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Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer.(Brief article)

HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA that has been shown to be a key regulator of myeloid cell development by targeting HOXA1. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that possess immunosuppress... Full description

Journal Title: Frontiers in Immunology March 12, 2018
Main Author: Tian, Xinyu
Other Authors: Ma, Jie , Wang, Ting , Tian, Jie , Zhang, Yue , Mao, Lingxiang , Xu, Huaxi , Wang, Shengjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1664-3224 ; DOI: 10.3389/fimmu.2018.00473
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recordid: gale_hrca530667234
title: Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer.(Brief article)
format: Article
creator:
  • Tian, Xinyu
  • Ma, Jie
  • Wang, Ting
  • Tian, Jie
  • Zhang, Yue
  • Mao, Lingxiang
  • Xu, Huaxi
  • Wang, Shengjun
subjects:
  • Gene Expression -- Physiological Aspects
  • Gene Expression -- Research
  • Antisense Rna -- Physiological Aspects
  • Antisense Rna -- Research
  • Lung Cancer -- Research
  • Lung Cancer -- Genetic Aspects
  • Lung Cancer -- Care And Treatment
  • Lung Cancer -- Development And Progression
ispartof: Frontiers in Immunology, March 12, 2018
description: HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA that has been shown to be a key regulator of myeloid cell development by targeting HOXA1. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that possess immunosuppressive function. However, the impact of HOTAIRM1 on the development of MDSCs remains unknown. In this study, we demonstrated that HOTAIRM1 was expressed in MDSCs and that overexpression of HOTAIRM1 could downregulate the expression of suppressive molecules in MDSCs. In addition, HOTAIRM1 levels were observed to be decreased in the peripheral blood cells of lung cancer patients compared with those of healthy controls. By analyzing HOTAIRM1 expression levels in different types of lung cancer, we found that HOTAIRM1 was mainly expressed in lung adenocarcinoma. Finally, it was confirmed that HOTAIRM1 could enhance the expression of HOXA1 in MDSCs and that high levels of HOXA1, the target gene of HOTAIRM1, could delay tumor progression and enhance the antitumor immune response by downregulating the immunosuppression of MDSCs. Taken together, this study illustrates that HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a potential therapeutic target in lung cancer.
language: English
source:
identifier: ISSN: 1664-3224 ; DOI: 10.3389/fimmu.2018.00473
fulltext: fulltext
issn:
  • 1664-3224
  • 16643224
url: Link


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titleLong Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer.(Brief article)
creatorTian, Xinyu ; Ma, Jie ; Wang, Ting ; Tian, Jie ; Zhang, Yue ; Mao, Lingxiang ; Xu, Huaxi ; Wang, Shengjun
ispartofFrontiers in Immunology, March 12, 2018
identifierISSN: 1664-3224 ; DOI: 10.3389/fimmu.2018.00473
subjectGene Expression -- Physiological Aspects ; Gene Expression -- Research ; Antisense Rna -- Physiological Aspects ; Antisense Rna -- Research ; Lung Cancer -- Research ; Lung Cancer -- Genetic Aspects ; Lung Cancer -- Care And Treatment ; Lung Cancer -- Development And Progression
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descriptionHOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA that has been shown to be a key regulator of myeloid cell development by targeting HOXA1. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that possess immunosuppressive function. However, the impact of HOTAIRM1 on the development of MDSCs remains unknown. In this study, we demonstrated that HOTAIRM1 was expressed in MDSCs and that overexpression of HOTAIRM1 could downregulate the expression of suppressive molecules in MDSCs. In addition, HOTAIRM1 levels were observed to be decreased in the peripheral blood cells of lung cancer patients compared with those of healthy controls. By analyzing HOTAIRM1 expression levels in different types of lung cancer, we found that HOTAIRM1 was mainly expressed in lung adenocarcinoma. Finally, it was confirmed that HOTAIRM1 could enhance the expression of HOXA1 in MDSCs and that high levels of HOXA1, the target gene of HOTAIRM1, could delay tumor progression and enhance the antitumor immune response by downregulating the immunosuppression of MDSCs. Taken together, this study illustrates that HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a potential therapeutic target in lung cancer.
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titleLong Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer.(Brief article)
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