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Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Nrf2-ARE pathway

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cyto.2010.08.011 Byline: Jian Zhang, Yun Zhu, Dai Zhou, Zhong Wang, Gang Chen Keywords: rhEPO; Early brain injury; Subarachnoid hemorrhage; Nrf2 Abstract: Recombinant human erythropoietin (rhEPO) has demonstra... Full description

Journal Title: Cytokine Dec, 2010, Vol.52(3), p.252(6)
Main Author: Zhang, Jian
Other Authors: Zhu, Yun , Zhou, Dai , Wang, Zhong , Chen, Gang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1043-4666
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title: Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Nrf2-ARE pathway
format: Article
creator:
  • Zhang, Jian
  • Zhu, Yun
  • Zhou, Dai
  • Wang, Zhong
  • Chen, Gang
subjects:
  • Brain Injuries
  • Glutathione Transferase
  • Erythropoietin
  • Stroke
  • Brain Damage
  • Subarachnoid Hemorrhage
  • Quinones
  • Antioxidants (Nutrients)
  • Heme
ispartof: Cytokine, Dec, 2010, Vol.52(3), p.252(6)
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cyto.2010.08.011 Byline: Jian Zhang, Yun Zhu, Dai Zhou, Zhong Wang, Gang Chen Keywords: rhEPO; Early brain injury; Subarachnoid hemorrhage; Nrf2 Abstract: Recombinant human erythropoietin (rhEPO) has demonstrated beneficial effects against vasospasm and brain damage at the late stage of subarachnoid hemorrhage (SAH); however few investigations have been done about the effect of rhEPO on SAH-induced early brain injury (EBI) and also the underlying mechanisms remain unclear. This study was undertaken to evaluate the influence of rhEPO on the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) pathway and early brain injury in rats after SAH. Adult male SD rats were divided into four groups: (1) control group (n =18); (2) SAH group (n =18); (3) SAH+vehicle group (n =18); and (4) SAH+rhEPO group (n =18). The rat SAH model was induced by injection of 0.3ml fresh arterial, non-heparinized blood into the prechiasmatic cistern in 20s. In SAH+rhEPO group, rhEPO was administered i.p. at 1000U/kg starting 5min after the induction of SAH and repeated every 8h for 48h. Brain samples were extracted at 48h after SAH. As a result, we found that treatment with rhEPO markedly increased expressions of Nrf2-ARE pathway related agents, such as Nrf2, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase-1 (NQO1), and glutathione S-transferase [alpha]-1 (GST-[alpha]1). Administration of rhEPO following SAH significantly ameliorated EBI, such as cortical apoptosis, brain edema, and blood-brain barrier (BBB) impairment. In conclusion, post-SAH rhEPO administration may attenuate EBI in this SAH model, possibly through activating Nrf2-ARE pathway and modulating cerebral oxidative stress by inducing antioxidant and detoxifying enzymes. Author Affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, PR China Article History: Received 14 July 2010; Revised 18 August 2010; Accepted 31 August 2010
language: English
source:
identifier: ISSN: 1043-4666
fulltext: fulltext
issn:
  • 1043-4666
  • 10434666
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titleRecombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Nrf2-ARE pathway
creatorZhang, Jian ; Zhu, Yun ; Zhou, Dai ; Wang, Zhong ; Chen, Gang
ispartofCytokine, Dec, 2010, Vol.52(3), p.252(6)
identifierISSN: 1043-4666
subjectBrain Injuries ; Glutathione Transferase ; Erythropoietin ; Stroke ; Brain Damage ; Subarachnoid Hemorrhage ; Quinones ; Antioxidants (Nutrients) ; Heme
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cyto.2010.08.011 Byline: Jian Zhang, Yun Zhu, Dai Zhou, Zhong Wang, Gang Chen Keywords: rhEPO; Early brain injury; Subarachnoid hemorrhage; Nrf2 Abstract: Recombinant human erythropoietin (rhEPO) has demonstrated beneficial effects against vasospasm and brain damage at the late stage of subarachnoid hemorrhage (SAH); however few investigations have been done about the effect of rhEPO on SAH-induced early brain injury (EBI) and also the underlying mechanisms remain unclear. This study was undertaken to evaluate the influence of rhEPO on the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) pathway and early brain injury in rats after SAH. Adult male SD rats were divided into four groups: (1) control group (n =18); (2) SAH group (n =18); (3) SAH+vehicle group (n =18); and (4) SAH+rhEPO group (n =18). The rat SAH model was induced by injection of 0.3ml fresh arterial, non-heparinized blood into the prechiasmatic cistern in 20s. In SAH+rhEPO group, rhEPO was administered i.p. at 1000U/kg starting 5min after the induction of SAH and repeated every 8h for 48h. Brain samples were extracted at 48h after SAH. As a result, we found that treatment with rhEPO markedly increased expressions of Nrf2-ARE pathway related agents, such as Nrf2, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase-1 (NQO1), and glutathione S-transferase [alpha]-1 (GST-[alpha]1). Administration of rhEPO following SAH significantly ameliorated EBI, such as cortical apoptosis, brain edema, and blood-brain barrier (BBB) impairment. In conclusion, post-SAH rhEPO administration may attenuate EBI in this SAH model, possibly through activating Nrf2-ARE pathway and modulating cerebral oxidative stress by inducing antioxidant and detoxifying enzymes. Author Affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, PR China Article History: Received 14 July 2010; Revised 18 August 2010; Accepted 31 August 2010
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titleRecombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Nrf2-ARE pathway.
descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cyto.2010.08.011 Byline: Jian Zhang, Yun Zhu, Dai Zhou, Zhong Wang, Gang Chen Keywords: rhEPO; Early brain injury; Subarachnoid hemorrhage; Nrf2 Abstract: Recombinant human erythropoietin (rhEPO) has demonstrated beneficial effects against vasospasm and brain damage at the late stage of subarachnoid hemorrhage (SAH); however few investigations have been done about the effect of rhEPO on SAH-induced early brain injury (EBI) and also the underlying mechanisms remain unclear. This study was undertaken to evaluate the influence of rhEPO on the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) pathway and early brain injury in rats after SAH. Adult male SD rats were divided into four groups: (1) control group (n =18); (2) SAH group (n =18); (3) SAH+vehicle group (n =18); and (4) SAH+rhEPO group (n =18). The rat SAH model was induced by injection of 0.3ml fresh arterial, non-heparinized blood into the prechiasmatic cistern in 20s. In SAH+rhEPO group, rhEPO was administered i.p. at 1000U/kg starting 5min after the induction of SAH and repeated every 8h for 48h. Brain samples were extracted at 48h after SAH. As a result, we found that treatment with rhEPO markedly increased expressions of Nrf2-ARE pathway related agents, such as Nrf2, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase-1 (NQO1), and glutathione S-transferase [alpha]-1 (GST-[alpha]1). Administration of rhEPO following SAH significantly ameliorated EBI, such as cortical apoptosis, brain edema, and blood-brain barrier (BBB) impairment. In conclusion, post-SAH rhEPO administration may attenuate EBI in this SAH model, possibly through activating Nrf2-ARE pathway and modulating cerebral oxidative stress by inducing antioxidant and detoxifying enzymes. Author Affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, PR China Article History: Received 14 July 2010; Revised 18 August 2010; Accepted 31 August 2010
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abstractTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cyto.2010.08.011 Byline: Jian Zhang, Yun Zhu, Dai Zhou, Zhong Wang, Gang Chen Keywords: rhEPO; Early brain injury; Subarachnoid hemorrhage; Nrf2 Abstract: Recombinant human erythropoietin (rhEPO) has demonstrated beneficial effects against vasospasm and brain damage at the late stage of subarachnoid hemorrhage (SAH); however few investigations have been done about the effect of rhEPO on SAH-induced early brain injury (EBI) and also the underlying mechanisms remain unclear. This study was undertaken to evaluate the influence of rhEPO on the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) pathway and early brain injury in rats after SAH. Adult male SD rats were divided into four groups: (1) control group (n =18); (2) SAH group (n =18); (3) SAH+vehicle group (n =18); and (4) SAH+rhEPO group (n =18). The rat SAH model was induced by injection of 0.3ml fresh arterial, non-heparinized blood into the prechiasmatic cistern in 20s. In SAH+rhEPO group, rhEPO was administered i.p. at 1000U/kg starting 5min after the induction of SAH and repeated every 8h for 48h. Brain samples were extracted at 48h after SAH. As a result, we found that treatment with rhEPO markedly increased expressions of Nrf2-ARE pathway related agents, such as Nrf2, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase-1 (NQO1), and glutathione S-transferase [alpha]-1 (GST-[alpha]1). Administration of rhEPO following SAH significantly ameliorated EBI, such as cortical apoptosis, brain edema, and blood-brain barrier (BBB) impairment. In conclusion, post-SAH rhEPO administration may attenuate EBI in this SAH model, possibly through activating Nrf2-ARE pathway and modulating cerebral oxidative stress by inducing antioxidant and detoxifying enzymes. Author Affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, PR China Article History: Received 14 July 2010; Revised 18 August 2010; Accepted 31 August 2010
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