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Changes in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women.(Paper)(Clinical report)

OBJECTIVE:: Insulin resistance decreases blood flow and volume in fat tissue. We hypothesised that fat tissue nutritive blood flow and volume, and thereby water content, would increase during weight loss and weight maintenance in obese persons. DESIGN:: Longitudinal clinical intervention with a 9-we... Full description

Journal Title: International Journal of Obesity June, 2003, Vol.27(6), p.677
Main Author: Laaksonen, D E
Other Authors: Nuutinen, J , Lahtinen, T , Rissanen, A , Niskanen, L K
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0307-0565
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title: Changes in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women.(Paper)(Clinical report)
format: Article
creator:
  • Laaksonen, D E
  • Nuutinen, J
  • Lahtinen, T
  • Rissanen, A
  • Niskanen, L K
subjects:
  • Insulin Resistance -- Risk Factors
  • Insulin Resistance -- Research
  • Low Calorie Diet -- Health Aspects
  • Overweight Persons -- Health Aspects
  • Overweight Persons -- Food And Nutrition
  • Overweight Persons -- Comparative Analysis
  • Weight Loss -- Health Aspects
  • Weight Loss -- Research
ispartof: International Journal of Obesity, June, 2003, Vol.27(6), p.677
description: OBJECTIVE:: Insulin resistance decreases blood flow and volume in fat tissue. We hypothesised that fat tissue nutritive blood flow and volume, and thereby water content, would increase during weight loss and weight maintenance in obese persons. DESIGN:: Longitudinal clinical intervention with a 9-week very-low-calorie diet (VLCD) followed by one year of weight maintenance. SUBJECTS:: Obese men (n=13) and women (n=14) with the metabolic syndrome. MEASUREMENTS:: Water content of abdominal subcutaneous fat tissue as estimated by a sensor on the skin surface measuring the dielectric constant at 300 MHz. Anthropometric measures of fatness and fat distribution. Biochemical measures related to insulin resistance. RESULTS:: Subjects lost 14.5[plus or minus]3.4% of body weight during the VLCD, and generally sustained this weight loss during weight maintenance. Insulin sensitivity as estimated by an index (qualitative insulin sensitivity check index) increased during the VLCD, and remained increased throughout weight maintenance. The dielectric constant increased from 23.3[plus or minus]2.3 to 25.0[plus or minus]2.1 (P [less than] 0.001) during the VLCD, and further to 27.8[plus or minus]1.9 (P [less than] 0.001) during weight maintenance, indicating an increase in the water content of subcutaneous fat. The increase in subcutaneous fat water content did not correlate with weight loss and other measures of adiposity during the VLCD, but there was an inverse correlation that strengthened in significance from baseline to 6, 9 and 12 mo (r=-0.32 to -0.64, P=0.079-0.002). Increases in subcutaneous fat water content also correlated with improvements in insulin sensitivity at 6, 9 and 12 months of weight maintenance (r=0.34-0.54, P=0.094-0.006). CONCLUSIONS:: Water content of abdominal subcutaneous adipose tissue increases with weight loss in obese persons with the metabolic syndrome, and may reflect increased subcutaneous fat tissue nutritive blood flow. The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration. International Journal of Obesity (2003) 27, 677-683. doi: 10.1038/sj.ijo.0802296 Keywords: Insulin resistance, Metabolic syndrome, Subcutaneous fat tissue, Very-low-calorie diet, Weight maintenance
language: English
source:
identifier: ISSN: 0307-0565
fulltext: fulltext
issn:
  • 0307-0565
  • 03070565
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titleChanges in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women.(Paper)(Clinical report)
creatorLaaksonen, D E ; Nuutinen, J ; Lahtinen, T ; Rissanen, A ; Niskanen, L K
ispartofInternational Journal of Obesity, June, 2003, Vol.27(6), p.677
identifierISSN: 0307-0565
subjectInsulin Resistance -- Risk Factors ; Insulin Resistance -- Research ; Low Calorie Diet -- Health Aspects ; Overweight Persons -- Health Aspects ; Overweight Persons -- Food And Nutrition ; Overweight Persons -- Comparative Analysis ; Weight Loss -- Health Aspects ; Weight Loss -- Research
descriptionOBJECTIVE:: Insulin resistance decreases blood flow and volume in fat tissue. We hypothesised that fat tissue nutritive blood flow and volume, and thereby water content, would increase during weight loss and weight maintenance in obese persons. DESIGN:: Longitudinal clinical intervention with a 9-week very-low-calorie diet (VLCD) followed by one year of weight maintenance. SUBJECTS:: Obese men (n=13) and women (n=14) with the metabolic syndrome. MEASUREMENTS:: Water content of abdominal subcutaneous fat tissue as estimated by a sensor on the skin surface measuring the dielectric constant at 300 MHz. Anthropometric measures of fatness and fat distribution. Biochemical measures related to insulin resistance. RESULTS:: Subjects lost 14.5[plus or minus]3.4% of body weight during the VLCD, and generally sustained this weight loss during weight maintenance. Insulin sensitivity as estimated by an index (qualitative insulin sensitivity check index) increased during the VLCD, and remained increased throughout weight maintenance. The dielectric constant increased from 23.3[plus or minus]2.3 to 25.0[plus or minus]2.1 (P [less than] 0.001) during the VLCD, and further to 27.8[plus or minus]1.9 (P [less than] 0.001) during weight maintenance, indicating an increase in the water content of subcutaneous fat. The increase in subcutaneous fat water content did not correlate with weight loss and other measures of adiposity during the VLCD, but there was an inverse correlation that strengthened in significance from baseline to 6, 9 and 12 mo (r=-0.32 to -0.64, P=0.079-0.002). Increases in subcutaneous fat water content also correlated with improvements in insulin sensitivity at 6, 9 and 12 months of weight maintenance (r=0.34-0.54, P=0.094-0.006). CONCLUSIONS:: Water content of abdominal subcutaneous adipose tissue increases with weight loss in obese persons with the metabolic syndrome, and may reflect increased subcutaneous fat tissue nutritive blood flow. The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration. International Journal of Obesity (2003) 27, 677-683. doi: 10.1038/sj.ijo.0802296 Keywords: Insulin resistance, Metabolic syndrome, Subcutaneous fat tissue, Very-low-calorie diet, Weight maintenance
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titleChanges in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women.(Paper)(Clinical report)
descriptionOBJECTIVE:: Insulin resistance decreases blood flow and volume in fat tissue. We hypothesised that fat tissue nutritive blood flow and volume, and thereby water content, would increase during weight loss and weight maintenance in obese persons. DESIGN:: Longitudinal clinical intervention with a 9-week very-low-calorie diet (VLCD) followed by one year of weight maintenance. SUBJECTS:: Obese men (n=13) and women (n=14) with the metabolic syndrome. MEASUREMENTS:: Water content of abdominal subcutaneous fat tissue as estimated by a sensor on the skin surface measuring the dielectric constant at 300 MHz. Anthropometric measures of fatness and fat distribution. Biochemical measures related to insulin resistance. RESULTS:: Subjects lost 14.5[plus or minus]3.4% of body weight during the VLCD, and generally sustained this weight loss during weight maintenance. Insulin sensitivity as estimated by an index (qualitative insulin sensitivity check index) increased during the VLCD, and remained increased throughout weight maintenance. The dielectric constant increased from 23.3[plus or minus]2.3 to 25.0[plus or minus]2.1 (P [less than] 0.001) during the VLCD, and further to 27.8[plus or minus]1.9 (P [less than] 0.001) during weight maintenance, indicating an increase in the water content of subcutaneous fat. The increase in subcutaneous fat water content did not correlate with weight loss and other measures of adiposity during the VLCD, but there was an inverse correlation that strengthened in significance from baseline to 6, 9 and 12 mo (r=-0.32 to -0.64, P=0.079-0.002). Increases in subcutaneous fat water content also correlated with improvements in insulin sensitivity at 6, 9 and 12 months of weight maintenance (r=0.34-0.54, P=0.094-0.006). CONCLUSIONS:: Water content of abdominal subcutaneous adipose tissue increases with weight loss in obese persons with the metabolic syndrome, and may reflect increased subcutaneous fat tissue nutritive blood flow. The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration. International Journal of Obesity (2003) 27, 677-683. doi: 10.1038/sj.ijo.0802296 Keywords: Insulin resistance, Metabolic syndrome, Subcutaneous fat tissue, Very-low-calorie diet, Weight maintenance
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titleChanges in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women.(Paper)(Clinical report)
authorLaaksonen, D E ; Nuutinen, J ; Lahtinen, T ; Rissanen, A ; Niskanen, L K
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abstractOBJECTIVE:: Insulin resistance decreases blood flow and volume in fat tissue. We hypothesised that fat tissue nutritive blood flow and volume, and thereby water content, would increase during weight loss and weight maintenance in obese persons. DESIGN:: Longitudinal clinical intervention with a 9-week very-low-calorie diet (VLCD) followed by one year of weight maintenance. SUBJECTS:: Obese men (n=13) and women (n=14) with the metabolic syndrome. MEASUREMENTS:: Water content of abdominal subcutaneous fat tissue as estimated by a sensor on the skin surface measuring the dielectric constant at 300 MHz. Anthropometric measures of fatness and fat distribution. Biochemical measures related to insulin resistance. RESULTS:: Subjects lost 14.5[plus or minus]3.4% of body weight during the VLCD, and generally sustained this weight loss during weight maintenance. Insulin sensitivity as estimated by an index (qualitative insulin sensitivity check index) increased during the VLCD, and remained increased throughout weight maintenance. The dielectric constant increased from 23.3[plus or minus]2.3 to 25.0[plus or minus]2.1 (P [less than] 0.001) during the VLCD, and further to 27.8[plus or minus]1.9 (P [less than] 0.001) during weight maintenance, indicating an increase in the water content of subcutaneous fat. The increase in subcutaneous fat water content did not correlate with weight loss and other measures of adiposity during the VLCD, but there was an inverse correlation that strengthened in significance from baseline to 6, 9 and 12 mo (r=-0.32 to -0.64, P=0.079-0.002). Increases in subcutaneous fat water content also correlated with improvements in insulin sensitivity at 6, 9 and 12 months of weight maintenance (r=0.34-0.54, P=0.094-0.006). CONCLUSIONS:: Water content of abdominal subcutaneous adipose tissue increases with weight loss in obese persons with the metabolic syndrome, and may reflect increased subcutaneous fat tissue nutritive blood flow. The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration. International Journal of Obesity (2003) 27, 677-683. doi: 10.1038/sj.ijo.0802296 Keywords: Insulin resistance, Metabolic syndrome, Subcutaneous fat tissue, Very-low-calorie diet, Weight maintenance
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