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Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and type II alcoholism.(Brief Report)(Author Abstract)

Objective: The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehyclrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism. Method: Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for... Full description

Journal Title: American Journal of Psychiatry May, 2005, Vol.162(5), p.1003(3)
Main Author: Chai, Young - Gyu
Other Authors: Oh, Dong - Yul , Chung, Eun Kee , Kim, Gil Sook , Kim, Leen , Lee, Yu - Sang , Choi, Ihn - Geun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-953X
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recordid: gale_ofa132353245
title: Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and type II alcoholism.(Brief Report)(Author Abstract)
format: Article
creator:
  • Chai, Young - Gyu
  • Oh, Dong - Yul
  • Chung, Eun Kee
  • Kim, Gil Sook
  • Kim, Leen
  • Lee, Yu - Sang
  • Choi, Ihn - Geun
subjects:
  • Alcoholism -- Research
  • Alcohol Dehydrogenases -- Research
ispartof: American Journal of Psychiatry, May, 2005, Vol.162(5), p.1003(3)
description: Objective: The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehyclrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism. Method: Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for the distribution of genotypes and alleles of ADH2, ADH3, and ALDH2. Forty-eight of the alcoholic men had type I alcoholism, and 24 had type II alcoholism. Results: The frequencies of ADH2*1 and ADH3*2 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men. The frequency of the ALDH2*1 allele was significantly higher in men with alcohol dependence than in healthy men. Conclusions: The genetic characteristics of alcohol dehydrogenases in men with type I alcoholism were similar to those of healthy men, and the genetic characteristics of aldehyde dehydrogenase in men with type I alcoholism were similar to those of men with type II alcoholism. These findings suggest that the genetic characteristics of alcohol metabolism in type I alcoholism fall between nonalcoholism and type II alcoholism.
language: English
source:
identifier: ISSN: 0002-953X
fulltext: fulltext
issn:
  • 0002-953X
  • 0002953X
url: Link


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titleAlcohol and aldehyde dehydrogenase polymorphisms in men with type I and type II alcoholism.(Brief Report)(Author Abstract)
creatorChai, Young - Gyu ; Oh, Dong - Yul ; Chung, Eun Kee ; Kim, Gil Sook ; Kim, Leen ; Lee, Yu - Sang ; Choi, Ihn - Geun
ispartofAmerican Journal of Psychiatry, May, 2005, Vol.162(5), p.1003(3)
identifierISSN: 0002-953X
subjectAlcoholism -- Research ; Alcohol Dehydrogenases -- Research
descriptionObjective: The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehyclrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism. Method: Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for the distribution of genotypes and alleles of ADH2, ADH3, and ALDH2. Forty-eight of the alcoholic men had type I alcoholism, and 24 had type II alcoholism. Results: The frequencies of ADH2*1 and ADH3*2 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men. The frequency of the ALDH2*1 allele was significantly higher in men with alcohol dependence than in healthy men. Conclusions: The genetic characteristics of alcohol dehydrogenases in men with type I alcoholism were similar to those of healthy men, and the genetic characteristics of aldehyde dehydrogenase in men with type I alcoholism were similar to those of men with type II alcoholism. These findings suggest that the genetic characteristics of alcohol metabolism in type I alcoholism fall between nonalcoholism and type II alcoholism.
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titleAlcohol and aldehyde dehydrogenase polymorphisms in men with type I and type II alcoholism.(Brief Report)(Author Abstract)
descriptionObjective: The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehyclrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism. Method: Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for the distribution of genotypes and alleles of ADH2, ADH3, and ALDH2. Forty-eight of the alcoholic men had type I alcoholism, and 24 had type II alcoholism. Results: The frequencies of ADH2*1 and ADH3*2 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men. The frequency of the ALDH2*1 allele was significantly higher in men with alcohol dependence than in healthy men. Conclusions: The genetic characteristics of alcohol dehydrogenases in men with type I alcoholism were similar to those of healthy men, and the genetic characteristics of aldehyde dehydrogenase in men with type I alcoholism were similar to those of men with type II alcoholism. These findings suggest that the genetic characteristics of alcohol metabolism in type I alcoholism fall between nonalcoholism and type II alcoholism.
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abstractObjective: The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehyclrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism. Method: Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for the distribution of genotypes and alleles of ADH2, ADH3, and ALDH2. Forty-eight of the alcoholic men had type I alcoholism, and 24 had type II alcoholism. Results: The frequencies of ADH2*1 and ADH3*2 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men. The frequency of the ALDH2*1 allele was significantly higher in men with alcohol dependence than in healthy men. Conclusions: The genetic characteristics of alcohol dehydrogenases in men with type I alcoholism were similar to those of healthy men, and the genetic characteristics of aldehyde dehydrogenase in men with type I alcoholism were similar to those of men with type II alcoholism. These findings suggest that the genetic characteristics of alcohol metabolism in type I alcoholism fall between nonalcoholism and type II alcoholism.
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