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Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.(Report)

Background Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut con... Full description

Journal Title: BMC Medicine July 16, 2013, Vol.11(1)
Main Author: Guasch - Ferrn, Marta
Other Authors: Bullo, Ma[Sup. 2]Nica , Martinez - Gonzalez, Miguel Angel , Ros, Emilio , Corella, Dolores , Estruch, Ramon , Fito, Montserrat , Aros, Fernando , Warnberg, Julia , Fiol, Miquel , Lapetra, Josn , Vinyoles, Ernest , Lamuela - Raventos, Rosa Maria , Serra - Majem, Lluis , Pinto, Xavier , Ruiz - Gutinrrez, Valentina , Basora, Josep , Salas - Salvado, Jordi
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 1741-7015 ; DOI: 10.1186/1741-7015-11-164
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recordid: gale_hrca534638003
title: Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.(Report)
format: Article
creator:
  • Guasch - Ferrn, Marta
  • Bullo, Ma[Sup. 2]Nica
  • Martinez - Gonzalez, Miguel Angel
  • Ros, Emilio
  • Corella, Dolores
  • Estruch, Ramon
  • Fito, Montserrat
  • Aros, Fernando
  • Warnberg, Julia
  • Fiol, Miquel
  • Lapetra, Josn
  • Vinyoles, Ernest
  • Lamuela - Raventos, Rosa Maria
  • Serra - Majem, Lluis
  • Pinto, Xavier
  • Ruiz - Gutinrrez, Valentina
  • Basora, Josep
  • Salas - Salvado, Jordi
subjects:
  • Mediterranean Diet -- Health Aspects
  • Nut Industry -- Health Aspects
  • Medical Records -- Health Aspects
  • Coronary Heart Disease -- Diet Therapy
  • Coronary Heart Disease -- Health Aspects
  • Cancer Prevention -- Health Aspects
  • Nuts (Food) -- Health Aspects
  • Olive Oil -- Health Aspects
  • Cancer Research -- Health Aspects
  • Mortality -- Spain
ispartof: BMC Medicine, July 16, 2013, Vol.11(1)
description: Background Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. Methods We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvenci#243;n con DIeta MEDiterr#225;nea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. Results During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend 0.05, all). Compared to non-consumers, subjects consuming nuts 3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts >3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). Conclusions Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. Trial registration Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. Keywords: Cancer, Cardiovascular, Mortality, Nuts, PREDIMED study
language: English
source:
identifier: ISSN: 1741-7015 ; DOI: 10.1186/1741-7015-11-164
fulltext: fulltext
issn:
  • 1741-7015
  • 17417015
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titleFrequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.(Report)
creatorGuasch - Ferrn, Marta ; Bullo, Ma[Sup. 2]Nica ; Martinez - Gonzalez, Miguel Angel ; Ros, Emilio ; Corella, Dolores ; Estruch, Ramon ; Fito, Montserrat ; Aros, Fernando ; Warnberg, Julia ; Fiol, Miquel ; Lapetra, Josn ; Vinyoles, Ernest ; Lamuela - Raventos, Rosa Maria ; Serra - Majem, Lluis ; Pinto, Xavier ; Ruiz - Gutinrrez, Valentina ; Basora, Josep ; Salas - Salvado, Jordi
ispartofBMC Medicine, July 16, 2013, Vol.11(1)
identifierISSN: 1741-7015 ; DOI: 10.1186/1741-7015-11-164
subjectMediterranean Diet -- Health Aspects ; Nut Industry -- Health Aspects ; Medical Records -- Health Aspects ; Coronary Heart Disease -- Diet Therapy ; Coronary Heart Disease -- Health Aspects ; Cancer Prevention -- Health Aspects ; Nuts (Food) -- Health Aspects ; Olive Oil -- Health Aspects ; Cancer Research -- Health Aspects ; Mortality -- Spain
descriptionBackground Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. Methods We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvenci#243;n con DIeta MEDiterr#225;nea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. Results During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend 0.05, all). Compared to non-consumers, subjects consuming nuts 3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts >3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). Conclusions Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. Trial registration Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. Keywords: Cancer, Cardiovascular, Mortality, Nuts, PREDIMED study
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titleFrequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.(Report)
descriptionBackground Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. Methods We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvenci#243;n con DIeta MEDiterr#225;nea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. Results During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend 0.05, all). Compared to non-consumers, subjects consuming nuts 3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts >3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). Conclusions Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. Trial registration Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. Keywords: Cancer, Cardiovascular, Mortality, Nuts, PREDIMED study
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titleFrequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.(Report)
authorGuasch - Ferrn, Marta ; Bullo, Ma[Sup. 2]Nica ; Martinez - Gonzalez, Miguel Angel ; Ros, Emilio ; Corella, Dolores ; Estruch, Ramon ; Fito, Montserrat ; Aros, Fernando ; Warnberg, Julia ; Fiol, Miquel ; Lapetra, Josn ; Vinyoles, Ernest ; Lamuela - Raventos, Rosa Maria ; Serra - Majem, Lluis ; Pinto, Xavier ; Ruiz - Gutinrrez, Valentina ; Basora, Josep ; Salas - Salvado, Jordi
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6Fito, Montserrat
7Aros, Fernando
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12Lamuela-Raventos, Rosa Maria
13Serra-Majem, Lluis
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15Ruiz-Gutinrrez, Valentina
16Basora, Josep
17Salas-Salvado, Jordi
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abstractBackground Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. Methods We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvenci#243;n con DIeta MEDiterr#225;nea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. Results During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend 0.05, all). Compared to non-consumers, subjects consuming nuts 3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts >3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). Conclusions Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. Trial registration Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. Keywords: Cancer, Cardiovascular, Mortality, Nuts, PREDIMED study
pubBioMed Central Ltd.
doi10.1186/1741-7015-11-164
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pages164
date2013-07-16