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Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis

Background Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical me... Full description

Journal Title: BMC Infectious Diseases Jan 31, 2014, Vol.14(1)
Main Author: Wang, Chong
Other Authors: Li, Yan - Yuan , Li, Xiang , Wei, Li - Liang , Yang, Xiu - Yun , Xu, Dan - Dan , Jiang, Ting - Ting , Li, Zhong - Jie , Chen, Zhong - Liang , Zhang, Xing , Liu, Ji - Yan , Ping, Ze - Peng , Li, Ji - Cheng
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 1471-2334 ; DOI: 10.1186/1471-2334-14-52
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recordid: gale_hrca539576169
title: Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis
format: Article
creator:
  • Wang, Chong
  • Li, Yan - Yuan
  • Li, Xiang
  • Wei, Li - Liang
  • Yang, Xiu - Yun
  • Xu, Dan - Dan
  • Jiang, Ting - Ting
  • Li, Zhong - Jie
  • Chen, Zhong - Liang
  • Zhang, Xing
  • Liu, Ji - Yan
  • Ping, Ze - Peng
  • Li, Ji - Cheng
subjects:
  • Albumin -- Analysis
  • Albumin -- Health Aspects
  • Medical Research -- Analysis
  • Medical Research -- Health Aspects
  • Fibronectins -- Analysis
  • Fibronectins -- Health Aspects
ispartof: BMC Infectious Diseases, Jan 31, 2014, Vol.14(1)
description: Background Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b), fibronectin (FN), and prolidase (PEPD) were detected using the ELISA method among the control, minimal PTB, moderate PTB, and advanced PTB groups. Results We found significantly higher levels of serum C4b and PEPD (P = 0.018, P = 0.003), and significantly lower levels of serum FN (P 0.001) in PTB patients. Furthermore, the serum levels of 3 proteins were significantly different among 3 PTB groups. FN level was significantly higher in the moderate PTB group, compared with patients in the minimal and advanced PTB groups (P 0.05, P 0.01). PEPD level was significantly higher in the moderate PTB group, compared with the minimal PTB group (P 0.05). Analysis of clinical data showed that serum albumin, C-reactive protein (CRP), prealbumin, and C4 were significantly higher (P 0.05), while serum globulin was significantly lower in patients with PTB (P 0.001). A significant negative correlation was found between C4b and albumin, prealbumin. On the other hand, a significant positive correlation was found between C4b and globulin, CRP, PEPD, as well as between PEPD and CRP (P 0.05). Conclusions Our study showed that C4b, FN, and PEPD are associated with tissue damage, granuloma formation, and cavity formation, respectively, in patients with PTB. The present study provides a new experimental basis to understand the pathogenesis and pathological changes of PTB. Keywords: Serum, Pulmonary tuberculosis, Complement C4b, Fibronectin, Prolidase, Granuloma, Cavity
language: English
source:
identifier: ISSN: 1471-2334 ; DOI: 10.1186/1471-2334-14-52
fulltext: fulltext
issn:
  • 1471-2334
  • 14712334
url: Link


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titleSerum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis
creatorWang, Chong ; Li, Yan - Yuan ; Li, Xiang ; Wei, Li - Liang ; Yang, Xiu - Yun ; Xu, Dan - Dan ; Jiang, Ting - Ting ; Li, Zhong - Jie ; Chen, Zhong - Liang ; Zhang, Xing ; Liu, Ji - Yan ; Ping, Ze - Peng ; Li, Ji - Cheng
ispartofBMC Infectious Diseases, Jan 31, 2014, Vol.14(1)
identifierISSN: 1471-2334 ; DOI: 10.1186/1471-2334-14-52
subjectAlbumin -- Analysis ; Albumin -- Health Aspects ; Medical Research -- Analysis ; Medical Research -- Health Aspects ; Fibronectins -- Analysis ; Fibronectins -- Health Aspects
descriptionBackground Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b), fibronectin (FN), and prolidase (PEPD) were detected using the ELISA method among the control, minimal PTB, moderate PTB, and advanced PTB groups. Results We found significantly higher levels of serum C4b and PEPD (P = 0.018, P = 0.003), and significantly lower levels of serum FN (P 0.001) in PTB patients. Furthermore, the serum levels of 3 proteins were significantly different among 3 PTB groups. FN level was significantly higher in the moderate PTB group, compared with patients in the minimal and advanced PTB groups (P 0.05, P 0.01). PEPD level was significantly higher in the moderate PTB group, compared with the minimal PTB group (P 0.05). Analysis of clinical data showed that serum albumin, C-reactive protein (CRP), prealbumin, and C4 were significantly higher (P 0.05), while serum globulin was significantly lower in patients with PTB (P 0.001). A significant negative correlation was found between C4b and albumin, prealbumin. On the other hand, a significant positive correlation was found between C4b and globulin, CRP, PEPD, as well as between PEPD and CRP (P 0.05). Conclusions Our study showed that C4b, FN, and PEPD are associated with tissue damage, granuloma formation, and cavity formation, respectively, in patients with PTB. The present study provides a new experimental basis to understand the pathogenesis and pathological changes of PTB. Keywords: Serum, Pulmonary tuberculosis, Complement C4b, Fibronectin, Prolidase, Granuloma, Cavity
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titleSerum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis
descriptionBackground Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b), fibronectin (FN), and prolidase (PEPD) were detected using the ELISA method among the control, minimal PTB, moderate PTB, and advanced PTB groups. Results We found significantly higher levels of serum C4b and PEPD (P = 0.018, P = 0.003), and significantly lower levels of serum FN (P 0.001) in PTB patients. Furthermore, the serum levels of 3 proteins were significantly different among 3 PTB groups. FN level was significantly higher in the moderate PTB group, compared with patients in the minimal and advanced PTB groups (P 0.05, P 0.01). PEPD level was significantly higher in the moderate PTB group, compared with the minimal PTB group (P 0.05). Analysis of clinical data showed that serum albumin, C-reactive protein (CRP), prealbumin, and C4 were significantly higher (P 0.05), while serum globulin was significantly lower in patients with PTB (P 0.001). A significant negative correlation was found between C4b and albumin, prealbumin. On the other hand, a significant positive correlation was found between C4b and globulin, CRP, PEPD, as well as between PEPD and CRP (P 0.05). Conclusions Our study showed that C4b, FN, and PEPD are associated with tissue damage, granuloma formation, and cavity formation, respectively, in patients with PTB. The present study provides a new experimental basis to understand the pathogenesis and pathological changes of PTB. Keywords: Serum, Pulmonary tuberculosis, Complement C4b, Fibronectin, Prolidase, Granuloma, Cavity
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titleSerum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis
authorWang, Chong ; Li, Yan - Yuan ; Li, Xiang ; Wei, Li - Liang ; Yang, Xiu - Yun ; Xu, Dan - Dan ; Jiang, Ting - Ting ; Li, Zhong - Jie ; Chen, Zhong - Liang ; Zhang, Xing ; Liu, Ji - Yan ; Ping, Ze - Peng ; Li, Ji - Cheng
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abstractBackground Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases of pulmonary tuberculosis (PTB) were analyzed using statistical methods, while serum levels of complement C4b (C4b), fibronectin (FN), and prolidase (PEPD) were detected using the ELISA method among the control, minimal PTB, moderate PTB, and advanced PTB groups. Results We found significantly higher levels of serum C4b and PEPD (P = 0.018, P = 0.003), and significantly lower levels of serum FN (P 0.001) in PTB patients. Furthermore, the serum levels of 3 proteins were significantly different among 3 PTB groups. FN level was significantly higher in the moderate PTB group, compared with patients in the minimal and advanced PTB groups (P 0.05, P 0.01). PEPD level was significantly higher in the moderate PTB group, compared with the minimal PTB group (P 0.05). Analysis of clinical data showed that serum albumin, C-reactive protein (CRP), prealbumin, and C4 were significantly higher (P 0.05), while serum globulin was significantly lower in patients with PTB (P 0.001). A significant negative correlation was found between C4b and albumin, prealbumin. On the other hand, a significant positive correlation was found between C4b and globulin, CRP, PEPD, as well as between PEPD and CRP (P 0.05). Conclusions Our study showed that C4b, FN, and PEPD are associated with tissue damage, granuloma formation, and cavity formation, respectively, in patients with PTB. The present study provides a new experimental basis to understand the pathogenesis and pathological changes of PTB. Keywords: Serum, Pulmonary tuberculosis, Complement C4b, Fibronectin, Prolidase, Granuloma, Cavity
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