schliessen

Filtern

 

Bibliotheken

Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study.(ORIGINAL ARTICLE)(Report)

BACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs;< 800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). D... Full description

Journal Title: International Journal of Obesity Feb, 2014, Vol.38(2), p.279(6)
Main Author: Johansson, K.
Other Authors: Sundstrom, J. , Marcus, C. , Hemmingsson, E. , Neovius, M.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0307-0565 ; DOI: 10.1038/ijo.2013.83
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: gale_hrca361846392
title: Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study.(ORIGINAL ARTICLE)(Report)
format: Article
creator:
  • Johansson, K.
  • Sundstrom, J.
  • Marcus, C.
  • Hemmingsson, E.
  • Neovius, M.
subjects:
  • Gallstones -- Risk Factors
  • Gallstones -- Research
  • Cholecystectomy -- Research
  • Low Calorie Diet -- Research
  • Weight Loss -- Complications And Side Effects
  • Weight Loss -- Research
ispartof: International Journal of Obesity, Feb, 2014, Vol.38(2), p.279(6)
description: BACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs;< 800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). DESIGN: A 1-year matched cohort study of consecutively enrolled adults in a commercial weight loss program conducted at 28 Swedish centers between 2006 and 2009. A 3-month weight loss phase of VLCD (500 kcal per day) or LCD (1200-1500 kcal per day) was followed by a 9-month weight maintenance phase. Matching (1:1) was performed by age, sex, body mass index, waist circumference and gallstone history (n = 3320:3320). Gallstone and cholecystectomy data were retrieved from the Swedish National Patient Register. RESULTS: One-year weight loss was greater in the VLCD than in the LCD group (-11.1 versus -8.1 kg; adjusted difference, - 2.8kg, 95% CI -3.1 to -2.4;P
language: English
source:
identifier: ISSN: 0307-0565 ; DOI: 10.1038/ijo.2013.83
fulltext: fulltext
issn:
  • 0307-0565
  • 03070565
url: Link


@attributes
ID859782167
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid361846392
sourceidgale_hrca
recordidTN_gale_hrca361846392
sourceformatXML
sourcesystemPC
pqid1499145870
galeid361846392
display
typearticle
titleRisk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study.(ORIGINAL ARTICLE)(Report)
creatorJohansson, K. ; Sundstrom, J. ; Marcus, C. ; Hemmingsson, E. ; Neovius, M.
ispartofInternational Journal of Obesity, Feb, 2014, Vol.38(2), p.279(6)
identifierISSN: 0307-0565 ; DOI: 10.1038/ijo.2013.83
subjectGallstones -- Risk Factors ; Gallstones -- Research ; Cholecystectomy -- Research ; Low Calorie Diet -- Research ; Weight Loss -- Complications And Side Effects ; Weight Loss -- Research
descriptionBACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs;< 800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). DESIGN: A 1-year matched cohort study of consecutively enrolled adults in a commercial weight loss program conducted at 28 Swedish centers between 2006 and 2009. A 3-month weight loss phase of VLCD (500 kcal per day) or LCD (1200-1500 kcal per day) was followed by a 9-month weight maintenance phase. Matching (1:1) was performed by age, sex, body mass index, waist circumference and gallstone history (n = 3320:3320). Gallstone and cholecystectomy data were retrieved from the Swedish National Patient Register. RESULTS: One-year weight loss was greater in the VLCD than in the LCD group (-11.1 versus -8.1 kg; adjusted difference, - 2.8kg, 95% CI -3.1 to -2.4;P<0.001). During 6361 person-years, 48 and 14 gallstones requiring hospital care occurred in the VLCD and LCD groups, respectively, (152 versus 44/10000 person-years;hazard ratio, 3.4, 95% CI 1.8-6.3; P<0.001; number-needed-to-harm, 92, 95% CI 63-168;P<0.001). Of the 62 gallstone events, 38 (61%) resulted in cholecystectomy (29 versus 9; hazard ratio, 3.2, 95% CI 1.5-6.8;P = 0.003;number-needed-to-harm, 151, 95% CI 94-377;P<0.001). Adjusting for 3-month weight loss attenuated the hazard ratios, but the risk remained higher with VLCD than LCD for gallstones (2.5, 95% CI 1.3-5.1;P = 0.009) and became borderline for cholecystectomy (2.2, 95% CI 0.9-5.2;P = 0.08). CONCLUSION: The risk of symptomatic gallstones requiring hospitalization or cholecystectomy, albeit low, was 3-fold greater with VLCD than LCD during the 1-year commercial weight loss program. International Journal of Obesity (2014) 38, 279-284; doi:10.1038/ijo.2013.83 Keywords: VLCD; LCD; commercial weight loss; gallstones; cholecystectomy; adverse events
languageEnglish
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Johansson, K
1Johansson
2Sundstrom, J
3Marcus, C
4Hemmingsson, E
5Neovius, M
titleRisk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study.(ORIGINAL ARTICLE)(Report)
descriptionBACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs;< 800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). DESIGN: A 1-year matched cohort study of consecutively enrolled adults in a commercial weight loss program conducted at 28 Swedish centers between 2006 and 2009. A 3-month weight loss phase of VLCD (500 kcal per day) or LCD (1200-1500 kcal per day) was followed by a 9-month weight maintenance phase. Matching (1:1) was performed by age, sex, body mass index, waist circumference and gallstone history (n = 3320:3320). Gallstone and cholecystectomy data were retrieved from the Swedish National Patient Register. RESULTS: One-year weight loss was greater in the VLCD than in the LCD group (-11.1 versus -8.1 kg; adjusted difference, - 2.8kg, 95% CI -3.1 to -2.4;P<0.001). During 6361 person-years, 48 and 14 gallstones requiring hospital care occurred in the VLCD and LCD groups, respectively, (152 versus 44/10000 person-years;hazard ratio, 3.4, 95% CI 1.8-6.3; P<0.001; number-needed-to-harm, 92, 95% CI 63-168;P<0.001). Of the 62 gallstone events, 38 (61%) resulted in cholecystectomy (29 versus 9; hazard ratio, 3.2, 95% CI 1.5-6.8;P = 0.003;number-needed-to-harm, 151, 95% CI 94-377;P<0.001). Adjusting for 3-month weight loss attenuated the hazard ratios, but the risk remained higher with VLCD than LCD for gallstones (2.5, 95% CI 1.3-5.1;P = 0.009) and became borderline for cholecystectomy (2.2, 95% CI 0.9-5.2;P = 0.08). CONCLUSION: The risk of symptomatic gallstones requiring hospitalization or cholecystectomy, albeit low, was 3-fold greater with VLCD than LCD during the 1-year commercial weight loss program. International Journal of Obesity (2014) 38, 279-284; doi:10.1038/ijo.2013.83 Keywords: VLCD; LCD; commercial weight loss; gallstones; cholecystectomy; adverse events
subject
0Gallstones--Risk factors
1Gallstones--Research
2Cholecystectomy--Research
3Low calorie diet--Research
4Weight loss--Complications and side effects
5Weight loss--Research
6Sweden
74EUSW
general
0English
1Nature Publishing Group
2Cengage Learning, Inc.
sourceidgale_hrca
recordidgale_hrca361846392
issn
00307-0565
103070565
rsrctypearticle
creationdate2014
recordtypearticle
addtitleInternational Journal of Obesity
searchscopegale_hrca
scopegale_hrca
lsr30VSR-Enriched:[eissn, galeid, pqid, pages]
sort
titleRisk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study.(ORIGINAL ARTICLE)(Report)
authorJohansson, K. ; Sundstrom, J. ; Marcus, C. ; Hemmingsson, E. ; Neovius, M.
creationdate20140201
facets
frbrgroupid6105230984472989407
frbrtype5
languageeng
creationdate2014
topic
0Gallstones–Risk Factors
1Gallstones–Research
2Cholecystectomy–Research
3Low Calorie Diet–Research
4Weight Loss–Complications And Side Effects
5Weight Loss–Research
collectionHealth Reference Center Academic (Gale)
prefilterarticles
rsrctypearticles
creatorcontrib
0Johansson, K.
1Sundstrom, J.
2Marcus, C.
3Hemmingsson, E.
4Neovius, M.
jtitleInternational Journal of Obesity
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Johansson, K.
1Sundstrom, J.
2Marcus, C.
3Hemmingsson, E.
4Neovius, M.
atitleRisk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study
jtitleInternational Journal of Obesity
risdate20140201
volume38
issue2
spage279
issn0307-0565
genrearticle
ristypeJOUR
abstractBACKGROUND: Concern exists regarding gallstones as an adverse event of very-low-calorie diets (VLCDs;< 800 kcal per day). OBJECTIVE: To assess the risk of symptomatic gallstones requiring hospital care and/or cholecystectomy in a commercial weight loss program using VLCD or low-calorie diet (LCD). DESIGN: A 1-year matched cohort study of consecutively enrolled adults in a commercial weight loss program conducted at 28 Swedish centers between 2006 and 2009. A 3-month weight loss phase of VLCD (500 kcal per day) or LCD (1200-1500 kcal per day) was followed by a 9-month weight maintenance phase. Matching (1:1) was performed by age, sex, body mass index, waist circumference and gallstone history (n = 3320:3320). Gallstone and cholecystectomy data were retrieved from the Swedish National Patient Register. RESULTS: One-year weight loss was greater in the VLCD than in the LCD group (-11.1 versus -8.1 kg; adjusted difference, - 2.8kg, 95% CI -3.1 to -2.4;P<0.001). During 6361 person-years, 48 and 14 gallstones requiring hospital care occurred in the VLCD and LCD groups, respectively, (152 versus 44/10000 person-years;hazard ratio, 3.4, 95% CI 1.8-6.3; P<0.001; number-needed-to-harm, 92, 95% CI 63-168;P<0.001). Of the 62 gallstone events, 38 (61%) resulted in cholecystectomy (29 versus 9; hazard ratio, 3.2, 95% CI 1.5-6.8;P = 0.003;number-needed-to-harm, 151, 95% CI 94-377;P<0.001). Adjusting for 3-month weight loss attenuated the hazard ratios, but the risk remained higher with VLCD than LCD for gallstones (2.5, 95% CI 1.3-5.1;P = 0.009) and became borderline for cholecystectomy (2.2, 95% CI 0.9-5.2;P = 0.08). CONCLUSION: The risk of symptomatic gallstones requiring hospitalization or cholecystectomy, albeit low, was 3-fold greater with VLCD than LCD during the 1-year commercial weight loss program. International Journal of Obesity (2014) 38, 279-284; doi:10.1038/ijo.2013.83 Keywords: VLCD; LCD; commercial weight loss; gallstones; cholecystectomy; adverse events
pubNature Publishing Group
doi10.1038/ijo.2013.83
lad01gale_hrca
pages279-284
eissn14765497
date2014-02-01