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Twenty-four-hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults

Background: This is a continuation of investigations of the relations between amino acid kinetics and amino acid dietary requirements in healthy adults. Objective: The aim was to investigate the 24-h pattern and rate of the metabolism of an L-[1-[sup.13]C]-2-aminoadipic acid ([[sup.13]C]AAA) tracer... Full description

Journal Title: American Journal of Clinical Nutrition Oct, 1998, Vol.68(4), p.827(13)
Main Author: Khoury, Antoine E. El -
Other Authors: Basile, Anibal , Beaumier, Louis , Wang, San Y. , Amiri, Hanan A. Al - , Selvaraj, Ambalini , Wong, Sue , Atkinson, Alan , Ajami, Alfred M. , Young, Vernon R.
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ID: ISSN: 0002-9165
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title: Twenty-four-hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults
format: Article
creator:
  • Khoury, Antoine E. El -
  • Basile, Anibal
  • Beaumier, Louis
  • Wang, San Y.
  • Amiri, Hanan A. Al -
  • Selvaraj, Ambalini
  • Wong, Sue
  • Atkinson, Alan
  • Ajami, Alfred M.
  • Young, Vernon R.
subjects:
  • Amino Acid Metabolism -- Measurement
  • Lysine -- Physiological Aspects
  • Radioactive Tracers -- Usage
ispartof: American Journal of Clinical Nutrition, Oct, 1998, Vol.68(4), p.827(13)
description: Background: This is a continuation of investigations of the relations between amino acid kinetics and amino acid dietary requirements in healthy adults. Objective: The aim was to investigate the 24-h pattern and rate of the metabolism of an L-[1-[sup.13]C]-2-aminoadipic acid ([[sup.13]C]AAA) tracer and of whole-body L-[1-[sup.13]C]lysine ([[sup.13]C]lysine) oxidation and balance in healthy, young adults receiving a generous intake of lysine. Design: Thirteen healthy adults were given an adequate, L-amino acid-based diet supplying 77 mg lysine, [kg.sup.1].[d.sup.1] for 6 d before the tracer studies. Two subjects received [[sup.13]C]AAA intravenously and 2 received it orally; 3 subjects received [[sup.13]C]lysine intravenously and 6 received it orally. We measured [sup.13]C[O.sub.2] output, plasma [[sup.13]C]AAA and [[sup.13]C]lysine enrichment, and urinary [[sup.13]C]AAA. Results: [[sup.13]C]AAA oxidation was estimated to be higher after the orally administered than after the intravenously administer tracer; plasma [[sup.13]C]AAA was similar to urinary [[sup.13]C]AAA. Whole-body lysine oxidation showed a rhythm that was induced by meal feeding. The intravenous [[sup.13]C]lysine tracer gave mean estimates of lysine balances (lysine intake minus oxidation) that apparently were too low (-15.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1]) or too high (16.6 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], P [is less than] 0.05 from zero balance) on the basis of urinary [[sup.13]C]AAA or plasma [[sup.13]C]lysine estimates of oxidation, respectively. For the orally administered tracer and plasma [[sup.13]C]lysine enrichment, the mean balance was slightly positive (8.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], p [is less than] 0.05 from zero). Conclusions: Use of urinary [[sup.13]C]AAA as an index of the enrichment of the precursor pool did not appear to significantly improve the estimate of the fasting and feeding components of daily lysine balance. For estimates of daily, whole-body lysine oxidation, we propose use of plasma [[sup.13]C]lysine with a 24-h, orally administered tracer protocol. Am J Clin Nutr 1998;68:827-39.
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identifier: ISSN: 0002-9165
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  • 0002-9165
  • 00029165
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titleTwenty-four-hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults
creatorKhoury, Antoine E. El - ; Basile, Anibal ; Beaumier, Louis ; Wang, San Y. ; Amiri, Hanan A. Al - ; Selvaraj, Ambalini ; Wong, Sue ; Atkinson, Alan ; Ajami, Alfred M. ; Young, Vernon R.
ispartofAmerican Journal of Clinical Nutrition, Oct, 1998, Vol.68(4), p.827(13)
identifierISSN: 0002-9165
subjectAmino Acid Metabolism -- Measurement ; Lysine -- Physiological Aspects ; Radioactive Tracers -- Usage
descriptionBackground: This is a continuation of investigations of the relations between amino acid kinetics and amino acid dietary requirements in healthy adults. Objective: The aim was to investigate the 24-h pattern and rate of the metabolism of an L-[1-[sup.13]C]-2-aminoadipic acid ([[sup.13]C]AAA) tracer and of whole-body L-[1-[sup.13]C]lysine ([[sup.13]C]lysine) oxidation and balance in healthy, young adults receiving a generous intake of lysine. Design: Thirteen healthy adults were given an adequate, L-amino acid-based diet supplying 77 mg lysine, [kg.sup.1].[d.sup.1] for 6 d before the tracer studies. Two subjects received [[sup.13]C]AAA intravenously and 2 received it orally; 3 subjects received [[sup.13]C]lysine intravenously and 6 received it orally. We measured [sup.13]C[O.sub.2] output, plasma [[sup.13]C]AAA and [[sup.13]C]lysine enrichment, and urinary [[sup.13]C]AAA. Results: [[sup.13]C]AAA oxidation was estimated to be higher after the orally administered than after the intravenously administer tracer; plasma [[sup.13]C]AAA was similar to urinary [[sup.13]C]AAA. Whole-body lysine oxidation showed a rhythm that was induced by meal feeding. The intravenous [[sup.13]C]lysine tracer gave mean estimates of lysine balances (lysine intake minus oxidation) that apparently were too low (-15.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1]) or too high (16.6 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], P [is less than] 0.05 from zero balance) on the basis of urinary [[sup.13]C]AAA or plasma [[sup.13]C]lysine estimates of oxidation, respectively. For the orally administered tracer and plasma [[sup.13]C]lysine enrichment, the mean balance was slightly positive (8.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], p [is less than] 0.05 from zero). Conclusions: Use of urinary [[sup.13]C]AAA as an index of the enrichment of the precursor pool did not appear to significantly improve the estimate of the fasting and feeding components of daily lysine balance. For estimates of daily, whole-body lysine oxidation, we propose use of plasma [[sup.13]C]lysine with a 24-h, orally administered tracer protocol. Am J Clin Nutr 1998;68:827-39.
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6Wong, Sue
7Atkinson, Alan
8Ajami, Alfred M
9Young, Vernon R
titleTwenty-four-hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults.
descriptionBackground: This is a continuation of investigations of the relations between amino acid kinetics and amino acid dietary requirements in healthy adults. Objective: The aim was to investigate the 24-h pattern and rate of the metabolism of an L-[1-[sup.13]C]-2-aminoadipic acid ([[sup.13]C]AAA) tracer and of whole-body L-[1-[sup.13]C]lysine ([[sup.13]C]lysine) oxidation and balance in healthy, young adults receiving a generous intake of lysine. Design: Thirteen healthy adults were given an adequate, L-amino acid-based diet supplying 77 mg lysine, [kg.sup.1].[d.sup.1] for 6 d before the tracer studies. Two subjects received [[sup.13]C]AAA intravenously and 2 received it orally; 3 subjects received [[sup.13]C]lysine intravenously and 6 received it orally. We measured [sup.13]C[O.sub.2] output, plasma [[sup.13]C]AAA and [[sup.13]C]lysine enrichment, and urinary [[sup.13]C]AAA. Results: [[sup.13]C]AAA oxidation was estimated to be higher after the orally administered than after the intravenously administer tracer; plasma [[sup.13]C]AAA was similar to urinary [[sup.13]C]AAA. Whole-body lysine oxidation showed a rhythm that was induced by meal feeding. The intravenous [[sup.13]C]lysine tracer gave mean estimates of lysine balances (lysine intake minus oxidation) that apparently were too low (-15.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1]) or too high (16.6 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], P [is less than] 0.05 from zero balance) on the basis of urinary [[sup.13]C]AAA or plasma [[sup.13]C]lysine estimates of oxidation, respectively. For the orally administered tracer and plasma [[sup.13]C]lysine enrichment, the mean balance was slightly positive (8.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], p [is less than] 0.05 from zero). Conclusions: Use of urinary [[sup.13]C]AAA as an index of the enrichment of the precursor pool did not appear to significantly improve the estimate of the fasting and feeding components of daily lysine balance. For estimates of daily, whole-body lysine oxidation, we propose use of plasma [[sup.13]C]lysine with a 24-h, orally administered tracer protocol. Am J Clin Nutr 1998;68:827-39.
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titleTwenty-four-hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults.
authorKhoury, Antoine E. El - ; Basile, Anibal ; Beaumier, Louis ; Wang, San Y. ; Amiri, Hanan A. Al - ; Selvaraj, Ambalini ; Wong, Sue ; Atkinson, Alan ; Ajami, Alfred M. ; Young, Vernon R.
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abstractBackground: This is a continuation of investigations of the relations between amino acid kinetics and amino acid dietary requirements in healthy adults. Objective: The aim was to investigate the 24-h pattern and rate of the metabolism of an L-[1-[sup.13]C]-2-aminoadipic acid ([[sup.13]C]AAA) tracer and of whole-body L-[1-[sup.13]C]lysine ([[sup.13]C]lysine) oxidation and balance in healthy, young adults receiving a generous intake of lysine. Design: Thirteen healthy adults were given an adequate, L-amino acid-based diet supplying 77 mg lysine, [kg.sup.1].[d.sup.1] for 6 d before the tracer studies. Two subjects received [[sup.13]C]AAA intravenously and 2 received it orally; 3 subjects received [[sup.13]C]lysine intravenously and 6 received it orally. We measured [sup.13]C[O.sub.2] output, plasma [[sup.13]C]AAA and [[sup.13]C]lysine enrichment, and urinary [[sup.13]C]AAA. Results: [[sup.13]C]AAA oxidation was estimated to be higher after the orally administered than after the intravenously administer tracer; plasma [[sup.13]C]AAA was similar to urinary [[sup.13]C]AAA. Whole-body lysine oxidation showed a rhythm that was induced by meal feeding. The intravenous [[sup.13]C]lysine tracer gave mean estimates of lysine balances (lysine intake minus oxidation) that apparently were too low (-15.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1]) or too high (16.6 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], P [is less than] 0.05 from zero balance) on the basis of urinary [[sup.13]C]AAA or plasma [[sup.13]C]lysine estimates of oxidation, respectively. For the orally administered tracer and plasma [[sup.13]C]lysine enrichment, the mean balance was slightly positive (8.7 mg [multiplied by] [kg.sup.1] [multiplied by] [d.sup.1], p [is less than] 0.05 from zero). Conclusions: Use of urinary [[sup.13]C]AAA as an index of the enrichment of the precursor pool did not appear to significantly improve the estimate of the fasting and feeding components of daily lysine balance. For estimates of daily, whole-body lysine oxidation, we propose use of plasma [[sup.13]C]lysine with a 24-h, orally administered tracer protocol. Am J Clin Nutr 1998;68:827-39.
pubAmerican Society for Clinical Nutrition, Inc.
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doi10.1093/ajcn/68.4.827
pages827-839
eissn19383207
date1998-10-01