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An initial assessment, using 24-h [13C]leucine kinetics, of the lysine requirement of healthy adult Indian subjects

The international 1985 FAO/WHO/UNU upper dietary requirement for lysine of 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] may be inadequate for healthy Indian adults. To test this, we used a modified indicator amino acid oxidation technique to assess the adequacy of lysine intakes of 1... Full description

Journal Title: American Journal of Clinical Nutrition Jan, 1998, Vol.67(1), p.58(9)
Main Author: Kurpad, Anura V.
Other Authors: El - Khoury, Antoine E. , Beaumier, Louis , Srivatsa, Abhinash , Kuriyan, Rebecca , Raj, Tony , Borgonha, Sudhir , Ajami, Alfred M. , Young, Vernon R.
Format: Electronic Article Electronic Article
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ID: ISSN: 0002-9165
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title: An initial assessment, using 24-h [13C]leucine kinetics, of the lysine requirement of healthy adult Indian subjects
format: Article
creator:
  • Kurpad, Anura V.
  • El - Khoury, Antoine E.
  • Beaumier, Louis
  • Srivatsa, Abhinash
  • Kuriyan, Rebecca
  • Raj, Tony
  • Borgonha, Sudhir
  • Ajami, Alfred M.
  • Young, Vernon R.
subjects:
  • Leucine -- Measurement
  • Lysine -- Health Aspects
  • Nutritional Requirements
ispartof: American Journal of Clinical Nutrition, Jan, 1998, Vol.67(1), p.58(9)
description: The international 1985 FAO/WHO/UNU upper dietary requirement for lysine of 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] may be inadequate for healthy Indian adults. To test this, we used a modified indicator amino acid oxidation technique to assess the adequacy of lysine intakes of 12 and 28 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Seven healthy, male, Indian subjects were studied during each of two randomly assigned 6-d periods while receiving an otherwise adequate diet based on an L-amino acid mixture. Beginning at 1800 on day 6 of the diet, a 24-h infusion protocol in which a [[sup.13]C]leucine tracer was administered intravenously was used to assess leucine oxidation and daily leucine balance at each test lysine intake. Mean 24-h leucine oxidation was 54.7 compared with 46.9 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) and mean 24-h leucine balances were -4.1 and 3.5 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) for lysine intakes of 12 and 28 mg, respectively. Leucine balances were significantly negative (0.025 [is less than] P [is less than] 0.05) with the 12-mg lysine intake and not significantly different (P [is greater than] 0.10) from zero or equilibrium with the 28-mg intake. These findings indicate that the international requirement for lysine appears to be inadequate to maintain body amino acid homeostasis and function in apparently healthy subjects characteristic of the south Asia region. They further indicate that our previously proposed, tentative lysine requirement of 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] is probably adequate for this population. Am J Clin Nutr 1998;67:58-66.
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identifier: ISSN: 0002-9165
fulltext: fulltext
issn:
  • 0002-9165
  • 00029165
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titleAn initial assessment, using 24-h [13C]leucine kinetics, of the lysine requirement of healthy adult Indian subjects
creatorKurpad, Anura V. ; El - Khoury, Antoine E. ; Beaumier, Louis ; Srivatsa, Abhinash ; Kuriyan, Rebecca ; Raj, Tony ; Borgonha, Sudhir ; Ajami, Alfred M. ; Young, Vernon R.
ispartofAmerican Journal of Clinical Nutrition, Jan, 1998, Vol.67(1), p.58(9)
identifierISSN: 0002-9165
subjectLeucine -- Measurement ; Lysine -- Health Aspects ; Nutritional Requirements
descriptionThe international 1985 FAO/WHO/UNU upper dietary requirement for lysine of 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] may be inadequate for healthy Indian adults. To test this, we used a modified indicator amino acid oxidation technique to assess the adequacy of lysine intakes of 12 and 28 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Seven healthy, male, Indian subjects were studied during each of two randomly assigned 6-d periods while receiving an otherwise adequate diet based on an L-amino acid mixture. Beginning at 1800 on day 6 of the diet, a 24-h infusion protocol in which a [[sup.13]C]leucine tracer was administered intravenously was used to assess leucine oxidation and daily leucine balance at each test lysine intake. Mean 24-h leucine oxidation was 54.7 compared with 46.9 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) and mean 24-h leucine balances were -4.1 and 3.5 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) for lysine intakes of 12 and 28 mg, respectively. Leucine balances were significantly negative (0.025 [is less than] P [is less than] 0.05) with the 12-mg lysine intake and not significantly different (P [is greater than] 0.10) from zero or equilibrium with the 28-mg intake. These findings indicate that the international requirement for lysine appears to be inadequate to maintain body amino acid homeostasis and function in apparently healthy subjects characteristic of the south Asia region. They further indicate that our previously proposed, tentative lysine requirement of 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] is probably adequate for this population. Am J Clin Nutr 1998;67:58-66.
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titleAn initial assessment, using 24-h [13C]leucine kinetics, of the lysine requirement of healthy adult Indian subjects.
descriptionThe international 1985 FAO/WHO/UNU upper dietary requirement for lysine of 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] may be inadequate for healthy Indian adults. To test this, we used a modified indicator amino acid oxidation technique to assess the adequacy of lysine intakes of 12 and 28 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Seven healthy, male, Indian subjects were studied during each of two randomly assigned 6-d periods while receiving an otherwise adequate diet based on an L-amino acid mixture. Beginning at 1800 on day 6 of the diet, a 24-h infusion protocol in which a [[sup.13]C]leucine tracer was administered intravenously was used to assess leucine oxidation and daily leucine balance at each test lysine intake. Mean 24-h leucine oxidation was 54.7 compared with 46.9 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) and mean 24-h leucine balances were -4.1 and 3.5 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) for lysine intakes of 12 and 28 mg, respectively. Leucine balances were significantly negative (0.025 [is less than] P [is less than] 0.05) with the 12-mg lysine intake and not significantly different (P [is greater than] 0.10) from zero or equilibrium with the 28-mg intake. These findings indicate that the international requirement for lysine appears to be inadequate to maintain body amino acid homeostasis and function in apparently healthy subjects characteristic of the south Asia region. They further indicate that our previously proposed, tentative lysine requirement of 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] is probably adequate for this population. Am J Clin Nutr 1998;67:58-66.
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abstractThe international 1985 FAO/WHO/UNU upper dietary requirement for lysine of 12 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] may be inadequate for healthy Indian adults. To test this, we used a modified indicator amino acid oxidation technique to assess the adequacy of lysine intakes of 12 and 28 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1]. Seven healthy, male, Indian subjects were studied during each of two randomly assigned 6-d periods while receiving an otherwise adequate diet based on an L-amino acid mixture. Beginning at 1800 on day 6 of the diet, a 24-h infusion protocol in which a [[sup.13]C]leucine tracer was administered intravenously was used to assess leucine oxidation and daily leucine balance at each test lysine intake. Mean 24-h leucine oxidation was 54.7 compared with 46.9 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) and mean 24-h leucine balances were -4.1 and 3.5 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] (P [is less than] 0.05) for lysine intakes of 12 and 28 mg, respectively. Leucine balances were significantly negative (0.025 [is less than] P [is less than] 0.05) with the 12-mg lysine intake and not significantly different (P [is greater than] 0.10) from zero or equilibrium with the 28-mg intake. These findings indicate that the international requirement for lysine appears to be inadequate to maintain body amino acid homeostasis and function in apparently healthy subjects characteristic of the south Asia region. They further indicate that our previously proposed, tentative lysine requirement of 30 mg [multiplied by] [kg.sup.-1] [multiplied by] [d.sup.-1] is probably adequate for this population. Am J Clin Nutr 1998;67:58-66.
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