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Six and 12 weeks of caloric restriction increases [beta] cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes.(Report)(Author abstract)

Background: Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism: however, the mechanism by which this occurs remains uncertain. Objective: We sought to quantify the effect of caloric restriction on [beta] cell function and glucose metabolism in people wi... Full description

Journal Title: The Journal of Nutrition Sept, 2015, Vol.145(9), p.2046(6)
Main Author: Sathananthan, Matheni
Other Authors: Shah, Meera , Edens, Kim L. , Grothe, Karen B. , Piccinini, Francesca , Farrugia, Luca P. , Micheletto, Francesco , Man, Chiara Dalla , Cobelli, Claudio , Rizza, Robert A. , Camilleri, Michael , Vella, Adrian
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Language: English
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ID: ISSN: 0022-3166
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title: Six and 12 weeks of caloric restriction increases [beta] cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes.(Report)(Author abstract)
format: Article
creator:
  • Sathananthan, Matheni
  • Shah, Meera
  • Edens, Kim L.
  • Grothe, Karen B.
  • Piccinini, Francesca
  • Farrugia, Luca P.
  • Micheletto, Francesco
  • Man, Chiara Dalla
  • Cobelli, Claudio
  • Rizza, Robert A.
  • Camilleri, Michael
  • Vella, Adrian
subjects:
  • Type 2 Diabetes -- Care And Treatment
  • Low Calorie Diet -- Health Aspects
  • Glucose Metabolism -- Methods
ispartof: The Journal of Nutrition, Sept, 2015, Vol.145(9), p.2046(6)
description: Background: Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism: however, the mechanism by which this occurs remains uncertain. Objective: We sought to quantify the effect of caloric restriction on [beta] cell function and glucose metabolism in people with type 2 diabetes. Methods: Nine subjects (2 men, 7 women) with type 2 diabetes [BMI (in kg/[m.sup.2]): 40.6 [+ or -] 1.4; age: 58 [+ or -] 3 y; glycated hemoglobin: 6.9% [+ or -] 0.2%] were studied using a triple-tracer mixed meal after withdrawal of oral diabetes therapy. The oral minimal model was used to measure [beta] cell function. Caloric restriction limited subjects to a pureed diet (
language: English
source:
identifier: ISSN: 0022-3166
fulltext: fulltext
issn:
  • 0022-3166
  • 00223166
url: Link


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titleSix and 12 weeks of caloric restriction increases [beta] cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes.(Report)(Author abstract)
creatorSathananthan, Matheni ; Shah, Meera ; Edens, Kim L. ; Grothe, Karen B. ; Piccinini, Francesca ; Farrugia, Luca P. ; Micheletto, Francesco ; Man, Chiara Dalla ; Cobelli, Claudio ; Rizza, Robert A. ; Camilleri, Michael ; Vella, Adrian
ispartofThe Journal of Nutrition, Sept, 2015, Vol.145(9), p.2046(6)
identifierISSN: 0022-3166
subjectType 2 Diabetes -- Care And Treatment ; Low Calorie Diet -- Health Aspects ; Glucose Metabolism -- Methods
descriptionBackground: Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism: however, the mechanism by which this occurs remains uncertain. Objective: We sought to quantify the effect of caloric restriction on [beta] cell function and glucose metabolism in people with type 2 diabetes. Methods: Nine subjects (2 men, 7 women) with type 2 diabetes [BMI (in kg/[m.sup.2]): 40.6 [+ or -] 1.4; age: 58 [+ or -] 3 y; glycated hemoglobin: 6.9% [+ or -] 0.2%] were studied using a triple-tracer mixed meal after withdrawal of oral diabetes therapy. The oral minimal model was used to measure [beta] cell function. Caloric restriction limited subjects to a pureed diet ( <900 kcal/d) for the 12 wk of study. The studies were repeated after 6 and 12 wk of caloric restriction. Results: Fasting glucose concentrations decreased significantly from baseline after 6 wk of caloric restriction with no further reduction after a further 6 wk of caloric restriction (9.8 [+ or -] 1.3, 5.9 [+ or -] 0.2, and 6.2 [+ or -] 0.3 mmol/L at baseline and after 6 and 12 wk of caloric restriction, respectively: P = 0.01) because of decreased fasting endogenous glucose production (EGP: 20.4 [+ or -] 1.1, 16.2 [+ or -] 0.8, and 17.4 [+ or -] 1.1 [micro] mol x [kg.sup.-1] x [min.sup.-1] at baseline and after 6 and 12 wk of caloric restriction, respectively: P = 0.03). These changes were accompanied by an improvement in p cell function measured by the disposition index (189 [+ or -] 51,436 [+ or -] 68, and 449 [+ or -] 67 [10.sup.-14] dL x [kg.sup.-1] x [min.sup.-2] x [pmol.sup.-1] at baseline and after 6 and 12 wk of caloric restriction, respectively: P= 0.01). Conclusions: Six weeks of caloric restriction lowers fasting glucose and EGP with accompanying improvements in |3 cell function in people with type 2 diabetes. An additional 6 wk of caloric restriction maintained the improvement in glucose metabolism. This trial was registered at clinicaltrials.gov as NCT01094054. Keywords: caloric restriction, endogenous glucose production, bariatric surgery, gastric emptying, insulin secretion, insulin action, disposition index doi: 10.3945/jn.115.210617
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2Shah, Meera
3Edens, Kim L
4Grothe, Karen B
5Piccinini, Francesca
6Farrugia, Luca P
7Micheletto, Francesco
8Man, Chiara Dalla
9Cobelli, Claudio
10Rizza, Robert A
11Camilleri, Michael
12Vella, Adrian
titleSix and 12 weeks of caloric restriction increases [beta] cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes.(Report)(Author abstract)
descriptionBackground: Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism: however, the mechanism by which this occurs remains uncertain. Objective: We sought to quantify the effect of caloric restriction on [beta] cell function and glucose metabolism in people with type 2 diabetes. Methods: Nine subjects (2 men, 7 women) with type 2 diabetes [BMI (in kg/[m.sup.2]): 40.6 [+ or -] 1.4; age: 58 [+ or -] 3 y; glycated hemoglobin: 6.9% [+ or -] 0.2%] were studied using a triple-tracer mixed meal after withdrawal of oral diabetes therapy. The oral minimal model was used to measure [beta] cell function. Caloric restriction limited subjects to a pureed diet ( <900 kcal/d) for the 12 wk of study. The studies were repeated after 6 and 12 wk of caloric restriction. Results: Fasting glucose concentrations decreased significantly from baseline after 6 wk of caloric restriction with no further reduction after a further 6 wk of caloric restriction (9.8 [+ or -] 1.3, 5.9 [+ or -] 0.2, and 6.2 [+ or -] 0.3 mmol/L at baseline and after 6 and 12 wk of caloric restriction, respectively: P = 0.01) because of decreased fasting endogenous glucose production (EGP: 20.4 [+ or -] 1.1, 16.2 [+ or -] 0.8, and 17.4 [+ or -] 1.1 [micro] mol x [kg.sup.-1] x [min.sup.-1] at baseline and after 6 and 12 wk of caloric restriction, respectively: P = 0.03). These changes were accompanied by an improvement in p cell function measured by the disposition index (189 [+ or -] 51,436 [+ or -] 68, and 449 [+ or -] 67 [10.sup.-14] dL x [kg.sup.-1] x [min.sup.-2] x [pmol.sup.-1] at baseline and after 6 and 12 wk of caloric restriction, respectively: P= 0.01). Conclusions: Six weeks of caloric restriction lowers fasting glucose and EGP with accompanying improvements in |3 cell function in people with type 2 diabetes. An additional 6 wk of caloric restriction maintained the improvement in glucose metabolism. This trial was registered at clinicaltrials.gov as NCT01094054. Keywords: caloric restriction, endogenous glucose production, bariatric surgery, gastric emptying, insulin secretion, insulin action, disposition index doi: 10.3945/jn.115.210617
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titleSix and 12 weeks of caloric restriction increases [beta] cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes.(Report)(Author abstract)
authorSathananthan, Matheni ; Shah, Meera ; Edens, Kim L. ; Grothe, Karen B. ; Piccinini, Francesca ; Farrugia, Luca P. ; Micheletto, Francesco ; Man, Chiara Dalla ; Cobelli, Claudio ; Rizza, Robert A. ; Camilleri, Michael ; Vella, Adrian
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4Piccinini, Francesca
5Farrugia, Luca P.
6Micheletto, Francesco
7Man, Chiara Dalla
8Cobelli, Claudio
9Rizza, Robert A.
10Camilleri, Michael
11Vella, Adrian
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1Shah, Meera
2Edens, Kim L.
3Grothe, Karen B.
4Piccinini, Francesca
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6Micheletto, Francesco
7Man, Chiara Dalla
8Cobelli, Claudio
9Rizza, Robert A.
10Camilleri, Michael
11Vella, Adrian
atitleSix and 12 weeks of caloric restriction increases [beta] cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes
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abstractBackground: Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism: however, the mechanism by which this occurs remains uncertain. Objective: We sought to quantify the effect of caloric restriction on [beta] cell function and glucose metabolism in people with type 2 diabetes. Methods: Nine subjects (2 men, 7 women) with type 2 diabetes [BMI (in kg/[m.sup.2]): 40.6 [+ or -] 1.4; age: 58 [+ or -] 3 y; glycated hemoglobin: 6.9% [+ or -] 0.2%] were studied using a triple-tracer mixed meal after withdrawal of oral diabetes therapy. The oral minimal model was used to measure [beta] cell function. Caloric restriction limited subjects to a pureed diet ( <900 kcal/d) for the 12 wk of study. The studies were repeated after 6 and 12 wk of caloric restriction. Results: Fasting glucose concentrations decreased significantly from baseline after 6 wk of caloric restriction with no further reduction after a further 6 wk of caloric restriction (9.8 [+ or -] 1.3, 5.9 [+ or -] 0.2, and 6.2 [+ or -] 0.3 mmol/L at baseline and after 6 and 12 wk of caloric restriction, respectively: P = 0.01) because of decreased fasting endogenous glucose production (EGP: 20.4 [+ or -] 1.1, 16.2 [+ or -] 0.8, and 17.4 [+ or -] 1.1 [micro] mol x [kg.sup.-1] x [min.sup.-1] at baseline and after 6 and 12 wk of caloric restriction, respectively: P = 0.03). These changes were accompanied by an improvement in p cell function measured by the disposition index (189 [+ or -] 51,436 [+ or -] 68, and 449 [+ or -] 67 [10.sup.-14] dL x [kg.sup.-1] x [min.sup.-2] x [pmol.sup.-1] at baseline and after 6 and 12 wk of caloric restriction, respectively: P= 0.01). Conclusions: Six weeks of caloric restriction lowers fasting glucose and EGP with accompanying improvements in |3 cell function in people with type 2 diabetes. An additional 6 wk of caloric restriction maintained the improvement in glucose metabolism. This trial was registered at clinicaltrials.gov as NCT01094054. Keywords: caloric restriction, endogenous glucose production, bariatric surgery, gastric emptying, insulin secretion, insulin action, disposition index doi: 10.3945/jn.115.210617
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