schliessen

Filtern

 

Bibliotheken

MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.(Report)

Byline: Jian Zhang (1,2), Li-Xin Qiu (1,2), Zhong-Hua Wang (1,2), Xiang-Hua Wu (1,2), Xiao-Jian Liu (1,2), Bi-Yun Wang (1,2), Xi-Chun Hu (1,2) Keywords: MTHFR; Polymorphism; Breast cancer; Susceptibility; Meta-analysis Abstract: Published data on the association between MTHFR C677T polymorphism and... Full description

Journal Title: Breast Cancer Research and Treatment Sept, 2010, Vol.123(2), p.549(7)
Main Author: Zhang, Jian
Other Authors: Qiu, Li - Xin , Wang, Zhong - Hua , Wu, Xiang - Hua , Liu, Xiao - Jian , Wang, Bi - Yun , Hu, Xi - Chun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0167-6806
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: gale_ofa234150605
title: MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.(Report)
format: Article
creator:
  • Zhang, Jian
  • Qiu, Li - Xin
  • Wang, Zhong - Hua
  • Wu, Xiang - Hua
  • Liu, Xiao - Jian
  • Wang, Bi - Yun
  • Hu, Xi - Chun
subjects:
  • Breast Cancer -- Risk Factors
  • Breast Cancer -- Genetic Aspects
  • Breast Cancer -- Analysis
  • Disease Susceptibility -- Risk Factors
  • Disease Susceptibility -- Genetic Aspects
  • Disease Susceptibility -- Analysis
  • Online Health Care Information Services -- Analysis
  • Postmenopausal Women -- Analysis
ispartof: Breast Cancer Research and Treatment, Sept, 2010, Vol.123(2), p.549(7)
description: Byline: Jian Zhang (1,2), Li-Xin Qiu (1,2), Zhong-Hua Wang (1,2), Xiang-Hua Wu (1,2), Xiao-Jian Liu (1,2), Bi-Yun Wang (1,2), Xi-Chun Hu (1,2) Keywords: MTHFR; Polymorphism; Breast cancer; Susceptibility; Meta-analysis Abstract: Published data on the association between MTHFR C677T polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between the MTHFR C677T polymorphism and breast cancer risk. The pooled ORs were performed with co-dominant model (CT vs. CC, TT vs. CC), dominant model (CT + TT vs. CC), and recessive model (TT vs. CC + CT), respectively. A total of 37 studies including 15,260 cases and 20,411 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with TT variant genotype in homozygote comparison and dominant genetic model when all studies were pooled into the meta-analysis (TT vs. CC: OR = 1.11, 95% CI = 1.01--1.23 dominant model: OR = 1.04, 95% CI = 1.00--1.09). In the subgroup analysis by ethnicity, significantly increased risks were found for TT allele carriers among Asians (TT vs. CC: OR = 1.18, 95% CI = 1.04--1.35 recessive model: OR = 1.15, 95% CI = 1.03--1.29). When stratified by study design, statistically significantly elevated risk was found in hospital-based studies (TT vs. CC: OR = 1.18, 95% CI = 1.02--1.38 recessive model: OR = 1.17, 95% CI = 1.05--1.29). In the subgroup analysis by menopausal status, statistically significantly increased risk was found among postmenopausal women (CT vs. CC: OR = 1.12, 95% CI = 1.02--1.23 dominant model: OR = 1.11, 95% CI = 1.01--1.22). In conclusion, this meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer. Author Affiliation: (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China (2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Article History: Registration Date: 31/01/2010 Received Date: 28/01/2010 Accepted Date: 30/01/2010 Online Date: 09/02/2010
language: English
source:
identifier: ISSN: 0167-6806
fulltext: fulltext
issn:
  • 0167-6806
  • 01676806
url: Link


@attributes
ID190755963
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid234150605
sourceidgale_ofa
recordidTN_gale_ofa234150605
sourceformatXML
sourcesystemPC
pqid748938133
galeid234150605
display
typearticle
titleMTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.(Report)
creatorZhang, Jian ; Qiu, Li - Xin ; Wang, Zhong - Hua ; Wu, Xiang - Hua ; Liu, Xiao - Jian ; Wang, Bi - Yun ; Hu, Xi - Chun
ispartofBreast Cancer Research and Treatment, Sept, 2010, Vol.123(2), p.549(7)
identifierISSN: 0167-6806
subjectBreast Cancer -- Risk Factors ; Breast Cancer -- Genetic Aspects ; Breast Cancer -- Analysis ; Disease Susceptibility -- Risk Factors ; Disease Susceptibility -- Genetic Aspects ; Disease Susceptibility -- Analysis ; Online Health Care Information Services -- Analysis ; Postmenopausal Women -- Analysis
descriptionByline: Jian Zhang (1,2), Li-Xin Qiu (1,2), Zhong-Hua Wang (1,2), Xiang-Hua Wu (1,2), Xiao-Jian Liu (1,2), Bi-Yun Wang (1,2), Xi-Chun Hu (1,2) Keywords: MTHFR; Polymorphism; Breast cancer; Susceptibility; Meta-analysis Abstract: Published data on the association between MTHFR C677T polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between the MTHFR C677T polymorphism and breast cancer risk. The pooled ORs were performed with co-dominant model (CT vs. CC, TT vs. CC), dominant model (CT + TT vs. CC), and recessive model (TT vs. CC + CT), respectively. A total of 37 studies including 15,260 cases and 20,411 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with TT variant genotype in homozygote comparison and dominant genetic model when all studies were pooled into the meta-analysis (TT vs. CC: OR = 1.11, 95% CI = 1.01--1.23 dominant model: OR = 1.04, 95% CI = 1.00--1.09). In the subgroup analysis by ethnicity, significantly increased risks were found for TT allele carriers among Asians (TT vs. CC: OR = 1.18, 95% CI = 1.04--1.35 recessive model: OR = 1.15, 95% CI = 1.03--1.29). When stratified by study design, statistically significantly elevated risk was found in hospital-based studies (TT vs. CC: OR = 1.18, 95% CI = 1.02--1.38 recessive model: OR = 1.17, 95% CI = 1.05--1.29). In the subgroup analysis by menopausal status, statistically significantly increased risk was found among postmenopausal women (CT vs. CC: OR = 1.12, 95% CI = 1.02--1.23 dominant model: OR = 1.11, 95% CI = 1.01--1.22). In conclusion, this meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer. Author Affiliation: (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China (2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Article History: Registration Date: 31/01/2010 Received Date: 28/01/2010 Accepted Date: 30/01/2010 Online Date: 09/02/2010
languageEnglish
source
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
scope
0gale_onefileg
1OneFile
creatorcontrib
0Zhang, Jian
1Jian Zhang
2Qiu, Li-Xin
3Wang, Zhong-Hua
4Wu, Xiang-Hua
5Liu, Xiao-Jian
6Wang, Bi-Yun
7Hu, Xi-Chun
titleMTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.(Report)
descriptionByline: Jian Zhang (1,2), Li-Xin Qiu (1,2), Zhong-Hua Wang (1,2), Xiang-Hua Wu (1,2), Xiao-Jian Liu (1,2), Bi-Yun Wang (1,2), Xi-Chun Hu (1,2) Keywords: MTHFR; Polymorphism; Breast cancer; Susceptibility; Meta-analysis Abstract: Published data on the association between MTHFR C677T polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between the MTHFR C677T polymorphism and breast cancer risk. The pooled ORs were performed with co-dominant model (CT vs. CC, TT vs. CC), dominant model (CT + TT vs. CC), and recessive model (TT vs. CC + CT), respectively. A total of 37 studies including 15,260 cases and 20,411 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with TT variant genotype in homozygote comparison and dominant genetic model when all studies were pooled into the meta-analysis (TT vs. CC: OR = 1.11, 95% CI = 1.01--1.23 dominant model: OR = 1.04, 95% CI = 1.00--1.09). In the subgroup analysis by ethnicity, significantly increased risks were found for TT allele carriers among Asians (TT vs. CC: OR = 1.18, 95% CI = 1.04--1.35 recessive model: OR = 1.15, 95% CI = 1.03--1.29). When stratified by study design, statistically significantly elevated risk was found in hospital-based studies (TT vs. CC: OR = 1.18, 95% CI = 1.02--1.38 recessive model: OR = 1.17, 95% CI = 1.05--1.29). In the subgroup analysis by menopausal status, statistically significantly increased risk was found among postmenopausal women (CT vs. CC: OR = 1.12, 95% CI = 1.02--1.23 dominant model: OR = 1.11, 95% CI = 1.01--1.22). In conclusion, this meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer. Author Affiliation: (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China (2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Article History: Registration Date: 31/01/2010 Received Date: 28/01/2010 Accepted Date: 30/01/2010 Online Date: 09/02/2010
subject
0Breast cancer--Risk factors
1Breast cancer--Genetic aspects
2Breast cancer--Analysis
3Disease susceptibility--Risk factors
4Disease susceptibility--Genetic aspects
5Disease susceptibility--Analysis
6Online health care information services--Analysis
7Postmenopausal women--Analysis
8Online health care service
general
0English
1Springer
2Cengage Learning, Inc.
sourceidgale_ofa
recordidgale_ofa234150605
issn
00167-6806
101676806
rsrctypearticle
creationdate2010
recordtypearticle
addtitleBreast Cancer Research and Treatment
searchscopeOneFile
lsr30VSR-Enriched:[galeid, doi, pages, eissn, pqid]
sort
titleMTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.(Report)
authorZhang, Jian ; Qiu, Li - Xin ; Wang, Zhong - Hua ; Wu, Xiang - Hua ; Liu, Xiao - Jian ; Wang, Bi - Yun ; Hu, Xi - Chun
creationdate20100901
facets
frbrgroupid828653266753418795
frbrtype5
languageeng
creationdate2010
topic
0Breast Cancer–Risk Factors
1Breast Cancer–Genetic Aspects
2Breast Cancer–Analysis
3Disease Susceptibility–Risk Factors
4Disease Susceptibility–Genetic Aspects
5Disease Susceptibility–Analysis
6Online Health Care Information Services–Analysis
7Postmenopausal Women–Analysis
collectionOneFile (GALE)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhang, Jian
1Qiu, Li - Xin
2Wang, Zhong - Hua
3Wu, Xiang - Hua
4Liu, Xiao - Jian
5Wang, Bi - Yun
6Hu, Xi - Chun
jtitleBreast Cancer Research and Treatment
toplevelpeer_reviewed
frbr
t2
k12010
k201676806
k4123
k52
k6549
k7breast cancer research treatment
k8mthfr c677t polymorphism associated with breast cancer susceptibility meta analysis involving 15 260 cases 20 411 controls
k9mthfrc677tpolymorphitrols
k12mthfrc677tpolymorphismass
k15jianzhang
k16zhangjian
delivery
delcategoryRemote Search Resource
fulltextfulltext
ranking
booster11
booster21
pcg_typeaggregator
addata
au
0Zhang, Jian
1Qiu, Li-Xin
2Wang, Zhong-Hua
3Wu, Xiang-Hua
4Liu, Xiao-Jian
5Wang, Bi-Yun
6Hu, Xi-Chun
atitleMTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.(Report)
jtitleBreast Cancer Research and Treatment
risdate20100901
volume123
issue2
spage549
issn0167-6806
genrearticle
ristypeJOUR
abstractByline: Jian Zhang (1,2), Li-Xin Qiu (1,2), Zhong-Hua Wang (1,2), Xiang-Hua Wu (1,2), Xiao-Jian Liu (1,2), Bi-Yun Wang (1,2), Xi-Chun Hu (1,2) Keywords: MTHFR; Polymorphism; Breast cancer; Susceptibility; Meta-analysis Abstract: Published data on the association between MTHFR C677T polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between the MTHFR C677T polymorphism and breast cancer risk. The pooled ORs were performed with co-dominant model (CT vs. CC, TT vs. CC), dominant model (CT + TT vs. CC), and recessive model (TT vs. CC + CT), respectively. A total of 37 studies including 15,260 cases and 20,411 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with TT variant genotype in homozygote comparison and dominant genetic model when all studies were pooled into the meta-analysis (TT vs. CC: OR = 1.11, 95% CI = 1.01--1.23 dominant model: OR = 1.04, 95% CI = 1.00--1.09). In the subgroup analysis by ethnicity, significantly increased risks were found for TT allele carriers among Asians (TT vs. CC: OR = 1.18, 95% CI = 1.04--1.35 recessive model: OR = 1.15, 95% CI = 1.03--1.29). When stratified by study design, statistically significantly elevated risk was found in hospital-based studies (TT vs. CC: OR = 1.18, 95% CI = 1.02--1.38 recessive model: OR = 1.17, 95% CI = 1.05--1.29). In the subgroup analysis by menopausal status, statistically significantly increased risk was found among postmenopausal women (CT vs. CC: OR = 1.12, 95% CI = 1.02--1.23 dominant model: OR = 1.11, 95% CI = 1.01--1.22). In conclusion, this meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer. Author Affiliation: (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China (2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Article History: Registration Date: 31/01/2010 Received Date: 28/01/2010 Accepted Date: 30/01/2010 Online Date: 09/02/2010
pubSpringer
lad01gale_ofa
doi10.1007/s10549-010-0783-5
pages549-555
eissn15737217
date2010-09-01