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Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.(Author abstract)(Report)

Background. In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer- lived species. The CALERIE (Comprehensive Assessment of the Long-t... Full description

Journal Title: The Journals of Gerontology Series A, Jan, 2011, Vol.66(1), p.97(12)
Main Author: Rochon, James
Other Authors: Bales, Connie W. , Ravussin, Eric , Redman, Leanne M. , Holloszy, John O. , Racette, Susan B. , Roberts, Susan B. , Das, Sai Krupa , Romashkan, Sergei , Galan, Katherine M. , Hadley, Evan C. , Kraus, William E.
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 1079-5006
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recordid: gale_ofa246011932
title: Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.(Author abstract)(Report)
format: Article
creator:
  • Rochon, James
  • Bales, Connie W.
  • Ravussin, Eric
  • Redman, Leanne M.
  • Holloszy, John O.
  • Racette, Susan B.
  • Roberts, Susan B.
  • Das, Sai Krupa
  • Romashkan, Sergei
  • Galan, Katherine M.
  • Hadley, Evan C.
  • Kraus, William E.
subjects:
  • Aging (Biology) -- Research
  • Energy Metabolism -- Research
  • Low Calorie Diet -- Research
ispartof: The Journals of Gerontology, Series A, Jan, 2011, Vol.66(1), p.97(12)
description: Background. In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer- lived species. The CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy) research program is the first systematic investigation of CR in nonobese human beings. In the phase 2 study, it is hypothesized that 2 years of sustained CR, involving a 25% reduction of ad libitum energy intake, results in beneficial effects similar to those observed in animal studies. This article presents the design and implementation of this study. Methods. The study is a multicenter, parallel-group, randomized controlled trial. A sample of 225 participants (22.0 [less than or equal to] body mass index [BMI] < 28.0 kg/[m.sup.2]) is being enrolled with 2:1 allocation to CR. Results. An intensive dietary and behavioral intervention was developed to achieve 25% CR and sustain it over the 2 years. Adherence is monitored using a doubly labeled water technique. Primary outcomes are resting metabolic rate and core temperature, and are assessed at baseline and at 6-month intervals. Secondary outcomes address oxyradical formation, cardiovascular risk markers, insulin sensitivity and secretion, immune function, neuroendocrine function, quality of life and cognitive function. Biologic materials are stored in a central repository. Conclusions. An intricate protocol has been developed to conduct this study. Procedures have been implemented to safeguard the integrity of the data and the conclusions drawn. The results will provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects. Key Words: Aging--Caloric restriction--Resting metabolic rate--Markers of inflammation--Randomized controlled trial. doi: 10.1093/gerona/glq168
language: English
source:
identifier: ISSN: 1079-5006
fulltext: fulltext
issn:
  • 1079-5006
  • 10795006
url: Link


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titleDesign and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.(Author abstract)(Report)
creatorRochon, James ; Bales, Connie W. ; Ravussin, Eric ; Redman, Leanne M. ; Holloszy, John O. ; Racette, Susan B. ; Roberts, Susan B. ; Das, Sai Krupa ; Romashkan, Sergei ; Galan, Katherine M. ; Hadley, Evan C. ; Kraus, William E.
ispartofThe Journals of Gerontology, Series A, Jan, 2011, Vol.66(1), p.97(12)
identifierISSN: 1079-5006
subjectAging (Biology) -- Research ; Energy Metabolism -- Research ; Low Calorie Diet -- Research
descriptionBackground. In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer- lived species. The CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy) research program is the first systematic investigation of CR in nonobese human beings. In the phase 2 study, it is hypothesized that 2 years of sustained CR, involving a 25% reduction of ad libitum energy intake, results in beneficial effects similar to those observed in animal studies. This article presents the design and implementation of this study. Methods. The study is a multicenter, parallel-group, randomized controlled trial. A sample of 225 participants (22.0 [less than or equal to] body mass index [BMI] < 28.0 kg/[m.sup.2]) is being enrolled with 2:1 allocation to CR. Results. An intensive dietary and behavioral intervention was developed to achieve 25% CR and sustain it over the 2 years. Adherence is monitored using a doubly labeled water technique. Primary outcomes are resting metabolic rate and core temperature, and are assessed at baseline and at 6-month intervals. Secondary outcomes address oxyradical formation, cardiovascular risk markers, insulin sensitivity and secretion, immune function, neuroendocrine function, quality of life and cognitive function. Biologic materials are stored in a central repository. Conclusions. An intricate protocol has been developed to conduct this study. Procedures have been implemented to safeguard the integrity of the data and the conclusions drawn. The results will provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects. Key Words: Aging--Caloric restriction--Resting metabolic rate--Markers of inflammation--Randomized controlled trial. doi: 10.1093/gerona/glq168
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titleDesign and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.(Author abstract)(Report)
descriptionBackground. In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer- lived species. The CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy) research program is the first systematic investigation of CR in nonobese human beings. In the phase 2 study, it is hypothesized that 2 years of sustained CR, involving a 25% reduction of ad libitum energy intake, results in beneficial effects similar to those observed in animal studies. This article presents the design and implementation of this study. Methods. The study is a multicenter, parallel-group, randomized controlled trial. A sample of 225 participants (22.0 [less than or equal to] body mass index [BMI] < 28.0 kg/[m.sup.2]) is being enrolled with 2:1 allocation to CR. Results. An intensive dietary and behavioral intervention was developed to achieve 25% CR and sustain it over the 2 years. Adherence is monitored using a doubly labeled water technique. Primary outcomes are resting metabolic rate and core temperature, and are assessed at baseline and at 6-month intervals. Secondary outcomes address oxyradical formation, cardiovascular risk markers, insulin sensitivity and secretion, immune function, neuroendocrine function, quality of life and cognitive function. Biologic materials are stored in a central repository. Conclusions. An intricate protocol has been developed to conduct this study. Procedures have been implemented to safeguard the integrity of the data and the conclusions drawn. The results will provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects. Key Words: Aging--Caloric restriction--Resting metabolic rate--Markers of inflammation--Randomized controlled trial. doi: 10.1093/gerona/glq168
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abstractBackground. In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer- lived species. The CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy) research program is the first systematic investigation of CR in nonobese human beings. In the phase 2 study, it is hypothesized that 2 years of sustained CR, involving a 25% reduction of ad libitum energy intake, results in beneficial effects similar to those observed in animal studies. This article presents the design and implementation of this study. Methods. The study is a multicenter, parallel-group, randomized controlled trial. A sample of 225 participants (22.0 [less than or equal to] body mass index [BMI] < 28.0 kg/[m.sup.2]) is being enrolled with 2:1 allocation to CR. Results. An intensive dietary and behavioral intervention was developed to achieve 25% CR and sustain it over the 2 years. Adherence is monitored using a doubly labeled water technique. Primary outcomes are resting metabolic rate and core temperature, and are assessed at baseline and at 6-month intervals. Secondary outcomes address oxyradical formation, cardiovascular risk markers, insulin sensitivity and secretion, immune function, neuroendocrine function, quality of life and cognitive function. Biologic materials are stored in a central repository. Conclusions. An intricate protocol has been developed to conduct this study. Procedures have been implemented to safeguard the integrity of the data and the conclusions drawn. The results will provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects. Key Words: Aging--Caloric restriction--Resting metabolic rate--Markers of inflammation--Randomized controlled trial. doi: 10.1093/gerona/glq168
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