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Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis.(magnetic resonance imaging)(Author abstract)

Byline: Hong Yin (1,2,3), C. C. Tchoyoson Lim (1), Lin Ma (2), Yuangui Gao (2), Youquan Cai (2), Dejun Li (2), Yan Liang (2), Xinggao Guo (2) Keywords: amyotrophic lateral sclerosis; corticospinal tract; magnetic resonance imaging; nuclear magnetic resonance; echo planar imaging Abstract: Abstract.... Full description

Journal Title: Journal of Neurology Oct, 2004, Vol.251(7), p.1249(6)
Main Author: Yin, Hong
Other Authors: Lim, C. C. Tchoyoson , Ma, Lin , Gao, Yuangui , Cai, Youquan , Li, Dejun , Liang, Yan , Guo, Xinggao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0340-5354
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recordid: gale_ofa162882285
title: Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis.(magnetic resonance imaging)(Author abstract)
format: Article
creator:
  • Yin, Hong
  • Lim, C. C. Tchoyoson
  • Ma, Lin
  • Gao, Yuangui
  • Cai, Youquan
  • Li, Dejun
  • Liang, Yan
  • Guo, Xinggao
subjects:
  • Amyotrophic Lateral Sclerosis -- Research
  • Amyotrophic Lateral Sclerosis -- Complications And Side Effects
  • Magnetic Resonance Imaging -- Usage
  • Neurodegenerative Diseases -- Risk Factors
  • Motor Neuron Disease -- Risk Factors
ispartof: Journal of Neurology, Oct, 2004, Vol.251(7), p.1249(6)
description: Byline: Hong Yin (1,2,3), C. C. Tchoyoson Lim (1), Lin Ma (2), Yuangui Gao (2), Youquan Cai (2), Dejun Li (2), Yan Liang (2), Xinggao Guo (2) Keywords: amyotrophic lateral sclerosis; corticospinal tract; magnetic resonance imaging; nuclear magnetic resonance; echo planar imaging Abstract: Abstract. Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging (DTI) and three-dimensional magnetic resonance spectroscopic imaging (MRSI) to study the CST at different locations. Eight ALS patients were compared with normal controls. Fractional anisotropy (FA) and mean diffusivity (MD), and the ratio of N-acetyl-aspartate (NAA) to creatine (Cr) were measured at various locations in the CST, including the subcortical white matter (SWM), centrum semiovale (CS), periventricular white matter (PV), posterior limb of the internal capsule (PIC) and cerebral peduncle (CP). Patients showed significantly lower FA than controls in the CST, including the SWM, CS, PV and PIC. Although there was a trend towards elevated MD in ALS patients, this did not reach statistical significance. NAA/Cr ratios were also decreased in ALS patients compared with normal controls, with significant differences in the SWM and PV but not in PIC. Combined whole-brain DTI and MRSI can detect axonal degeneration in ALS. Measurements of FA obtained in the SWM, CS, PV and PIC, and NAA/Cr ratios in the SWM and PV yield the most robust results. Author Affiliation: (1) Dept. of Neuroradiology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433 (2) Radiology Department, Chinese PLA General Hospital, Beijing, China (3) Radiology Department, Xijing Hospital, Xi'an, China Article History: Registration Date: 01/01/2004 Received Date: 31/07/2003 Accepted Date: 06/05/2004
language: English
source:
identifier: ISSN: 0340-5354
fulltext: fulltext
issn:
  • 0340-5354
  • 03405354
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titleCombined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis.(magnetic resonance imaging)(Author abstract)
creatorYin, Hong ; Lim, C. C. Tchoyoson ; Ma, Lin ; Gao, Yuangui ; Cai, Youquan ; Li, Dejun ; Liang, Yan ; Guo, Xinggao
ispartofJournal of Neurology, Oct, 2004, Vol.251(7), p.1249(6)
identifierISSN: 0340-5354
subjectAmyotrophic Lateral Sclerosis -- Research ; Amyotrophic Lateral Sclerosis -- Complications And Side Effects ; Magnetic Resonance Imaging -- Usage ; Neurodegenerative Diseases -- Risk Factors ; Motor Neuron Disease -- Risk Factors
descriptionByline: Hong Yin (1,2,3), C. C. Tchoyoson Lim (1), Lin Ma (2), Yuangui Gao (2), Youquan Cai (2), Dejun Li (2), Yan Liang (2), Xinggao Guo (2) Keywords: amyotrophic lateral sclerosis; corticospinal tract; magnetic resonance imaging; nuclear magnetic resonance; echo planar imaging Abstract: Abstract. Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging (DTI) and three-dimensional magnetic resonance spectroscopic imaging (MRSI) to study the CST at different locations. Eight ALS patients were compared with normal controls. Fractional anisotropy (FA) and mean diffusivity (MD), and the ratio of N-acetyl-aspartate (NAA) to creatine (Cr) were measured at various locations in the CST, including the subcortical white matter (SWM), centrum semiovale (CS), periventricular white matter (PV), posterior limb of the internal capsule (PIC) and cerebral peduncle (CP). Patients showed significantly lower FA than controls in the CST, including the SWM, CS, PV and PIC. Although there was a trend towards elevated MD in ALS patients, this did not reach statistical significance. NAA/Cr ratios were also decreased in ALS patients compared with normal controls, with significant differences in the SWM and PV but not in PIC. Combined whole-brain DTI and MRSI can detect axonal degeneration in ALS. Measurements of FA obtained in the SWM, CS, PV and PIC, and NAA/Cr ratios in the SWM and PV yield the most robust results. Author Affiliation: (1) Dept. of Neuroradiology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433 (2) Radiology Department, Chinese PLA General Hospital, Beijing, China (3) Radiology Department, Xijing Hospital, Xi'an, China Article History: Registration Date: 01/01/2004 Received Date: 31/07/2003 Accepted Date: 06/05/2004
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titleCombined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis.(magnetic resonance imaging)(Author abstract)
descriptionByline: Hong Yin (1,2,3), C. C. Tchoyoson Lim (1), Lin Ma (2), Yuangui Gao (2), Youquan Cai (2), Dejun Li (2), Yan Liang (2), Xinggao Guo (2) Keywords: amyotrophic lateral sclerosis; corticospinal tract; magnetic resonance imaging; nuclear magnetic resonance; echo planar imaging Abstract: Abstract. Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging (DTI) and three-dimensional magnetic resonance spectroscopic imaging (MRSI) to study the CST at different locations. Eight ALS patients were compared with normal controls. Fractional anisotropy (FA) and mean diffusivity (MD), and the ratio of N-acetyl-aspartate (NAA) to creatine (Cr) were measured at various locations in the CST, including the subcortical white matter (SWM), centrum semiovale (CS), periventricular white matter (PV), posterior limb of the internal capsule (PIC) and cerebral peduncle (CP). Patients showed significantly lower FA than controls in the CST, including the SWM, CS, PV and PIC. Although there was a trend towards elevated MD in ALS patients, this did not reach statistical significance. NAA/Cr ratios were also decreased in ALS patients compared with normal controls, with significant differences in the SWM and PV but not in PIC. Combined whole-brain DTI and MRSI can detect axonal degeneration in ALS. Measurements of FA obtained in the SWM, CS, PV and PIC, and NAA/Cr ratios in the SWM and PV yield the most robust results. Author Affiliation: (1) Dept. of Neuroradiology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433 (2) Radiology Department, Chinese PLA General Hospital, Beijing, China (3) Radiology Department, Xijing Hospital, Xi'an, China Article History: Registration Date: 01/01/2004 Received Date: 31/07/2003 Accepted Date: 06/05/2004
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abstractByline: Hong Yin (1,2,3), C. C. Tchoyoson Lim (1), Lin Ma (2), Yuangui Gao (2), Youquan Cai (2), Dejun Li (2), Yan Liang (2), Xinggao Guo (2) Keywords: amyotrophic lateral sclerosis; corticospinal tract; magnetic resonance imaging; nuclear magnetic resonance; echo planar imaging Abstract: Abstract. Motor neuron damage and cortical spinal tract (CST) degeneration are pathological features of amyotrophic lateral sclerosis (ALS). We combined whole-brain diffusion tensor imaging (DTI) and three-dimensional magnetic resonance spectroscopic imaging (MRSI) to study the CST at different locations. Eight ALS patients were compared with normal controls. Fractional anisotropy (FA) and mean diffusivity (MD), and the ratio of N-acetyl-aspartate (NAA) to creatine (Cr) were measured at various locations in the CST, including the subcortical white matter (SWM), centrum semiovale (CS), periventricular white matter (PV), posterior limb of the internal capsule (PIC) and cerebral peduncle (CP). Patients showed significantly lower FA than controls in the CST, including the SWM, CS, PV and PIC. Although there was a trend towards elevated MD in ALS patients, this did not reach statistical significance. NAA/Cr ratios were also decreased in ALS patients compared with normal controls, with significant differences in the SWM and PV but not in PIC. Combined whole-brain DTI and MRSI can detect axonal degeneration in ALS. Measurements of FA obtained in the SWM, CS, PV and PIC, and NAA/Cr ratios in the SWM and PV yield the most robust results. Author Affiliation: (1) Dept. of Neuroradiology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433 (2) Radiology Department, Chinese PLA General Hospital, Beijing, China (3) Radiology Department, Xijing Hospital, Xi'an, China Article History: Registration Date: 01/01/2004 Received Date: 31/07/2003 Accepted Date: 06/05/2004
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