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Life-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).(Report)(Author abstract)

We measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas C... Full description

Journal Title: The Journals of Gerontology Series A, April, 2013, Vol.68(4), p.349(10)
Main Author: Gribble, Kristin E.
Other Authors: Welch, David B. Mark
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1079-5006
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recordid: gale_hrca324757398
title: Life-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).(Report)(Author abstract)
format: Article
creator:
  • Gribble, Kristin E.
  • Welch, David B. Mark
subjects:
  • Life Span (Biology) -- Research
  • Longevity -- Research
  • Low Calorie Diet -- Usage
  • Low Calorie Diet -- Methods
  • Rotifers -- Physiological Aspects
ispartof: The Journals of Gerontology, Series A, April, 2013, Vol.68(4), p.349(10)
description: We measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension. Key Words: Caloric restriction--Life span extension--Aging--Resource allocation--Rotifer doi: 10.1093/gerona/gls170
language: English
source:
identifier: ISSN: 1079-5006
fulltext: fulltext
issn:
  • 1079-5006
  • 10795006
url: Link


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titleLife-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).(Report)(Author abstract)
creatorGribble, Kristin E. ; Welch, David B. Mark
ispartofThe Journals of Gerontology, Series A, April, 2013, Vol.68(4), p.349(10)
identifierISSN: 1079-5006
subjectLife Span (Biology) -- Research ; Longevity -- Research ; Low Calorie Diet -- Usage ; Low Calorie Diet -- Methods ; Rotifers -- Physiological Aspects
descriptionWe measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension. Key Words: Caloric restriction--Life span extension--Aging--Resource allocation--Rotifer doi: 10.1093/gerona/gls170
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titleLife-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).(Report)(Author abstract)
descriptionWe measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension. Key Words: Caloric restriction--Life span extension--Aging--Resource allocation--Rotifer doi: 10.1093/gerona/gls170
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abstractWe measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension. Key Words: Caloric restriction--Life span extension--Aging--Resource allocation--Rotifer doi: 10.1093/gerona/gls170
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