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Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms

Some well-established immunotherapy, radiotherapy, postoperation, anticancer drugs such as anthracyclines, antimetabolites, human epidermal growth factor receptor 2 blockers, tyrosine kinase inhibitors, alkylating agents, checkpoint inhibitors, and angiogenesis inhibitors, are significantly linked t... Full description

Journal Title: Frontiers in Pharmacology Oct 16, 2018
Main Author: Yang, Xinyu
Other Authors: Li, Xinye , Yuan, Mengchen , Tian, Chao , Yang, Yihan , Wang, Xiaofeng , Zhang, Xiaoyu , Sun, Yang , He, Tianmai , Han, Songjie , Chen, Guang , Liu, Nian , Gao, Yonghong , Hu, Dan , Xing, Yanwei , Shang, Hongcai
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1663-9812 ; DOI: 10.3389/fphar.2018.01058
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recordid: gale_hrca558461389
title: Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms
format: Article
creator:
  • Yang, Xinyu
  • Li, Xinye
  • Yuan, Mengchen
  • Tian, Chao
  • Yang, Yihan
  • Wang, Xiaofeng
  • Zhang, Xiaoyu
  • Sun, Yang
  • He, Tianmai
  • Han, Songjie
  • Chen, Guang
  • Liu, Nian
  • Gao, Yonghong
  • Hu, Dan
  • Xing, Yanwei
  • Shang, Hongcai
subjects:
  • Atrial Fibrillation -- Drug Therapy
  • Atrial Fibrillation -- Complications And Side Effects
  • Antineoplastic Agents -- Complications And Side Effects
  • Cancer Treatment
  • Heart
  • Cancer Research
ispartof: Frontiers in Pharmacology, Oct 16, 2018
description: Some well-established immunotherapy, radiotherapy, postoperation, anticancer drugs such as anthracyclines, antimetabolites, human epidermal growth factor receptor 2 blockers, tyrosine kinase inhibitors, alkylating agents, checkpoint inhibitors, and angiogenesis inhibitors, are significantly linked to cardiotoxicity. Cardiotoxicity is a common complication of several cancer treatments. Some studies observed complications of cardiac arrhythmia associated with the treatment of cancer, including atrial fibrillation (AF), supraventricular arrhythmias, and cardiac repolarization abnormalities. AF increases the risk of cardiovascular morbidity and mortality; it is associated with an almost doubled risk of mortality and a nearly 5-fold increase in the risk of stroke. The occurrence of AF is also usually researched in patients with advanced cancer and those undergoing active cancer treatments. During cancer treatments, the incidence rate of AF affects the prognosis of tumor treatment and challenges the treatment strategy. The present article is mainly focused on the cardiotoxicity of cancer treatments. In our review, we discuss these anticancer therapies and how they induce AF and consequently provide information on the precaution of AF during cancer treatment.
language: English
source:
identifier: ISSN: 1663-9812 ; DOI: 10.3389/fphar.2018.01058
fulltext: fulltext
issn:
  • 1663-9812
  • 16639812
url: Link


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titleAnticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms
creatorYang, Xinyu ; Li, Xinye ; Yuan, Mengchen ; Tian, Chao ; Yang, Yihan ; Wang, Xiaofeng ; Zhang, Xiaoyu ; Sun, Yang ; He, Tianmai ; Han, Songjie ; Chen, Guang ; Liu, Nian ; Gao, Yonghong ; Hu, Dan ; Xing, Yanwei ; Shang, Hongcai
ispartofFrontiers in Pharmacology, Oct 16, 2018
identifierISSN: 1663-9812 ; DOI: 10.3389/fphar.2018.01058
subjectAtrial Fibrillation -- Drug Therapy ; Atrial Fibrillation -- Complications And Side Effects ; Antineoplastic Agents -- Complications And Side Effects ; Cancer Treatment ; Heart ; Cancer Research
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descriptionSome well-established immunotherapy, radiotherapy, postoperation, anticancer drugs such as anthracyclines, antimetabolites, human epidermal growth factor receptor 2 blockers, tyrosine kinase inhibitors, alkylating agents, checkpoint inhibitors, and angiogenesis inhibitors, are significantly linked to cardiotoxicity. Cardiotoxicity is a common complication of several cancer treatments. Some studies observed complications of cardiac arrhythmia associated with the treatment of cancer, including atrial fibrillation (AF), supraventricular arrhythmias, and cardiac repolarization abnormalities. AF increases the risk of cardiovascular morbidity and mortality; it is associated with an almost doubled risk of mortality and a nearly 5-fold increase in the risk of stroke. The occurrence of AF is also usually researched in patients with advanced cancer and those undergoing active cancer treatments. During cancer treatments, the incidence rate of AF affects the prognosis of tumor treatment and challenges the treatment strategy. The present article is mainly focused on the cardiotoxicity of cancer treatments. In our review, we discuss these anticancer therapies and how they induce AF and consequently provide information on the precaution of AF during cancer treatment.
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titleAnticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms
authorYang, Xinyu ; Li, Xinye ; Yuan, Mengchen ; Tian, Chao ; Yang, Yihan ; Wang, Xiaofeng ; Zhang, Xiaoyu ; Sun, Yang ; He, Tianmai ; Han, Songjie ; Chen, Guang ; Liu, Nian ; Gao, Yonghong ; Hu, Dan ; Xing, Yanwei ; Shang, Hongcai
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