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Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging.(Research Article)

Targeted delivery of drugs to tumors represents a significant advance in cancer diagnosis and therapy. Therefore, development of novel tumor-specific ligands or pharmaceutical nanocarriers is highly desirable. In this study, we utilized phage display to identify a new targeting peptide, SP90, which... Full description

Journal Title: PLoS ONE June 11, 2013, Vol.8(6), p.e66128
Main Author: Lu, Ruei - Min
Other Authors: Chen, Min - Shan , Chang, De - Kuan , Chiu, Chien - Yu , Lin, Wei - Chuan , Yan, Shin - Long , Wang, Yi - Ping , Kuo, Yuan - Sung , Yeh, Chen - Yun , Lo, Albert , Wu, Han - Chung
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0066128
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recordid: gale_hrca478325693
title: Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging.(Research Article)
format: Article
creator:
  • Lu, Ruei - Min
  • Chen, Min - Shan
  • Chang, De - Kuan
  • Chiu, Chien - Yu
  • Lin, Wei - Chuan
  • Yan, Shin - Long
  • Wang, Yi - Ping
  • Kuo, Yuan - Sung
  • Yeh, Chen - Yun
  • Lo, Albert
  • Wu, Han - Chung
subjects:
  • Peptides -- Health Aspects
  • Breast Cancer -- Health Aspects
  • Drugs -- Health Aspects
  • Anthracyclines -- Health Aspects
  • Drug Delivery Systems -- Health Aspects
  • Chemotherapy -- Health Aspects
ispartof: PLoS ONE, June 11, 2013, Vol.8(6), p.e66128
description: Targeted delivery of drugs to tumors represents a significant advance in cancer diagnosis and therapy. Therefore, development of novel tumor-specific ligands or pharmaceutical nanocarriers is highly desirable. In this study, we utilized phage display to identify a new targeting peptide, SP90, which specifically binds to breast cancer cells, and recognizes tumor tissues from breast cancer patients. We used confocal and electron microscopy to reveal that conjugation of SP90 with liposomes enables efficient delivery of drugs into cancer cells through endocytosis. Furthermore, in vivo fluorescent imaging demonstrated that SP90-conjugated quantum dots possess tumor-targeting properties. In tumor xenograft and orthotopic models, SP90-conjugated liposomal doxorubicin was found to improve the therapeutic index of the chemotherapeutic drug by selectively increasing its accumulation in tumors. We conclude that the targeting peptide SP90 has significant potential in improving the clinical benefits of chemotherapy in the treatment and the diagnosis of breast cancer.
language: English
source:
identifier: ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0066128
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleTargeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging.(Research Article)
creatorLu, Ruei - Min ; Chen, Min - Shan ; Chang, De - Kuan ; Chiu, Chien - Yu ; Lin, Wei - Chuan ; Yan, Shin - Long ; Wang, Yi - Ping ; Kuo, Yuan - Sung ; Yeh, Chen - Yun ; Lo, Albert ; Wu, Han - Chung
ispartofPLoS ONE, June 11, 2013, Vol.8(6), p.e66128
identifierISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0066128
subjectPeptides -- Health Aspects ; Breast Cancer -- Health Aspects ; Drugs -- Health Aspects ; Anthracyclines -- Health Aspects ; Drug Delivery Systems -- Health Aspects ; Chemotherapy -- Health Aspects
descriptionTargeted delivery of drugs to tumors represents a significant advance in cancer diagnosis and therapy. Therefore, development of novel tumor-specific ligands or pharmaceutical nanocarriers is highly desirable. In this study, we utilized phage display to identify a new targeting peptide, SP90, which specifically binds to breast cancer cells, and recognizes tumor tissues from breast cancer patients. We used confocal and electron microscopy to reveal that conjugation of SP90 with liposomes enables efficient delivery of drugs into cancer cells through endocytosis. Furthermore, in vivo fluorescent imaging demonstrated that SP90-conjugated quantum dots possess tumor-targeting properties. In tumor xenograft and orthotopic models, SP90-conjugated liposomal doxorubicin was found to improve the therapeutic index of the chemotherapeutic drug by selectively increasing its accumulation in tumors. We conclude that the targeting peptide SP90 has significant potential in improving the clinical benefits of chemotherapy in the treatment and the diagnosis of breast cancer.
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titleTargeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging.(Research Article)
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titleTargeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging.(Research Article)
authorLu, Ruei - Min ; Chen, Min - Shan ; Chang, De - Kuan ; Chiu, Chien - Yu ; Lin, Wei - Chuan ; Yan, Shin - Long ; Wang, Yi - Ping ; Kuo, Yuan - Sung ; Yeh, Chen - Yun ; Lo, Albert ; Wu, Han - Chung
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abstractTargeted delivery of drugs to tumors represents a significant advance in cancer diagnosis and therapy. Therefore, development of novel tumor-specific ligands or pharmaceutical nanocarriers is highly desirable. In this study, we utilized phage display to identify a new targeting peptide, SP90, which specifically binds to breast cancer cells, and recognizes tumor tissues from breast cancer patients. We used confocal and electron microscopy to reveal that conjugation of SP90 with liposomes enables efficient delivery of drugs into cancer cells through endocytosis. Furthermore, in vivo fluorescent imaging demonstrated that SP90-conjugated quantum dots possess tumor-targeting properties. In tumor xenograft and orthotopic models, SP90-conjugated liposomal doxorubicin was found to improve the therapeutic index of the chemotherapeutic drug by selectively increasing its accumulation in tumors. We conclude that the targeting peptide SP90 has significant potential in improving the clinical benefits of chemotherapy in the treatment and the diagnosis of breast cancer.
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