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Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease.(Research)(Report)

Aim and Methods We investigated the association between polymorphisms of the angiotensin converting enzyme-1 (ACE-1) and angiotensin II type one receptor (AT1RA1166C) genes and the causation of renal disease in 76 advanced chronic kidney disease (CKD) pediatric patients undergoing maintenance hemodi... Full description

Journal Title: Journal of Inflammation August 23, 2011, Vol.8, p.20
Main Author: Elshamaa, Manal F.
Other Authors: Sabry, Samar M. , Bazaraa, Hafez M. , Koura, Hala M. , Elghoroury, Eman A. , Kantoush, Nagwa A. , Thabet, Eman H. , Abd - El Haleem, Dalia A.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Cengage Learning, Inc.
ID: ISSN: 1476-9255
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recordid: gale_ofa266288710
title: Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease.(Research)(Report)
format: Article
creator:
  • Elshamaa, Manal F.
  • Sabry, Samar M.
  • Bazaraa, Hafez M.
  • Koura, Hala M.
  • Elghoroury, Eman A.
  • Kantoush, Nagwa A.
  • Thabet, Eman H.
  • Abd - El Haleem, Dalia A.
subjects:
  • Angiotensin Converting Enzyme -- Physiological Aspects
  • Angiotensin Converting Enzyme -- Research
  • Genetic Polymorphisms -- Research
  • Kidney Diseases -- Diagnosis
  • Kidney Diseases -- Genetic Aspects
  • Kidney Diseases -- Research
  • Kidney Diseases -- Care And Treatment
ispartof: Journal of Inflammation, August 23, 2011, Vol.8, p.20
description: Aim and Methods We investigated the association between polymorphisms of the angiotensin converting enzyme-1 (ACE-1) and angiotensin II type one receptor (AT1RA1166C) genes and the causation of renal disease in 76 advanced chronic kidney disease (CKD) pediatric patients undergoing maintenance hemodialysis (MHD) or conservative treatment (CT). Serum ACE activity and creatine kinase-MB fraction (CK-MB) were measured in all groups. Left ventricular mass index (LVMI) was calculated according to echocardiographic measurements. Seventy healthy controls were also genotyped. Results The differences of D allele and DI genotype of ACE were found significant between MHD group and the controls (p = 0.0001). ACE-activity and LVMI were higher in MHD, while CK-MB was higher in CT patients than in all other groups. The combined genotype DD v/s ID+II comparison validated that DD genotype was a high risk genotype for hypertension .~89% of the DD CKD patients were found hypertensive in comparison to ~ 61% of patients of non DD genotype(p = 0.02). The MHD group showed an increased frequency of the C allele and CC genotype of the AT1RA1166C polymorphism (P = 0.0001). On multiple linear regression analysis, C-allele was independently associated with hypertension (P = 0.04). Conclusion ACE DD and AT1R A/C genotypes implicated possible roles in the hypertensive state and in renal damage among children with ESRD. This result might be useful in planning therapeutic strategies for individual patients.
language: English
source: Cengage Learning, Inc.
identifier: ISSN: 1476-9255
fulltext: fulltext
issn:
  • 1476-9255
  • 14769255
url: Link


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titleGenetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease.(Research)(Report)
creatorElshamaa, Manal F. ; Sabry, Samar M. ; Bazaraa, Hafez M. ; Koura, Hala M. ; Elghoroury, Eman A. ; Kantoush, Nagwa A. ; Thabet, Eman H. ; Abd - El Haleem, Dalia A.
ispartofJournal of Inflammation, August 23, 2011, Vol.8, p.20
identifierISSN: 1476-9255
subjectAngiotensin Converting Enzyme -- Physiological Aspects ; Angiotensin Converting Enzyme -- Research ; Genetic Polymorphisms -- Research ; Kidney Diseases -- Diagnosis ; Kidney Diseases -- Genetic Aspects ; Kidney Diseases -- Research ; Kidney Diseases -- Care And Treatment
descriptionAim and Methods We investigated the association between polymorphisms of the angiotensin converting enzyme-1 (ACE-1) and angiotensin II type one receptor (AT1RA1166C) genes and the causation of renal disease in 76 advanced chronic kidney disease (CKD) pediatric patients undergoing maintenance hemodialysis (MHD) or conservative treatment (CT). Serum ACE activity and creatine kinase-MB fraction (CK-MB) were measured in all groups. Left ventricular mass index (LVMI) was calculated according to echocardiographic measurements. Seventy healthy controls were also genotyped. Results The differences of D allele and DI genotype of ACE were found significant between MHD group and the controls (p = 0.0001). ACE-activity and LVMI were higher in MHD, while CK-MB was higher in CT patients than in all other groups. The combined genotype DD v/s ID+II comparison validated that DD genotype was a high risk genotype for hypertension .~89% of the DD CKD patients were found hypertensive in comparison to ~ 61% of patients of non DD genotype(p = 0.02). The MHD group showed an increased frequency of the C allele and CC genotype of the AT1RA1166C polymorphism (P = 0.0001). On multiple linear regression analysis, C-allele was independently associated with hypertension (P = 0.04). Conclusion ACE DD and AT1R A/C genotypes implicated possible roles in the hypertensive state and in renal damage among children with ESRD. This result might be useful in planning therapeutic strategies for individual patients.
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titleGenetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease.(Research)(Report)
descriptionAim and Methods We investigated the association between polymorphisms of the angiotensin converting enzyme-1 (ACE-1) and angiotensin II type one receptor (AT1RA1166C) genes and the causation of renal disease in 76 advanced chronic kidney disease (CKD) pediatric patients undergoing maintenance hemodialysis (MHD) or conservative treatment (CT). Serum ACE activity and creatine kinase-MB fraction (CK-MB) were measured in all groups. Left ventricular mass index (LVMI) was calculated according to echocardiographic measurements. Seventy healthy controls were also genotyped. Results The differences of D allele and DI genotype of ACE were found significant between MHD group and the controls (p = 0.0001). ACE-activity and LVMI were higher in MHD, while CK-MB was higher in CT patients than in all other groups. The combined genotype DD v/s ID+II comparison validated that DD genotype was a high risk genotype for hypertension .~89% of the DD CKD patients were found hypertensive in comparison to ~ 61% of patients of non DD genotype(p = 0.02). The MHD group showed an increased frequency of the C allele and CC genotype of the AT1RA1166C polymorphism (P = 0.0001). On multiple linear regression analysis, C-allele was independently associated with hypertension (P = 0.04). Conclusion ACE DD and AT1R A/C genotypes implicated possible roles in the hypertensive state and in renal damage among children with ESRD. This result might be useful in planning therapeutic strategies for individual patients.
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abstractAim and Methods We investigated the association between polymorphisms of the angiotensin converting enzyme-1 (ACE-1) and angiotensin II type one receptor (AT1RA1166C) genes and the causation of renal disease in 76 advanced chronic kidney disease (CKD) pediatric patients undergoing maintenance hemodialysis (MHD) or conservative treatment (CT). Serum ACE activity and creatine kinase-MB fraction (CK-MB) were measured in all groups. Left ventricular mass index (LVMI) was calculated according to echocardiographic measurements. Seventy healthy controls were also genotyped. Results The differences of D allele and DI genotype of ACE were found significant between MHD group and the controls (p = 0.0001). ACE-activity and LVMI were higher in MHD, while CK-MB was higher in CT patients than in all other groups. The combined genotype DD v/s ID+II comparison validated that DD genotype was a high risk genotype for hypertension .~89% of the DD CKD patients were found hypertensive in comparison to ~ 61% of patients of non DD genotype(p = 0.02). The MHD group showed an increased frequency of the C allele and CC genotype of the AT1RA1166C polymorphism (P = 0.0001). On multiple linear regression analysis, C-allele was independently associated with hypertension (P = 0.04). Conclusion ACE DD and AT1R A/C genotypes implicated possible roles in the hypertensive state and in renal damage among children with ESRD. This result might be useful in planning therapeutic strategies for individual patients.
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