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Computational design and experimental discovery of an antiestrogenic peptide derived from [alpha]-fetoprotein.(Report)

The study presents and describes the computational design of a newly discovered antiestrogenic peptide that is derived from the [alpha]-fetoprotein compound and is commonly used as a drug to treat breast cancer in women. These analogues are found to inhibit an estrogen-dependant cell growth, also ex... Full description

Journal Title: Journal of the American Chemical Society May 16, 2007, Vol.129(19), p.6263(6)
Main Author: Kirschner, Karl N.
Other Authors: Lexa, Katrina W. , Salisburg, Amanda M. , Alser, Katherine A. , Joseph, Leroy , Andersen, Thomas T. , Bennett, James A. , Jacobson, Herbert I. , Shields, George
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-7863
Zum Text:
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recordid: gale_ofa167247805
title: Computational design and experimental discovery of an antiestrogenic peptide derived from [alpha]-fetoprotein.(Report)
format: Article
creator:
  • Kirschner, Karl N.
  • Lexa, Katrina W.
  • Salisburg, Amanda M.
  • Alser, Katherine A.
  • Joseph, Leroy
  • Andersen, Thomas T.
  • Bennett, James A.
  • Jacobson, Herbert I.
  • Shields, George
subjects:
  • Estrogen Antagonists -- Structure
  • Estrogen Antagonists -- Chemical Properties
  • Breast Cancer -- Drug Therapy
  • Breast Cancer -- Research
  • Antineoplastic Agents -- Structure
  • Antineoplastic Agents -- Chemical Properties
ispartof: Journal of the American Chemical Society, May 16, 2007, Vol.129(19), p.6263(6)
description: The study presents and describes the computational design of a newly discovered antiestrogenic peptide that is derived from the [alpha]-fetoprotein compound and is commonly used as a drug to treat breast cancer in women. These analogues are found to inhibit an estrogen-dependant cell growth, also exhibiting complete and effective biological activity, which makes it perfect and highly efficient for the treatment.
language: English
source:
identifier: ISSN: 0002-7863
fulltext: no_fulltext
issn:
  • 0002-7863
  • 00027863
url: Link


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titleComputational design and experimental discovery of an antiestrogenic peptide derived from [alpha]-fetoprotein.(Report)
creatorKirschner, Karl N. ; Lexa, Katrina W. ; Salisburg, Amanda M. ; Alser, Katherine A. ; Joseph, Leroy ; Andersen, Thomas T. ; Bennett, James A. ; Jacobson, Herbert I. ; Shields, George
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identifierISSN: 0002-7863
subjectEstrogen Antagonists -- Structure ; Estrogen Antagonists -- Chemical Properties ; Breast Cancer -- Drug Therapy ; Breast Cancer -- Research ; Antineoplastic Agents -- Structure ; Antineoplastic Agents -- Chemical Properties
descriptionThe study presents and describes the computational design of a newly discovered antiestrogenic peptide that is derived from the [alpha]-fetoprotein compound and is commonly used as a drug to treat breast cancer in women. These analogues are found to inhibit an estrogen-dependant cell growth, also exhibiting complete and effective biological activity, which makes it perfect and highly efficient for the treatment.
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titleComputational design and experimental discovery of an antiestrogenic peptide derived from [alpha]-fetoprotein.(Report)
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abstractThe study presents and describes the computational design of a newly discovered antiestrogenic peptide that is derived from the [alpha]-fetoprotein compound and is commonly used as a drug to treat breast cancer in women. These analogues are found to inhibit an estrogen-dependant cell growth, also exhibiting complete and effective biological activity, which makes it perfect and highly efficient for the treatment.
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