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Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease.(Author abstract)(Clinical report)

Byline: Li-Qun Gu (1), Lin Zhao (1), Wei Zhu (1), Feng-Ying Li (1), Min-Jia Zhang (1), Yun Liu (1), Jian-Min Liu (1), Guang Ning (1), Yong-Ju Zhao (1) Keywords: ADMA; NT-proBNP; Hyperthyroidism; Graves' disease Abstract: Endothelial dysfunction as well as abnormal thyroid hormone levels may be respo... Full description

Journal Title: Endocrine June, 2011, Vol.39(3), p.266(6)
Main Author: Gu, Li - Qun
Other Authors: Zhao, Lin , Zhu, Wei , Li, Feng - Ying , Zhang, Min - Jia , Liu, Yun , Liu, Jian - Min , Ning, Guang , Zhao, Yong - Ju
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1355-008X
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recordid: gale_ofa255972266
title: Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease.(Author abstract)(Clinical report)
format: Article
creator:
  • Gu, Li - Qun
  • Zhao, Lin
  • Zhu, Wei
  • Li, Feng - Ying
  • Zhang, Min - Jia
  • Liu, Yun
  • Liu, Jian - Min
  • Ning, Guang
  • Zhao, Yong - Ju
subjects:
  • Natriuretic Peptides -- Health Aspects
  • Thyroid Hormones -- Health Aspects
  • Hyperthyroidism -- Physiological Aspects
  • Graves' Disease -- Care And Treatment
  • Graves' Disease -- Physiological Aspects
  • Graves' Disease -- Development And Progression
ispartof: Endocrine, June, 2011, Vol.39(3), p.266(6)
description: Byline: Li-Qun Gu (1), Lin Zhao (1), Wei Zhu (1), Feng-Ying Li (1), Min-Jia Zhang (1), Yun Liu (1), Jian-Min Liu (1), Guang Ning (1), Yong-Ju Zhao (1) Keywords: ADMA; NT-proBNP; Hyperthyroidism; Graves' disease Abstract: Endothelial dysfunction as well as abnormal thyroid hormone levels may be responsible for increased cardiovascular risk in Graves' disease (GD). Asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) are new markers of endothelial and myocardial dysfunction, respectively. The purpose of this study was to investigate the relationship among the serum levels of ADMA, NT-proBNP, and thyroid hormones in GD patients. This was a cross-sectional investigation conducted in a university teaching hospital. Two hundred and thirty-nine GD (Female: 182, Male: 57) patients and 81 normal controls were enrolled in this study. Serum levels of ADMA were positively related with FT3 (r = 0.584, P < 0.001), FT4 (r = 0.551, P < 0.001), and TRAb levels (r = 0.502, P < 0.001). Serum NT-proBNP levels were positively associated with FT3 (r = 0.243, P < 0.001) and FT4 levels (r = 0.274, P < 0.001), as well as heart rate (r = 0.271, P < 0.03). The elevation of serum ADMA and NT-proBNP levels were also observed in patients with controlled hyperthyroidism. It is thus concluded that serum ADMA and NT-proBNP levels were increased in GD patients. Future studies may determine the usefulness of these two biomarkers to detect early signs of endothelial dysfunction, vascular stiffness, and fluid volume in GD patients. Author Affiliation: (1) Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center For Endocrine and Metabolic Diseases, 197 Rui-jin Er Road, Shanghai, 200025, People's Republic of China Article History: Registration Date: 08/02/2011 Received Date: 15/01/2011 Accepted Date: 04/02/2011 Online Date: 09/03/2011 Article note: L.-Q. Gu and L. Zhao contributed equally to this work.
language: English
source:
identifier: ISSN: 1355-008X
fulltext: fulltext
issn:
  • 1355-008X
  • 1355008X
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titleRelationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease.(Author abstract)(Clinical report)
creatorGu, Li - Qun ; Zhao, Lin ; Zhu, Wei ; Li, Feng - Ying ; Zhang, Min - Jia ; Liu, Yun ; Liu, Jian - Min ; Ning, Guang ; Zhao, Yong - Ju
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identifierISSN: 1355-008X
subjectNatriuretic Peptides -- Health Aspects ; Thyroid Hormones -- Health Aspects ; Hyperthyroidism -- Physiological Aspects ; Graves' Disease -- Care And Treatment ; Graves' Disease -- Physiological Aspects ; Graves' Disease -- Development And Progression
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