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Surface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3-dimensional reconstruction.(Report)

Objective Loss of surface maturation and cytonuclear atypia have been regarded as the pathological 'gold standard' for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect... Full description

Journal Title: Gut Nov, 2013, Vol.62(11), p.1547(9)
Main Author: Ming Li
Other Authors: Xiu - Li Zuo , Tao Yu , Xiao - Meng Gu , Cheng - Jun Zhou , Zhen Li , Hong Liu , Rui Ji , Yan - Yan Dong , Chang - Qing Li , Yan - Qing Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0017-5749
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recordid: gale_hrca359373383
title: Surface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3-dimensional reconstruction.(Report)
format: Article
creator:
  • Ming Li
  • Xiu - Li Zuo
  • Tao Yu
  • Xiao - Meng Gu
  • Cheng - Jun Zhou
  • Zhen Li
  • Hong Liu
  • Rui Ji
  • Yan - Yan Dong
  • Chang - Qing Li
  • Yan - Qing Li
subjects:
  • Endoscopy -- Usage
  • Squamous Cell Carcinoma -- Diagnosis
  • Diagnostic Imaging -- Usage
ispartof: Gut, Nov, 2013, Vol.62(11), p.1547(9)
description: Objective Loss of surface maturation and cytonuclear atypia have been regarded as the pathological 'gold standard' for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect surface maturation and screen for oesophageal squamous cell intraepithelial neoplasia. The aim of this study was to apply a 3-dimensional (3D) confocal endomicroscopic imaging technique to investigate the surface maturation of the oesophageal epithelium and develop new 2-dimensional confocal endomicroscopic criteria based on surface maturation. Design In the 3D reconstruction phase, intrapapillary capillary loops were reconstructed to demonstrate the stereo configuration of the oesophageal epithelium, and a novel surface maturation scoring (SMS) method for plane confocal images was developed based on the interpretation of the 3D microstructure. In the SMS diagnostic phase, 1214 patients were screened and confocal images from 64 non-invasive oesophageal lesions were independently evaluated using SMS and previous methods. Results We successfully obtained and interpreted 3D confocal images of the human oesophageal epithelium for the first time. The sensitivity (81.0%, 95% CI 58.1% to 94.6%) and specificity (90.7%, 95% CI 77.9% to 97.4%) of the newly established SMS were superior to previous confocal approaches in distinguishing squamous intraepithelial neoplasia from other non-invasive lesions. Conclusions 3D confocal endomicroscopic imaging provides valuable insight into the stereo configuration of the human oesophageal epithelium. SMS is a novel and promising diagnostic method to distinguish neoplasia during ongoing endoscopy.
language: English
source:
identifier: ISSN: 0017-5749
fulltext: no_fulltext
issn:
  • 0017-5749
  • 00175749
url: Link


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titleSurface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3-dimensional reconstruction.(Report)
creatorMing Li ; Xiu - Li Zuo ; Tao Yu ; Xiao - Meng Gu ; Cheng - Jun Zhou ; Zhen Li ; Hong Liu ; Rui Ji ; Yan - Yan Dong ; Chang - Qing Li ; Yan - Qing Li
ispartofGut, Nov, 2013, Vol.62(11), p.1547(9)
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subjectEndoscopy -- Usage ; Squamous Cell Carcinoma -- Diagnosis ; Diagnostic Imaging -- Usage
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descriptionObjective Loss of surface maturation and cytonuclear atypia have been regarded as the pathological 'gold standard' for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect surface maturation and screen for oesophageal squamous cell intraepithelial neoplasia. The aim of this study was to apply a 3-dimensional (3D) confocal endomicroscopic imaging technique to investigate the surface maturation of the oesophageal epithelium and develop new 2-dimensional confocal endomicroscopic criteria based on surface maturation. Design In the 3D reconstruction phase, intrapapillary capillary loops were reconstructed to demonstrate the stereo configuration of the oesophageal epithelium, and a novel surface maturation scoring (SMS) method for plane confocal images was developed based on the interpretation of the 3D microstructure. In the SMS diagnostic phase, 1214 patients were screened and confocal images from 64 non-invasive oesophageal lesions were independently evaluated using SMS and previous methods. Results We successfully obtained and interpreted 3D confocal images of the human oesophageal epithelium for the first time. The sensitivity (81.0%, 95% CI 58.1% to 94.6%) and specificity (90.7%, 95% CI 77.9% to 97.4%) of the newly established SMS were superior to previous confocal approaches in distinguishing squamous intraepithelial neoplasia from other non-invasive lesions. Conclusions 3D confocal endomicroscopic imaging provides valuable insight into the stereo configuration of the human oesophageal epithelium. SMS is a novel and promising diagnostic method to distinguish neoplasia during ongoing endoscopy.
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titleSurface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3-dimensional reconstruction.(Report)
authorMing Li ; Xiu - Li Zuo ; Tao Yu ; Xiao - Meng Gu ; Cheng - Jun Zhou ; Zhen Li ; Hong Liu ; Rui Ji ; Yan - Yan Dong ; Chang - Qing Li ; Yan - Qing Li
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