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Is it time for in silico simulation of drug cardiac side effects?(Report)

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1749-6632.2011.06324.x Byline: Gary R. Mirams (1), Denis Noble (2) Keywords: torsade de pointes; cardiac toxicity; computer modeling; hERG Abstract: Cardiac simulation is used to integrate informati... Full description

Journal Title: Annals of the New York Academy of Sciences Dec, 2011, Vol.1245, p.44(4)
Main Author: Mirams, Gary R.
Other Authors: Noble, Denis
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 0077-8923
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recordid: gale_hrca275983352
title: Is it time for in silico simulation of drug cardiac side effects?(Report)
format: Article
creator:
  • Mirams, Gary R.
  • Noble, Denis
subjects:
  • Computer Simulation -- Analysis
  • Computer Simulation -- Models
ispartof: Annals of the New York Academy of Sciences, Dec, 2011, Vol.1245, p.44(4)
description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1749-6632.2011.06324.x Byline: Gary R. Mirams (1), Denis Noble (2) Keywords: torsade de pointes; cardiac toxicity; computer modeling; hERG Abstract: Cardiac simulation is used to integrate information on drug action to predict side effects on the whole heart. Could simulation begin to replace animal models? Author Affiliation: (1)Department of Computer Science, University of Oxford, Oxford, United Kingdom (2)Department of Physiology, Anatomy & Genetics, University of Oxford, United Kingdom Article note: Gary Mirams, Department of Computer Science, University of Oxford, Parks Road, Oxford, OX1 3QD, UK. gary.mirams@cs.ox.ac.uk
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 0077-8923
fulltext: fulltext
issn:
  • 0077-8923
  • 00778923
url: Link


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descriptionTo authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1749-6632.2011.06324.x Byline: Gary R. Mirams (1), Denis Noble (2) Keywords: torsade de pointes; cardiac toxicity; computer modeling; hERG Abstract: Cardiac simulation is used to integrate information on drug action to predict side effects on the whole heart. Could simulation begin to replace animal models? Author Affiliation: (1)Department of Computer Science, University of Oxford, Oxford, United Kingdom (2)Department of Physiology, Anatomy & Genetics, University of Oxford, United Kingdom Article note: Gary Mirams, Department of Computer Science, University of Oxford, Parks Road, Oxford, OX1 3QD, UK. gary.mirams@cs.ox.ac.uk
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abstractTo authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1749-6632.2011.06324.x Byline: Gary R. Mirams (1), Denis Noble (2) Keywords: torsade de pointes; cardiac toxicity; computer modeling; hERG Abstract: Cardiac simulation is used to integrate information on drug action to predict side effects on the whole heart. Could simulation begin to replace animal models? Author Affiliation: (1)Department of Computer Science, University of Oxford, Oxford, United Kingdom (2)Department of Physiology, Anatomy & Genetics, University of Oxford, United Kingdom Article note: Gary Mirams, Department of Computer Science, University of Oxford, Parks Road, Oxford, OX1 3QD, UK. gary.mirams@cs.ox.ac.uk
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