 (8.2–22.0) to 17.2 (11.2–23.6) ng/mL (P < 0.05). In men with diabetes, a VLCD also increased ANGPTL4, from 10.9 ± 2.4 to 19.2 ± 3.2 ng/mL (P < 0.05). All interventions significantly increased plasma NEFAs in both healthy men and patients with diabetes. The change in ANGPTL4 positively correlated with the change in NEFA concentrations (β = 0.048, P < 0.001) and negatively correlated with the change in plasma triglycerides (β = −0.051, P = 0.01).Conclusions: Three days of either fasting, a VLCD, or an HFED increased plasma ANGPTL4 concentrations in healthy men, concomitantly with increased plasma NEFA concentrations. Similarly, a VLCD in patients with diabetes increased ANGPTL4 concentrations, concomitantly with increased NEFA concentrations. ; p. 255-260.
subject
0Lipoprotein Lipase
1Free Fatty Acids
2Very Low Calorie Diet
3Patients
4Noninsulin-Dependent Diabetes Mellitus
5Clinical Nutrition
6Volunteers
7Fasting
8Correlation
9Men
10High Energy Diet
11Triacylglycerols
general
0English
1AGRIS (United Nations, Food and Agriculture Organization)
sourceidfaoagris
recordidfaoagrisUS201500150598
rsrctypearticle
creationdate2013
addtitleAmerican journal of clinical nutrition
searchscope
0faoagris
1faoagris_lr
scope
0faoagris
1faoagris_lr
alttitleDietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
issn
000029165
10002-9165
lsr30VSR-Enriched:[pqid, doi, galeid, eissn]
sort
titleDietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
authorJonker , Jacqueline T ; Smit , Johannes Wa ; Hammer , Sebastiaan ; Snel , Marieke ; Van Der Meer , Rutger W ; Lamb , Hildo J ; Mattijssen , Frits ; Mudde , Karin ; Jazet , Ingrid M ; Dekkers , Olaf M ; De Roos , Albert ; Romijn , Johannes A ; Kersten , Sander ; Rensen , Patrick Cn
creationdate20130000
facets
frbrgroupid6389127993770896864
frbrtype5
languageeng
creationdate2013
topic
0Lipoprotein Lipase
1Free Fatty Acids
2Very Low Calorie Diet
3Patients
4Noninsulin-Dependent Diabetes Mellitus
5Clinical Nutrition
6Volunteers
7Fasting
8Correlation
9Men
10High Energy Diet
11Triacylglycerols
collectionAGRIS (United Nations, Food and Agriculture Organization)
prefilterarticles
rsrctypearticles
creatorcontrib
0Jonker , Jacqueline T
1Smit , Johannes Wa
2Hammer , Sebastiaan
3Snel , Marieke
4Van Der Meer , Rutger W
5Lamb , Hildo J
6Mattijssen , Frits
7Mudde , Karin
8Jazet , Ingrid M
9Dekkers , Olaf M
10De Roos , Albert
11Romijn , Johannes A
12Kersten , Sander
13Rensen , Patrick Cn
jtitleAmerican journal of clinical nutrition
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Jonker, Jacqueline T
1Smit, Johannes WA
2Hammer, Sebastiaan
3Snel, Marieke
4van der Meer, Rutger W
5Lamb, Hildo J
6Mattijssen, Frits
7Mudde, Karin
8Jazet, Ingrid M
9Dekkers, Olaf M
10de Roos, Albert
11Romijn, Johannes A
12Kersten, Sander
13Rensen, Patrick CN
atitleDietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
jtitleAmerican journal of clinical nutrition
addtitleDietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
date2013
risdate2013
volume97
issue2
spage255
epage260
pages255-260
issn0002-9165
formatjournal
genrearticle
ristypeJOUR
abstractBackground: Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids (NEFAs) raise plasma ANGPTL4 concentrations in humans.Objective: The objective was to assess plasma ANGPTL4 concentrations after various nutritional interventions that increase NEFA concentrations in healthy subjects and in patients with type 2 diabetes mellitus.Design: We studied 4 groups, both at baseline and after 3 d of either fasting (n = 22 healthy men), a very-low-calorie diet (VLCD; n = 10 healthy men and n = 10 patients with diabetes), or a high-fat, high-energy diet (HFED; n = 15 healthy men). Plasma ANGPTL4, NEFA, and triglyceride concentrations were measured.Results: In healthy men, a VLCD increased ANGPTL4 from 13.2 (IQR: 8.1–24.2) at baseline to 18.2 (16.7–33.4) ng/mL (P < 0.05), fasting increased ANGPTL4 from 10.6 (7.6–17.6) to 28.0 (23.1–35.0) ng/mL (P < 0.05), and an HFED increased ANGPTL4 from 13.9 (8.2–22.0) to 17.2 (11.2–23.6) ng/mL (P < 0.05). In men with diabetes, a VLCD also increased ANGPTL4, from 10.9 ± 2.4 to 19.2 ± 3.2 ng/mL (P < 0.05). All interventions significantly increased plasma NEFAs in both healthy men and patients with diabetes. The change in ANGPTL4 positively correlated with the change in NEFA concentrations (β = 0.048, P < 0.001) and negatively correlated with the change in plasma triglycerides (β = −0.051, P = 0.01).Conclusions: Three days of either fasting, a VLCD, or an HFED increased plasma ANGPTL4 concentrations in healthy men, concomitantly with increased plasma NEFA concentrations. Similarly, a VLCD in patients with diabetes increased ANGPTL4 concentrations, concomitantly with increased NEFA concentrations.
pubAmerican Society for Clinical Nutrition
doi10.3945/ajcn.112.043687
eissn19383207