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Role(s) of Leader protein of Saffold virus.(Report)

Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments. Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient c... Full description

Journal Title: Clinical and Experimental Neuroimmunology Oct, 2014, Vol.5(3), p.362(5)
Main Author: Shimizu, Ai
Other Authors: Himeda, Toshiki , Okuwa, Takako , Muraki, Yasushi , Ohara, Yoshiro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1759-1961
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recordid: gale_hrca397932391
title: Role(s) of Leader protein of Saffold virus.(Report)
format: Article
creator:
  • Shimizu, Ai
  • Himeda, Toshiki
  • Okuwa, Takako
  • Muraki, Yasushi
  • Ohara, Yoshiro
subjects:
  • Biological Response Modifiers -- Health Aspects
  • Biological Response Modifiers -- Analysis
ispartof: Clinical and Experimental Neuroimmunology, Oct, 2014, Vol.5(3), p.362(5)
description: Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments. Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient clinic of Tohoku University Hospital. The study group included 47 patients (47 eyes) who underwent glaucoma surgery: trabeculectomy, trabeculotomy, and trabectome surgery. The analysis used Kaplan-Meier life tables, with surgical failure defined as intraocular pressure [??]21 mmHg or the need for additional glaucoma surgery. Results: UG patients represented 9.73% of our database of glaucoma patients. The mean follow-up period was 40.32 [+ or -] 32.53 months. Seventy-one patients had granulomatous uveitis (67.62%) and 34 had nongranulomatous uveitis (32.38%). The causes of uveitis included sarcoidosis (n=25), Behcet's disease (n=11), Vogt-Koyanagi-Harada disease (n=9), Posner-Schlossman syndrome (n=12), herpes simplex virus infectious uveitis (n=7), acute anterior uveitis (n=5), intermediate uveitis (n=4), scleritis (n=4), inflammatory bowel disease (n=4), varicella zoster virus uveitis (n=2), and others (n=6). An additional 16 patients were diagnosed with idiopathic UG. Surgical success rates were 82.86% for trabeculectomy, 62.50% for trabeculotomy, and 75.00% for trabectome. Significant risk factors for surgical failure included male sex (P=0.02), age less than 45 years (P=0.0009), nongranulomatous uveitis (P=0.04), and postoperative inflammation (P=0.01). Conclusion: Young male patients with nongranulomatous uveitis had a significant risk of surgical failure. Moreover, prolonged postoperative inflammation created a susceptibility to surgical failure, indicating the importance of postoperative inflammation reduction. Keywords: uveitic glaucoma, sarcoidosis, Behcet's disease
language: English
source:
identifier: ISSN: 1759-1961
fulltext: fulltext
issn:
  • 1759-1961
  • 17591961
url: Link


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titleRole(s) of Leader protein of Saffold virus.(Report)
creatorShimizu, Ai ; Himeda, Toshiki ; Okuwa, Takako ; Muraki, Yasushi ; Ohara, Yoshiro
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descriptionPurpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments. Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient clinic of Tohoku University Hospital. The study group included 47 patients (47 eyes) who underwent glaucoma surgery: trabeculectomy, trabeculotomy, and trabectome surgery. The analysis used Kaplan-Meier life tables, with surgical failure defined as intraocular pressure [??]21 mmHg or the need for additional glaucoma surgery. Results: UG patients represented 9.73% of our database of glaucoma patients. The mean follow-up period was 40.32 [+ or -] 32.53 months. Seventy-one patients had granulomatous uveitis (67.62%) and 34 had nongranulomatous uveitis (32.38%). The causes of uveitis included sarcoidosis (n=25), Behcet's disease (n=11), Vogt-Koyanagi-Harada disease (n=9), Posner-Schlossman syndrome (n=12), herpes simplex virus infectious uveitis (n=7), acute anterior uveitis (n=5), intermediate uveitis (n=4), scleritis (n=4), inflammatory bowel disease (n=4), varicella zoster virus uveitis (n=2), and others (n=6). An additional 16 patients were diagnosed with idiopathic UG. Surgical success rates were 82.86% for trabeculectomy, 62.50% for trabeculotomy, and 75.00% for trabectome. Significant risk factors for surgical failure included male sex (P=0.02), age less than 45 years (P=0.0009), nongranulomatous uveitis (P=0.04), and postoperative inflammation (P=0.01). Conclusion: Young male patients with nongranulomatous uveitis had a significant risk of surgical failure. Moreover, prolonged postoperative inflammation created a susceptibility to surgical failure, indicating the importance of postoperative inflammation reduction. Keywords: uveitic glaucoma, sarcoidosis, Behcet's disease
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