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Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.(Original Article)(Report)(Author abstract)

Rapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds to nutrient availability, seemingly mimics the effects of caloric restriction (CR) on healthy life span. However, the extent of the mechanistic overlap between RM and CR remains incompletely understo... Full description

Journal Title: The Journals of Gerontology Series A, Jan, 2018, Vol.73(1), p.29(10)
Main Author: Choi, Kyung - Mi
Other Authors: Hong, Seok - Jin , Van Deursen, Jan M. , Kim, Sooah , Kim, Kyoung Heon , Lee, Cheol - Koo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1079-5006 ; DOI: 10.1093/gerona/glx024
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recordid: gale_hrca523062253
title: Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.(Original Article)(Report)(Author abstract)
format: Article
creator:
  • Choi, Kyung - Mi
  • Hong, Seok - Jin
  • Van Deursen, Jan M.
  • Kim, Sooah
  • Kim, Kyoung Heon
  • Lee, Cheol - Koo
subjects:
  • Low Calorie Diet -- Research
  • Rapamycin -- Research
  • Cytological Research
ispartof: The Journals of Gerontology, Series A, Jan, 2018, Vol.73(1), p.29(10)
description: Rapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds to nutrient availability, seemingly mimics the effects of caloric restriction (CR) on healthy life span. However, the extent of the mechanistic overlap between RM and CR remains incompletely understood. Here, we compared the impact of CR and RM on cellular metabolic status. Both regimens maintained intracellular ATP through the chronological aging process and showed enhanced mitochondrial capacity. Comparative transcriptome analysis showed that CR had a stronger impact on global gene expression than RM. We observed a like impact on the metabolome and identified distinct metabolites affected by CR and RM. CR severely reduced the level of energy storage molecules including glycogen and lipid droplets, whereas RM did not. RM boosted the production of enzymes responsible for the breakdown of glycogen and lipid droplets. Collectively, these results provide insights into the distinct energy metabolism mechanisms induced by CR and RM, suggesting that these two anti- aging regimens might extend life span through distinctive pathways. Keywords: Transcriptomics--Metabolomics doi:10.1093/gerona/glx024
language: English
source:
identifier: ISSN: 1079-5006 ; DOI: 10.1093/gerona/glx024
fulltext: no_fulltext
issn:
  • 1079-5006
  • 10795006
url: Link


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titleCaloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.(Original Article)(Report)(Author abstract)
creatorChoi, Kyung - Mi ; Hong, Seok - Jin ; Van Deursen, Jan M. ; Kim, Sooah ; Kim, Kyoung Heon ; Lee, Cheol - Koo
ispartofThe Journals of Gerontology, Series A, Jan, 2018, Vol.73(1), p.29(10)
identifierISSN: 1079-5006 ; DOI: 10.1093/gerona/glx024
subjectLow Calorie Diet -- Research ; Rapamycin -- Research ; Cytological Research
descriptionRapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds to nutrient availability, seemingly mimics the effects of caloric restriction (CR) on healthy life span. However, the extent of the mechanistic overlap between RM and CR remains incompletely understood. Here, we compared the impact of CR and RM on cellular metabolic status. Both regimens maintained intracellular ATP through the chronological aging process and showed enhanced mitochondrial capacity. Comparative transcriptome analysis showed that CR had a stronger impact on global gene expression than RM. We observed a like impact on the metabolome and identified distinct metabolites affected by CR and RM. CR severely reduced the level of energy storage molecules including glycogen and lipid droplets, whereas RM did not. RM boosted the production of enzymes responsible for the breakdown of glycogen and lipid droplets. Collectively, these results provide insights into the distinct energy metabolism mechanisms induced by CR and RM, suggesting that these two anti- aging regimens might extend life span through distinctive pathways. Keywords: Transcriptomics--Metabolomics doi:10.1093/gerona/glx024
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titleCaloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.(Original Article)(Report)(Author abstract)
descriptionRapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds to nutrient availability, seemingly mimics the effects of caloric restriction (CR) on healthy life span. However, the extent of the mechanistic overlap between RM and CR remains incompletely understood. Here, we compared the impact of CR and RM on cellular metabolic status. Both regimens maintained intracellular ATP through the chronological aging process and showed enhanced mitochondrial capacity. Comparative transcriptome analysis showed that CR had a stronger impact on global gene expression than RM. We observed a like impact on the metabolome and identified distinct metabolites affected by CR and RM. CR severely reduced the level of energy storage molecules including glycogen and lipid droplets, whereas RM did not. RM boosted the production of enzymes responsible for the breakdown of glycogen and lipid droplets. Collectively, these results provide insights into the distinct energy metabolism mechanisms induced by CR and RM, suggesting that these two anti- aging regimens might extend life span through distinctive pathways. Keywords: Transcriptomics--Metabolomics doi:10.1093/gerona/glx024
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titleCaloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.(Original Article)(Report)(Author abstract)
authorChoi, Kyung - Mi ; Hong, Seok - Jin ; Van Deursen, Jan M. ; Kim, Sooah ; Kim, Kyoung Heon ; Lee, Cheol - Koo
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abstractRapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds to nutrient availability, seemingly mimics the effects of caloric restriction (CR) on healthy life span. However, the extent of the mechanistic overlap between RM and CR remains incompletely understood. Here, we compared the impact of CR and RM on cellular metabolic status. Both regimens maintained intracellular ATP through the chronological aging process and showed enhanced mitochondrial capacity. Comparative transcriptome analysis showed that CR had a stronger impact on global gene expression than RM. We observed a like impact on the metabolome and identified distinct metabolites affected by CR and RM. CR severely reduced the level of energy storage molecules including glycogen and lipid droplets, whereas RM did not. RM boosted the production of enzymes responsible for the breakdown of glycogen and lipid droplets. Collectively, these results provide insights into the distinct energy metabolism mechanisms induced by CR and RM, suggesting that these two anti- aging regimens might extend life span through distinctive pathways. Keywords: Transcriptomics--Metabolomics doi:10.1093/gerona/glx024
pubGerontological Society of America
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